YOR129C / AFI1

Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR129C / AFI1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.37|P-value:1.59E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.01|P-value:6.69E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.52|P-value:8.76E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:4.82|P-value:1.33E-7 ID:SGTC_727|Compound:3032-0951|FD-Score:3.04|P-value:5.98E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.17|P-value:3.61E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.36|P-value:1.63E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.32|P-value:1.96E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.11|P-value:4.63E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.53|P-value:8.29E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.31|P-value:2.08E-4 ID:SGTC_1700|Compound:st030840|FD-Score:4.69|P-value:2.75E-7 ID:SGTC_1702|Compound:st027038|FD-Score:3.67|P-value:4.46E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.48|P-value:1.03E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.69|P-value:4.13E-5 ID:SGTC_2171|Compound:5739187|FD-Score:2.97|P-value:7.68E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.11|P-value:4.49E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.11|P-value:4.39E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.16|P-value:3.69E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.21|P-value:3.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.08|P-value:5.13E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.84|P-value:2.12E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.65|P-value:5.02E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.46|P-value:1.10E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-4.76|P-value:1.82E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.15|P-value:3.85E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.35|P-value:1.74E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.16|P-value:3.70E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.64|P-value:5.21E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.02|P-value:6.45E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.92|P-value:1.42E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.20|P-value:3.18E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.30|P-value:2.25E-6 ID:SGTC_3124|Compound:9127567|FD-Score:-4.48|P-value:8.30E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.78|P-value:2.74E-5 ID:SGTC_3127|Compound:9126946|FD-Score:4.34|P-value:1.86E-6 ID:SGTC_3132|Compound:9126706|FD-Score:3.26|P-value:2.52E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.06|P-value:5.52E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.99|P-value:7.04E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.13|P-value:4.29E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.37|P-value:1.59E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.01|P-value:6.69E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.52|P-value:8.76E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:4.82|P-value:1.33E-7 ID:SGTC_727|Compound:3032-0951|FD-Score:3.04|P-value:5.98E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.17|P-value:3.61E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.36|P-value:1.63E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.32|P-value:1.96E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.11|P-value:4.63E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.53|P-value:8.29E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.31|P-value:2.08E-4 ID:SGTC_1700|Compound:st030840|FD-Score:4.69|P-value:2.75E-7 ID:SGTC_1702|Compound:st027038|FD-Score:3.67|P-value:4.46E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.48|P-value:1.03E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.69|P-value:4.13E-5 ID:SGTC_2171|Compound:5739187|FD-Score:2.97|P-value:7.68E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.11|P-value:4.49E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.11|P-value:4.39E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.16|P-value:3.69E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.21|P-value:3.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.08|P-value:5.13E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.84|P-value:2.12E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.65|P-value:5.02E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.46|P-value:1.10E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-4.76|P-value:1.82E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.15|P-value:3.85E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.35|P-value:1.74E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.16|P-value:3.70E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.64|P-value:5.21E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.02|P-value:6.45E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.92|P-value:1.42E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.20|P-value:3.18E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.30|P-value:2.25E-6 ID:SGTC_3124|Compound:9127567|FD-Score:-4.48|P-value:8.30E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.78|P-value:2.74E-5 ID:SGTC_3127|Compound:9126946|FD-Score:4.34|P-value:1.86E-6 ID:SGTC_3132|Compound:9126706|FD-Score:3.26|P-value:2.52E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.06|P-value:5.52E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.99|P-value:7.04E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.13|P-value:4.29E-4

Top fitness defect scores for YOR129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_372 0155-0182 4.82 15.9 µM 1.33E-7 mitochondrial response to ROS 17 7.09E-7
2 SGTC_1700 st030840 4.69 7.9 µM 2.75E-7 PDR1 14 1.35E-6
3 SGTC_3127 9126946 4.34 49.5 µM 1.86E-6 ERG2 11 7.25E-6
4 SGTC_3093 9117344 4.30 49.5 µM 2.25E-6 60S ribosome export 10 8.58E-6
5 SGTC_2983 9022671 3.92 13.0 µM 1.42E-5 60S ribosome export 10 4.36E-5
6 SGTC_2598 perillyl alcohol 3.84 100.0 µM 2.12E-5 36 6.21E-5
7 SGTC_3126 9127922 3.78 49.5 µM 2.74E-5 fatty acid desaturase (OLE1) 37 7.81E-5
8 SGTC_2061 5245884 3.69 81.0 µM 4.13E-5 tubulin folding & SWR complex 29 1.12E-4
9 SGTC_1702 st027038 3.67 51.0 µM 4.46E-5 19 1.20E-4
10 SGTC_2601 securinine 3.65 100.0 µM 5.02E-5 39 1.33E-4
11 SGTC_2862 9027634 3.64 71.4 µM 5.21E-5 ERG2 38 1.38E-4
12 SGTC_1619 st003326 3.53 88.7 µM 8.29E-5 60S ribosome export 28 2.08E-4
13 SGTC_369 0957-0393 3.52 4.5 µM 8.76E-5 cell wall signaling 39 2.18E-4
14 SGTC_2003 4023581 3.48 200.0 µM 1.03E-4 cell wall signaling 48 2.51E-4
15 SGTC_19 0279-0214 3.37 38.4 µM 1.59E-4 TRP & mitochondrial translation 67 3.70E-4
16 SGTC_2744 captopril 3.35 92.0 µM 1.74E-4 60S ribosome export 23 4.00E-4
17 SGTC_979 1426-2828 3.32 121.0 µM 1.96E-4 41 4.44E-4
18 SGTC_785 1270-0111 3.31 65.3 µM 2.07E-4 54 4.67E-4
19 SGTC_1685 st024049 3.31 53.1 µM 2.08E-4 TSC3-RPN4 32 4.68E-4
20 SGTC_3132 9126706 3.26 49.5 µM 2.52E-4 53 5.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.74E-10 YNL254C RTC4 hom Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.100 6.65E-9 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.094 4.95E-8 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.093 6.89E-8 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.083 1.49E-6 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.078 6.91E-6 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.076 9.29E-6 YDR292C SRP101 het Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
0.076 9.50E-6 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.075 1.21E-5 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.073 2.56E-5 YAL022C FUN26 hom Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
0.071 4.08E-5 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.070 4.99E-5 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.068 7.19E-5 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.068 8.62E-5 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.068 8.68E-5 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain