YOR124C / UBP2

Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR124C / UBP2

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:5.41|P-value:3.46E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.20|P-value:1.36E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.43|P-value:4.88E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.24|P-value:1.34E-7 ID:SGTC_512|Compound:prima-1|FD-Score:3.67|P-value:1.18E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.23|P-value:1.15E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:8.41|P-value:2.90E-17 ID:SGTC_896|Compound:0964-0007|FD-Score:3.63|P-value:1.42E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.16|P-value:7.61E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:7.07|P-value:9.50E-13 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.36|P-value:3.81E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.25|P-value:5.52E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.11|P-value:1.94E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.91|P-value:4.56E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.44|P-value:2.81E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.80|P-value:9.96E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:8.43|P-value:2.51E-17 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.64|P-value:1.82E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.20|P-value:6.58E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.51|P-value:2.97E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.25|P-value:5.62E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.80|P-value:8.42E-7 ID:SGTC_1712|Compound:st032288|FD-Score:-4.97|P-value:5.28E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.57|P-value:3.63E-6 ID:SGTC_1808|Compound:st050063|FD-Score:4.23|P-value:1.18E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.94|P-value:5.59E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.79|P-value:1.03E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.27|P-value:1.41E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.49|P-value:2.37E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-4.60|P-value:3.18E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.96|P-value:3.70E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.25|P-value:1.09E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.23|P-value:5.97E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.12|P-value:1.88E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.69|P-value:1.10E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.72|P-value:1.36E-4 ID:SGTC_2415|Compound:st077333|FD-Score:5.28|P-value:6.97E-8 ID:SGTC_2451|Compound:5856223|FD-Score:4.14|P-value:1.73E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.93|P-value:5.92E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.48|P-value:2.46E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.42|P-value:5.11E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.63|P-value:1.90E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.17|P-value:7.44E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.19|P-value:6.96E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.30|P-value:6.16E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.37|P-value:6.43E-6 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:3.31E-5 ID:SGTC_3310|Compound:9130229|FD-Score:3.20|P-value:6.74E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.41|P-value:3.46E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.20|P-value:1.36E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.43|P-value:4.88E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.24|P-value:1.34E-7 ID:SGTC_512|Compound:prima-1|FD-Score:3.67|P-value:1.18E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.23|P-value:1.15E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:8.41|P-value:2.90E-17 ID:SGTC_896|Compound:0964-0007|FD-Score:3.63|P-value:1.42E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.16|P-value:7.61E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:7.07|P-value:9.50E-13 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.36|P-value:3.81E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.25|P-value:5.52E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.11|P-value:1.94E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.91|P-value:4.56E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.44|P-value:2.81E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.80|P-value:9.96E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:8.43|P-value:2.51E-17 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.64|P-value:1.82E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.20|P-value:6.58E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.51|P-value:2.97E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.25|P-value:5.62E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.80|P-value:8.42E-7 ID:SGTC_1712|Compound:st032288|FD-Score:-4.97|P-value:5.28E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.57|P-value:3.63E-6 ID:SGTC_1808|Compound:st050063|FD-Score:4.23|P-value:1.18E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.94|P-value:5.59E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.79|P-value:1.03E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.27|P-value:1.41E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.49|P-value:2.37E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-4.60|P-value:3.18E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.96|P-value:3.70E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.25|P-value:1.09E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.23|P-value:5.97E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.12|P-value:1.88E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.69|P-value:1.10E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.72|P-value:1.36E-4 ID:SGTC_2415|Compound:st077333|FD-Score:5.28|P-value:6.97E-8 ID:SGTC_2451|Compound:5856223|FD-Score:4.14|P-value:1.73E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.93|P-value:5.92E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.48|P-value:2.46E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.42|P-value:5.11E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.44|P-value:2.83E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.63|P-value:1.90E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.17|P-value:7.44E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.19|P-value:6.96E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.30|P-value:6.16E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.37|P-value:6.43E-6 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:3.31E-5 ID:SGTC_3310|Compound:9130229|FD-Score:3.20|P-value:6.74E-4

Top fitness defect scores for YOR124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1564 D-Arginine 8.43 115.0 µM 2.51E-17 3 1.74E-17
2 SGTC_690 glyoxal 8.41 20.3 µM 2.90E-17 25 2.01E-17
3 SGTC_1054 3429-0080 7.07 167.0 µM 9.50E-13 2 7.68E-13
4 SGTC_103 0844-0104 5.41 51.8 µM 3.46E-8 ERAD & cell cycle 91 3.21E-8
5 SGTC_2415 st077333 5.28 57.7 µM 6.97E-8 16 6.53E-8
6 SGTC_1701 st028638 4.80 40.4 µM 8.42E-7 4 8.12E-7
7 SGTC_424 splitomicin 4.43 100.0 mM 4.88E-6 12 4.80E-6
8 SGTC_2501 sodium tetradecyl sulfate 4.42 13.4 µM 5.11E-6 23 5.03E-6
9 SGTC_3300 9124615 4.37 50.5 µM 6.43E-6 13 6.34E-6
10 SGTC_2128 5255449 4.25 168.5 µM 1.09E-5 29 1.08E-5
11 SGTC_513 4245-1575 4.23 41.7 µM 1.15E-5 unfolded protein response 101 1.14E-5
12 SGTC_1808 st050063 4.23 61.5 µM 1.18E-5 8 1.17E-5
13 SGTC_265 mycophenolic acid 4.20 32.9 µM 1.36E-5 RPP1 & pyrimidine depletion 10 1.35E-5
14 SGTC_2451 5856223 4.14 45.7 µM 1.73E-5 20 1.72E-5
15 SGTC_2166 5933061 4.12 31.5 µM 1.88E-5 tubulin folding & SWR complex 36 1.88E-5
16 SGTC_1355 1499-0035 4.11 1.7 µM 1.94E-5 14 1.94E-5
17 SGTC_1404 3909-7820 4.07 48.3 µM 2.40E-5 60S ribosome export 8 2.40E-5
18 SGTC_3307 9126885 3.99 69.3 µM 3.31E-5 33 3.32E-5
19 SGTC_2115 tiliquinol 3.96 12.8 µM 3.70E-5 9 3.71E-5
20 SGTC_1411 3909-8223 3.91 150.0 µM 4.56E-5 12 4.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 2.74E-32 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.186 1.19E-27 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.151 1.41E-18 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.131 2.68E-14 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.126 2.45E-13 YGL133W ITC1 hom Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
0.118 6.57E-12 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.116 1.53E-11 YGR089W NNF2 hom Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
0.114 4.35E-11 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.111 1.26E-10 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.110 1.89E-10 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.109 2.34E-10 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.108 3.17E-10 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.105 9.92E-10 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.104 1.50E-9 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.103 2.13E-9 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS