YOR123C / LEO1

Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR123C / LEO1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.90|P-value:2.97E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.76|P-value:3.70E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.96|P-value:2.21E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.09|P-value:7.34E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.02|P-value:9.48E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.86|P-value:2.60E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:3.81|P-value:4.32E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:5.79|P-value:1.07E-9 ID:SGTC_591|Compound:4299-0174|FD-Score:3.04|P-value:8.98E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.48|P-value:1.83E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:3.63|P-value:9.12E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:5.74|P-value:1.48E-9 ID:SGTC_650|Compound:1328-0195|FD-Score:4.46|P-value:2.04E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.73|P-value:6.00E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.47|P-value:1.23E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.73|P-value:6.13E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.25|P-value:4.19E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.24|P-value:4.29E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.83|P-value:1.84E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.10|P-value:7.19E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.37|P-value:2.65E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.41|P-value:2.28E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.09|P-value:7.23E-8 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.30|P-value:3.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.42|P-value:2.12E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:6.65|P-value:2.80E-12 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.48|P-value:1.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.23|P-value:4.54E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.35|P-value:2.85E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.45|P-value:1.92E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.53|P-value:1.38E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.30|P-value:3.44E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.04|P-value:9.01E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.49|P-value:1.65E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.94|P-value:2.47E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-3.06|P-value:6.04E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.32|P-value:3.22E-4 ID:SGTC_2210|Compound:7115885|FD-Score:4.36|P-value:3.39E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.15|P-value:5.93E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.32|P-value:3.14E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.29|P-value:2.53E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.46|P-value:1.87E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.64|P-value:8.89E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.17|P-value:4.09E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.33|P-value:3.03E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.17|P-value:5.51E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.78|P-value:3.94E-7 ID:SGTC_2646|Compound:retinol|FD-Score:3.12|P-value:6.66E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.22|P-value:3.40E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.25|P-value:3.02E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.04|P-value:1.57E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.19|P-value:7.63E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.55|P-value:1.26E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.91|P-value:1.93E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-4.95|P-value:9.82E-8 ID:SGTC_3033|Compound:9090887|FD-Score:3.27|P-value:3.82E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.27|P-value:3.79E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.83|P-value:2.95E-7 ID:SGTC_3149|Compound:9097855|FD-Score:3.29|P-value:3.56E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.78|P-value:4.89E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.90|P-value:2.97E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.76|P-value:3.70E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.96|P-value:2.21E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.09|P-value:7.34E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.02|P-value:9.48E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.86|P-value:2.60E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:3.81|P-value:4.32E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:5.79|P-value:1.07E-9 ID:SGTC_591|Compound:4299-0174|FD-Score:3.04|P-value:8.98E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.48|P-value:1.83E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:3.63|P-value:9.12E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:5.74|P-value:1.48E-9 ID:SGTC_650|Compound:1328-0195|FD-Score:4.46|P-value:2.04E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.73|P-value:6.00E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.47|P-value:1.23E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.73|P-value:6.13E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.25|P-value:4.19E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.24|P-value:4.29E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.83|P-value:1.84E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:3.10|P-value:7.19E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.37|P-value:2.65E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.41|P-value:2.28E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.09|P-value:7.23E-8 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.30|P-value:3.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.42|P-value:2.12E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:6.65|P-value:2.80E-12 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.48|P-value:1.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.23|P-value:4.54E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.35|P-value:2.85E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.45|P-value:1.92E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.53|P-value:1.38E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.30|P-value:3.44E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.04|P-value:9.01E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.49|P-value:1.65E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.94|P-value:2.47E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-3.06|P-value:6.04E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.32|P-value:3.22E-4 ID:SGTC_2210|Compound:7115885|FD-Score:4.36|P-value:3.39E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.15|P-value:5.93E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.32|P-value:3.14E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.29|P-value:2.53E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.46|P-value:1.87E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.64|P-value:8.89E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.17|P-value:4.09E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.33|P-value:3.03E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.17|P-value:5.51E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.78|P-value:3.94E-7 ID:SGTC_2646|Compound:retinol|FD-Score:3.12|P-value:6.66E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.22|P-value:3.40E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.25|P-value:3.02E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.04|P-value:1.57E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.19|P-value:7.63E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.55|P-value:1.26E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.91|P-value:1.93E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-4.95|P-value:9.82E-8 ID:SGTC_3033|Compound:9090887|FD-Score:3.27|P-value:3.82E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.27|P-value:3.79E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.83|P-value:2.95E-7 ID:SGTC_3149|Compound:9097855|FD-Score:3.29|P-value:3.56E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.78|P-value:4.89E-5

Top fitness defect scores for YOR123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1303 1160-0052 6.65 261.0 µM 2.80E-12 1 1.44E-11
2 SGTC_589 1227-0070 5.79 34.1 µM 1.07E-9 12 3.59E-9
3 SGTC_648 0375-0473 5.74 33.3 µM 1.48E-9 3 4.87E-9
4 SGTC_1061 3448-9325 5.09 110.0 µM 7.23E-8 7 1.80E-7
5 SGTC_2885 9057732 4.91 52.0 µM 1.93E-7 5 4.50E-7
6 SGTC_361 000s-0510 4.86 1.4 µM 2.60E-7 17 5.94E-7
7 SGTC_3101 9120531 4.83 49.5 µM 2.95E-7 16 6.68E-7
8 SGTC_2582 agaric acid 4.78 100.0 µM 3.94E-7 redox potentiating 236 8.73E-7
9 SGTC_593 1203-0218 4.48 61.7 µM 1.83E-6 4 3.65E-6
10 SGTC_650 1328-0195 4.46 38.0 µM 2.04E-6 11 4.04E-6
11 SGTC_2210 7115885 4.36 190.4 µM 3.39E-6 cell wall signaling 25 6.49E-6
12 SGTC_2837 9008476 4.19 45.5 µM 7.63E-6 29 1.38E-5
13 SGTC_2809 7964133 4.04 13.0 µM 1.57E-5 60S ribosome export 39 2.70E-5
14 SGTC_117 lucigenin 3.96 22.1 µM 2.21E-5 redox potentiating 82 3.72E-5
15 SGTC_1983 st071813 3.94 46.9 µM 2.47E-5 RPP1 & pyrimidine depletion 20 4.13E-5
16 SGTC_17 0960-0276 3.90 49.8 µM 2.97E-5 34 4.90E-5
17 SGTC_385 1494-0393 3.81 12.4 µM 4.32E-5 29 6.96E-5
18 SGTC_3154 9100113 3.78 49.5 µM 4.89E-5 35 7.82E-5
19 SGTC_847 0342-0274 3.73 5.5 µM 6.00E-5 24 9.46E-5
20 SGTC_930 2810-3379 3.73 265.0 µM 6.13E-5 15 9.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 8.54E-17 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.132 2.03E-14 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.126 2.16E-13 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.113 5.58E-11 YER085C_p YER085C_p hom Putative protein of unknown function
0.104 1.56E-9 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.100 7.54E-9 YHR087W RTC3 hom Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
0.098 1.26E-8 YDL194W SNF3 hom Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication
0.095 3.05E-8 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.095 4.00E-8 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.095 3.94E-8 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.093 6.88E-8 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.089 2.45E-7 YML009W-B_d YML009W-B_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.089 2.56E-7 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.088 3.63E-7 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.084 1.20E-6 YIL018W RPL2B hom Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures