YOR126C / IAH1

Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR126C / IAH1

Click on Significant Values for Screen Details ID:SGTC_193|Compound:1273-0060|FD-Score:2.68|P-value:9.90E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.25|P-value:8.58E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.11|P-value:1.68E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.59|P-value:1.64E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.21|P-value:1.02E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.86|P-value:4.00E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:2.85|P-value:4.95E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.73|P-value:7.95E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-2.72|P-value:8.28E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.43|P-value:3.58E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.81|P-value:5.92E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:2.79|P-value:6.32E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.92|P-value:3.76E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.33|P-value:5.68E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.93|P-value:2.77E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.00|P-value:2.58E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.09|P-value:1.72E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.43|P-value:1.55E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:6.39|P-value:8.01E-14 ID:SGTC_1784|Compound:st039334|FD-Score:3.71|P-value:9.04E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.11|P-value:1.65E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-4.63|P-value:4.26E-8 ID:SGTC_1863|Compound:st057641|FD-Score:-3.28|P-value:7.32E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.72|P-value:8.37E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.77|P-value:6.58E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-3.26|P-value:7.97E-5 ID:SGTC_1906|Compound:st060206|FD-Score:2.92|P-value:3.81E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-2.84|P-value:5.03E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.34|P-value:2.65E-7 ID:SGTC_2033|Compound:5192550|FD-Score:-2.89|P-value:4.08E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.41|P-value:3.97E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.31|P-value:6.51E-5 ID:SGTC_2180|Compound:6301957|FD-Score:3.35|P-value:5.50E-5 ID:SGTC_2182|Compound:6325192|FD-Score:4.07|P-value:1.27E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-4.74|P-value:2.09E-8 ID:SGTC_2316|Compound:5844804|FD-Score:5.24|P-value:7.23E-10 ID:SGTC_2320|Compound:7373003|FD-Score:-3.58|P-value:1.69E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-3.67|P-value:1.11E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.82|P-value:5.01E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.94|P-value:2.56E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.60|P-value:5.05E-8 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.83|P-value:1.16E-8 ID:SGTC_2794|Compound:7785382|FD-Score:2.95|P-value:3.33E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.68|P-value:9.57E-4 ID:SGTC_2852|Compound:9023854|FD-Score:6.97|P-value:3.99E-16 ID:SGTC_2873|Compound:9040596|FD-Score:3.34|P-value:5.86E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.25|P-value:8.79E-5 ID:SGTC_2948|Compound:9070189|FD-Score:2.88|P-value:4.46E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.07|P-value:1.27E-6 ID:SGTC_3048|Compound:9093155|FD-Score:3.21|P-value:1.05E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.21|P-value:1.06E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.90|P-value:3.35E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-2.67|P-value:9.93E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.03|P-value:2.29E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.68|P-value:9.90E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.25|P-value:8.58E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.11|P-value:1.68E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.59|P-value:1.64E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.21|P-value:1.02E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.86|P-value:4.00E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:2.85|P-value:4.95E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.73|P-value:7.95E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-2.72|P-value:8.28E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.43|P-value:3.58E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.81|P-value:5.92E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:2.79|P-value:6.32E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.92|P-value:3.76E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.33|P-value:5.68E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.93|P-value:2.77E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.00|P-value:2.58E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.09|P-value:1.72E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.43|P-value:1.55E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:6.39|P-value:8.01E-14 ID:SGTC_1784|Compound:st039334|FD-Score:3.71|P-value:9.04E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.11|P-value:1.65E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-4.63|P-value:4.26E-8 ID:SGTC_1863|Compound:st057641|FD-Score:-3.28|P-value:7.32E-5 ID:SGTC_1866|Compound:st057638|FD-Score:-3.72|P-value:8.37E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.77|P-value:6.58E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-3.26|P-value:7.97E-5 ID:SGTC_1906|Compound:st060206|FD-Score:2.92|P-value:3.81E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-2.84|P-value:5.03E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.34|P-value:2.65E-7 ID:SGTC_2033|Compound:5192550|FD-Score:-2.89|P-value:4.08E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.41|P-value:3.97E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.31|P-value:6.51E-5 ID:SGTC_2180|Compound:6301957|FD-Score:3.35|P-value:5.50E-5 ID:SGTC_2182|Compound:6325192|FD-Score:4.07|P-value:1.27E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-4.74|P-value:2.09E-8 ID:SGTC_2316|Compound:5844804|FD-Score:5.24|P-value:7.23E-10 ID:SGTC_2320|Compound:7373003|FD-Score:-3.58|P-value:1.69E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-3.67|P-value:1.11E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.82|P-value:5.01E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.94|P-value:2.56E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.60|P-value:5.05E-8 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.83|P-value:1.16E-8 ID:SGTC_2794|Compound:7785382|FD-Score:2.95|P-value:3.33E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.68|P-value:9.57E-4 ID:SGTC_2852|Compound:9023854|FD-Score:6.97|P-value:3.99E-16 ID:SGTC_2873|Compound:9040596|FD-Score:3.34|P-value:5.86E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.25|P-value:8.79E-5 ID:SGTC_2948|Compound:9070189|FD-Score:2.88|P-value:4.46E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.07|P-value:1.27E-6 ID:SGTC_3048|Compound:9093155|FD-Score:3.21|P-value:1.05E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.21|P-value:1.06E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.90|P-value:3.35E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-2.67|P-value:9.93E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.03|P-value:2.29E-4

Top fitness defect scores for YOR126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2852 9023854 6.97 52.0 µM 3.99E-16 4 1.57E-12
2 SGTC_1379 2144-0755 6.39 36.5 µM 8.01E-14 4 8.50E-11
3 SGTC_2316 5844804 5.24 197.4 µM 7.23E-10 7 8.14E-8
4 SGTC_1376 2910-0861 4.43 41.3 µM 1.55E-7 12 4.71E-6
5 SGTC_2014 4013930 4.34 200.0 µM 2.65E-7 20 7.06E-6
6 SGTC_2182 6325192 4.07 200.0 µM 1.27E-6 Golgi 13 2.31E-5
7 SGTC_1277 0873-0036 3.93 22.0 µM 2.77E-6 PDR1 22 4.18E-5
8 SGTC_3080 9117754 3.90 49.5 µM 3.35E-6 18 4.83E-5
9 SGTC_1784 st039334 3.71 36.3 µM 9.04E-6 24 1.03E-4
10 SGTC_2180 6301957 3.35 200.0 µM 5.50E-5 RSC complex & mRNA processing 16 4.05E-4
11 SGTC_2873 9040596 3.34 71.4 µM 5.86E-5 74 4.25E-4
12 SGTC_288 1315-0019 3.25 35.1 µM 8.58E-5 RSC & ERG11 47 5.69E-4
13 SGTC_2930 9013230 3.25 14.9 µM 8.79E-5 heme biosynthesis & mitochondrial translocase 72 5.79E-4
14 SGTC_3048 9093155 3.21 49.5 µM 1.05E-4 18 6.62E-4
15 SGTC_3073 9114972 3.21 49.5 µM 1.06E-4 60S ribosome export 31 6.70E-4
16 SGTC_1834 st055981 3.11 52.8 µM 1.65E-4 RPP1 & pyrimidine depletion 67 9.36E-4
17 SGTC_310 1273-0058 3.11 1.1 µM 1.68E-4 mitochondrial stress 334 9.49E-4
18 SGTC_2794 7785382 2.95 27.3 µM 3.33E-4 101 0.00160
19 SGTC_1142 3253-1408 2.92 9.8 µM 3.76E-4 44 0.00176
20 SGTC_1906 st060206 2.92 94.7 µM 3.81E-4 73 0.00178

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.30E-18 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.120 2.72E-12 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.120 3.62E-12 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.111 1.29E-10 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
0.107 5.78E-10 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.099 7.95E-9 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.098 1.21E-8 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.097 2.06E-8 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.096 2.37E-8 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.093 6.24E-8 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.093 7.09E-8 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.092 9.94E-8 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092 1.01E-7 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.092 1.00E-7 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.091 1.42E-7 YLR352W_p YLR352W_p hom Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene