YOR134W / BAG7

Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR134W / BAG7

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.59|P-value:3.58E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.35|P-value:7.78E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.86|P-value:2.54E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.73|P-value:2.25E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.43|P-value:6.14E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.63|P-value:3.11E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.51|P-value:4.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.99|P-value:1.43E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.37|P-value:7.39E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.98|P-value:1.36E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.41|P-value:9.33E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.85|P-value:1.45E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.48|P-value:5.11E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-4.54|P-value:1.56E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.54|P-value:9.87E-6 ID:SGTC_1008|Compound:4106-0037|FD-Score:-4.51|P-value:1.79E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.03|P-value:7.43E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.72|P-value:7.47E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.72|P-value:2.29E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.95|P-value:1.01E-4 ID:SGTC_1611|Compound:st001856|FD-Score:5.26|P-value:4.17E-7 ID:SGTC_1629|Compound:st005085|FD-Score:3.73|P-value:2.19E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.62|P-value:3.20E-4 ID:SGTC_1901|Compound:st060216|FD-Score:6.24|P-value:2.65E-9 ID:SGTC_2071|Compound:5230951|FD-Score:3.75|P-value:2.05E-4 ID:SGTC_2101|Compound:5377231|FD-Score:5.03|P-value:1.18E-6 ID:SGTC_2210|Compound:7115885|FD-Score:4.00|P-value:8.35E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.62|P-value:3.22E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.85|P-value:2.62E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:3.82|P-value:1.60E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.78|P-value:1.86E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.37|P-value:7.51E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.51|P-value:6.69E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.57|P-value:5.57E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.36|P-value:7.77E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-8.21|P-value:1.96E-14 ID:SGTC_3122|Compound:9126309|FD-Score:3.37|P-value:7.49E-4 ID:SGTC_3225|Compound:9130819|FD-Score:-4.40|P-value:2.75E-5 ID:SGTC_3254|Compound:9136651|FD-Score:3.74|P-value:2.11E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.18|P-value:4.24E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.59|P-value:3.58E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.35|P-value:7.78E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.86|P-value:2.54E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.73|P-value:2.25E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.43|P-value:6.14E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.63|P-value:3.11E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.51|P-value:4.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.99|P-value:1.43E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.37|P-value:7.39E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.98|P-value:1.36E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.41|P-value:9.33E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.85|P-value:1.45E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.48|P-value:5.11E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-4.54|P-value:1.56E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.54|P-value:9.87E-6 ID:SGTC_1008|Compound:4106-0037|FD-Score:-4.51|P-value:1.79E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.03|P-value:7.43E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-4.72|P-value:7.47E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.72|P-value:2.29E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.95|P-value:1.01E-4 ID:SGTC_1611|Compound:st001856|FD-Score:5.26|P-value:4.17E-7 ID:SGTC_1629|Compound:st005085|FD-Score:3.73|P-value:2.19E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.62|P-value:3.20E-4 ID:SGTC_1901|Compound:st060216|FD-Score:6.24|P-value:2.65E-9 ID:SGTC_2071|Compound:5230951|FD-Score:3.75|P-value:2.05E-4 ID:SGTC_2101|Compound:5377231|FD-Score:5.03|P-value:1.18E-6 ID:SGTC_2210|Compound:7115885|FD-Score:4.00|P-value:8.35E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.62|P-value:3.22E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.85|P-value:2.62E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:3.82|P-value:1.60E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.78|P-value:1.86E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.37|P-value:7.51E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.51|P-value:6.69E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.57|P-value:5.57E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.36|P-value:7.77E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-8.21|P-value:1.96E-14 ID:SGTC_3122|Compound:9126309|FD-Score:3.37|P-value:7.49E-4 ID:SGTC_3225|Compound:9130819|FD-Score:-4.40|P-value:2.75E-5 ID:SGTC_3254|Compound:9136651|FD-Score:3.74|P-value:2.11E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.18|P-value:4.24E-5

Top fitness defect scores for YOR134W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1901 st060216 6.24 58.6 µM 2.65E-9 4 2.24E-10
2 SGTC_1611 st001856 5.26 99.4 µM 4.17E-7 6 7.40E-8
3 SGTC_2101 5377231 5.03 179.2 µM 1.18E-6 3 2.44E-7
4 SGTC_475 α-linolenic acid 4.99 10.0 µM 1.43E-6 excess fatty acid 7 3.02E-7
5 SGTC_367 0335-0881 4.86 7.1 µM 2.54E-6 ubiquinone biosynthesis & proteasome 45 5.84E-7
6 SGTC_2459 5811157 4.85 9.2 µM 2.62E-6 mitochondrial processes 3 6.06E-7
7 SGTC_944 3370-0224 4.54 231.0 µM 9.87E-6 14 2.75E-6
8 SGTC_520 3584-0023 4.46 682.0 µM 1.40E-5 15 4.09E-6
9 SGTC_3295 9122362 4.18 53.6 µM 4.24E-5 10 1.45E-5
10 SGTC_1020 4335-0961 4.03 93.3 µM 7.43E-5 15 2.75E-5
11 SGTC_2210 7115885 4.00 190.4 µM 8.35E-5 cell wall signaling 31 3.14E-5
12 SGTC_1364 1653-0028 3.95 37.6 µM 1.01E-4 22 3.92E-5
13 SGTC_915 methyl methanesulfonate (MMS) 3.85 110.0 mM 1.45E-4 DNA damage response 48 5.89E-5
14 SGTC_2508 celastrol 3.82 40.5 µM 1.60E-4 PDR1 20 6.60E-5
15 SGTC_2570 licareol 3.79 100.0 µM 1.78E-4 36 7.42E-5
16 SGTC_2556 citropten 3.78 84.6 µM 1.86E-4 27 7.84E-5
17 SGTC_2071 5230951 3.75 39.9 µM 2.05E-4 TSC3-RPN4 23 8.72E-5
18 SGTC_3254 9136651 3.74 49.5 µM 2.11E-4 DNA damage response 27 9.02E-5
19 SGTC_1629 st005085 3.73 44.9 µM 2.19E-4 RPP1 & pyrimidine depletion 43 9.42E-5
20 SGTC_403 arphamenine a 3.73 50.0 µM 2.25E-4 60S ribosome export 20 9.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.32E-7 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.088 3.26E-7 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.084 9.89E-7 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.082 2.10E-6 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.081 2.79E-6 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.076 1.02E-5 YIL015W BAR1 hom Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
0.075 1.22E-5 YNL087W TCB2 hom ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
0.074 1.77E-5 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.074 1.92E-5 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.072 2.92E-5 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.071 3.92E-5 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.070 4.98E-5 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.069 6.86E-5 YDL231C BRE4 hom Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
0.069 7.12E-5 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.067 1.04E-4 YDR363W ESC2 hom Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member