YOR122C / PFY1

Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR122C / PFY1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:-3.42|P-value:4.22E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:-3.28|P-value:6.93E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-4.29|P-value:1.40E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-3.55|P-value:2.65E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.52|P-value:3.03E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.15|P-value:2.60E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.16|P-value:9.97E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.29|P-value:6.44E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.28|P-value:6.66E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.18|P-value:9.32E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.35|P-value:5.33E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.53|P-value:2.78E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.16|P-value:9.83E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.52|P-value:2.84E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.44|P-value:3.93E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.76|P-value:1.17E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.62|P-value:2.02E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.77|P-value:1.13E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.03|P-value:4.10E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-4.24|P-value:1.73E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.39|P-value:4.60E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.34|P-value:1.12E-5 ID:SGTC_2124|Compound:5246320|FD-Score:3.19|P-value:8.99E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.24|P-value:7.67E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.27|P-value:6.84E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.46|P-value:3.52E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.58|P-value:2.28E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.35|P-value:1.03E-5 ID:SGTC_3082|Compound:9117008|FD-Score:-3.80|P-value:1.05E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.86|P-value:8.38E-5 ID:SGTC_3090|Compound:9117696|FD-Score:-4.40|P-value:8.89E-6 ID:SGTC_3093|Compound:9117344|FD-Score:-3.93|P-value:6.40E-5 ID:SGTC_3265|Compound:9137266|FD-Score:-3.79|P-value:1.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.28|P-value:6.84E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.43|P-value:4.13E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.42|P-value:4.22E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:-3.28|P-value:6.93E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-4.29|P-value:1.40E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-3.55|P-value:2.65E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.52|P-value:3.03E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.15|P-value:2.60E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.16|P-value:9.97E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.29|P-value:6.44E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.28|P-value:6.66E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.18|P-value:9.32E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.35|P-value:5.33E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.53|P-value:2.78E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.16|P-value:9.83E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.52|P-value:2.84E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.44|P-value:3.93E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.76|P-value:1.17E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.62|P-value:2.02E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.77|P-value:1.13E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.03|P-value:4.10E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-4.24|P-value:1.73E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.39|P-value:4.60E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.34|P-value:1.12E-5 ID:SGTC_2124|Compound:5246320|FD-Score:3.19|P-value:8.99E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.24|P-value:7.67E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.27|P-value:6.84E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.46|P-value:3.52E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.58|P-value:2.28E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.35|P-value:1.03E-5 ID:SGTC_3082|Compound:9117008|FD-Score:-3.80|P-value:1.05E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.86|P-value:8.38E-5 ID:SGTC_3090|Compound:9117696|FD-Score:-4.40|P-value:8.89E-6 ID:SGTC_3093|Compound:9117344|FD-Score:-3.93|P-value:6.40E-5 ID:SGTC_3265|Compound:9137266|FD-Score:-3.79|P-value:1.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.28|P-value:6.84E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.43|P-value:4.13E-4

Top fitness defect scores for YOR122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2998 9066762 4.35 71.4 µM 1.03E-5 RPP1 & pyrimidine depletion 8 6.67E-6 0.09
2 SGTC_2114 5491910 4.34 81.2 µM 1.12E-5 3 7.26E-6 0.30
3 SGTC_1680 diphenhydramine 4.03 100.0 µM 4.10E-5 NEO1 13 2.82E-5 0.01
4 SGTC_1125 tnp00248 3.77 1.3 µM 1.12E-4 11 8.05E-5 0.01
5 SGTC_1677 st019204 3.77 53.9 µM 1.13E-4 8 8.14E-5 0.03
6 SGTC_1319 1306-0155 3.76 43.7 µM 1.17E-4 6 8.40E-5 0.18
7 SGTC_1005 4092-0690 3.65 4.4 µM 1.78E-4 plasma membrane duress 12 1.31E-4 0.04
8 SGTC_1373 2887-0003 3.62 58.5 µM 2.02E-4 Golgi 14 1.50E-4 0.05
9 SGTC_2799 7812892 3.58 81.8 µM 2.28E-4 superoxide 22 1.70E-4 0.02
10 SGTC_1879 gemcitabine 3.56 100.0 µM 2.45E-4 3 1.83E-4 0.12
11 SGTC_999 4022-0066 3.53 22.7 µM 2.78E-4 Golgi 19 2.08E-4 0.01
12 SGTC_1118 chelidonine 3.52 707.5 nM 2.84E-4 4 2.13E-4 0.14
13 SGTC_2371 9071574 3.46 200.0 µM 3.52E-4 5 2.66E-4 0.06
14 SGTC_2031 5180455 3.39 200.0 µM 4.60E-4 5 3.52E-4 0.48
15 SGTC_852 0418-0143 3.35 439.0 µM 5.33E-4 calcium & mitochondrial duress 19 4.11E-4 0.05
16 SGTC_612 0302-0167 3.29 22.4 µM 6.44E-4 copper-dependent oxidative stress 15 5.00E-4 0.26
17 SGTC_664 1222-0054 3.28 14.9 µM 6.66E-4 sphingolipid biosynthesis & PDR1 15 5.18E-4 0.10
18 SGTC_2291 7917025 3.27 104.3 µM 6.84E-4 iron homeostasis 16 5.33E-4 0.02
19 SGTC_2132 5317594 3.24 122.7 µM 7.67E-4 SWF1 & branched chain AA biosynthesis 10 6.01E-4 0.06
20 SGTC_2124 5246320 3.19 200.0 µM 8.99E-4 heme biosynthesis & mitochondrial translocase 40 7.09E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 9.98E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.095 3.55E-8 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.090 1.85E-7 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.087 3.97E-7 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.087 3.92E-7 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.082 2.07E-6 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.078 6.75E-6 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.077 7.56E-6 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.076 1.12E-5 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.073 2.46E-5 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.071 4.02E-5 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.069 6.24E-5 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.069 6.26E-5 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.069 6.52E-5 YOL090W MSH2 hom Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
0.069 6.50E-5 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication