Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
Profile for YOR131C / YOR131C

Click on Significant Values for Screen Details

Top fitness defect scores for YOR131C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_2014 4013930 11.00 200.0 µM 2.26E-25 1 2.28E-28
2 SGTC_152 4469-0003 7.44 551.2 µM 1.24E-12 4 5.04E-14
3 SGTC_1258 0671-0043 5.64 57.1 µM 5.43E-8 3 8.38E-9
4 SGTC_2834 9001755 4.92 58.4 µM 1.84E-6 18 4.38E-7
5 SGTC_622 1348-1566 4.87 26.3 µM 2.33E-6 10 5.71E-7
6 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.63 100.0 µM 6.46E-6 19 1.79E-6
7 SGTC_2273 7815444 4.48 169.1 µM 1.26E-5 13 3.80E-6
8 SGTC_1559 coumarin 343 4.41 70.1 µM 1.64E-5 6 5.11E-6
9 SGTC_2286 7945697 4.40 125.0 µM 1.70E-5 40 5.33E-6
10 SGTC_3043 9092303 4.38 49.5 µM 1.85E-5 9 5.86E-6
11 SGTC_645 0845-0943 4.33 5.4 µM 2.31E-5 60S ribosome export 5 7.48E-6
12 SGTC_636 0kpi-0074 4.20 126.0 µM 3.84E-5 16 1.33E-5
13 SGTC_1522 st012842 4.16 45.6 µM 4.52E-5 RNA pol III & RNase P/MRP 20 1.59E-5
14 SGTC_1496 4469-0713 4.03 57.4 µM 7.40E-5 17 2.77E-5
15 SGTC_3139 9095020 3.88 49.5 µM 1.30E-4 9 5.20E-5
16 SGTC_459 nigericin 3.83 15.3 µM 1.58E-4 66 6.50E-5
17 SGTC_1787 fluconazole 3.78 80.0 µM 1.85E-4 iron homeostasis 29 7.74E-5
18 SGTC_3147 9097027 3.74 49.5 µM 2.17E-4 31 9.22E-5
19 SGTC_2970 9090938 3.66 41.9 µM 2.82E-4 RNA processing & uracil transport 53 1.24E-4
20 SGTC_2271 7849410 3.63 118.6 µM 3.17E-4 16 1.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.18E-13 YJR005C-A_p YJR005C-A_p hom Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
0.116 1.36E-11 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.108 4.12E-10 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.102 2.66E-9 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.099 8.25E-9 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.099 8.43E-9 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.097 1.54E-8 YML003W_p YML003W_p hom Putative protein of unknown function
0.095 3.35E-8 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.094 4.71E-8 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.088 3.24E-7 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
0.088 3.40E-7 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.084 1.03E-6 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.083 1.31E-6 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.083 1.44E-6 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.083 1.57E-6 YPL201C YIG1 hom Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol