YOR135C_d / IRC14

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR135C / IRC14

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:5.24|P-value:1.22E-8 ID:SGTC_95|Compound:0471-0001|FD-Score:4.62|P-value:4.32E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:3.26|P-value:2.50E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:2.90|P-value:9.82E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.45|P-value:1.15E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.65|P-value:3.63E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:-5.30|P-value:1.34E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:4.25|P-value:2.93E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:3.01|P-value:6.54E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.62|P-value:5.74E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.34|P-value:1.78E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.20|P-value:1.64E-8 ID:SGTC_622|Compound:1348-1566|FD-Score:5.10|P-value:2.87E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:3.28|P-value:2.29E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.56|P-value:7.29E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.12|P-value:4.23E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.30|P-value:2.81E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.52|P-value:8.80E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:2.91|P-value:9.38E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.12|P-value:5.47E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.43|P-value:1.18E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.42|P-value:1.30E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.86|P-value:1.92E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.21|P-value:3.05E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.34|P-value:1.80E-4 ID:SGTC_1548|Compound:st061468|FD-Score:4.44|P-value:1.13E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.64|P-value:5.15E-5 ID:SGTC_1722|Compound:st034304|FD-Score:4.06|P-value:7.60E-6 ID:SGTC_1820|Compound:st053765|FD-Score:3.26|P-value:2.47E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-2.97|P-value:9.52E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.86|P-value:2.66E-5 ID:SGTC_2063|Compound:5246145|FD-Score:2.95|P-value:8.09E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.07|P-value:5.22E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.14|P-value:3.93E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.82|P-value:2.35E-5 ID:SGTC_2180|Compound:6301957|FD-Score:3.93|P-value:1.41E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:2.91|P-value:9.32E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-5.06|P-value:5.40E-8 ID:SGTC_2285|Compound:7945142|FD-Score:5.09|P-value:3.13E-8 ID:SGTC_2286|Compound:7945697|FD-Score:-3.32|P-value:2.53E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.70|P-value:5.29E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.24|P-value:3.09E-6 ID:SGTC_2348|Compound:9022543|FD-Score:5.10|P-value:2.95E-8 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.73|P-value:2.46E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-4.17|P-value:6.23E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.23|P-value:2.76E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.66|P-value:4.67E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.69|P-value:4.12E-5 ID:SGTC_3044|Compound:9093193|FD-Score:2.92|P-value:9.14E-4 ID:SGTC_3057|Compound:9095946|FD-Score:4.19|P-value:4.07E-6 ID:SGTC_3058|Compound:9093861|FD-Score:2.90|P-value:9.54E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.24|P-value:2.72E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-4.48|P-value:1.32E-6 ID:SGTC_3224|Compound:9130643|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.60|P-value:6.15E-5 ID:SGTC_3277|Compound:9138724|FD-Score:3.52|P-value:8.69E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.27|P-value:3.18E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.24|P-value:1.22E-8 ID:SGTC_95|Compound:0471-0001|FD-Score:4.62|P-value:4.32E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:3.26|P-value:2.50E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:2.90|P-value:9.82E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.45|P-value:1.15E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.65|P-value:3.63E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:-5.30|P-value:1.34E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:4.25|P-value:2.93E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:3.01|P-value:6.54E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.62|P-value:5.74E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.34|P-value:1.78E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.20|P-value:1.64E-8 ID:SGTC_622|Compound:1348-1566|FD-Score:5.10|P-value:2.87E-8 ID:SGTC_631|Compound:k072-0230|FD-Score:3.28|P-value:2.29E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.56|P-value:7.29E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.12|P-value:4.23E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.30|P-value:2.81E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.52|P-value:8.80E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:2.91|P-value:9.38E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.12|P-value:5.47E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.43|P-value:1.18E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.42|P-value:1.30E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.86|P-value:1.92E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.21|P-value:3.05E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.34|P-value:1.80E-4 ID:SGTC_1548|Compound:st061468|FD-Score:4.44|P-value:1.13E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.64|P-value:5.15E-5 ID:SGTC_1722|Compound:st034304|FD-Score:4.06|P-value:7.60E-6 ID:SGTC_1820|Compound:st053765|FD-Score:3.26|P-value:2.47E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-2.97|P-value:9.52E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.86|P-value:2.66E-5 ID:SGTC_2063|Compound:5246145|FD-Score:2.95|P-value:8.09E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.07|P-value:5.22E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.14|P-value:3.93E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.82|P-value:2.35E-5 ID:SGTC_2180|Compound:6301957|FD-Score:3.93|P-value:1.41E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:2.91|P-value:9.32E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-5.06|P-value:5.40E-8 ID:SGTC_2285|Compound:7945142|FD-Score:5.09|P-value:3.13E-8 ID:SGTC_2286|Compound:7945697|FD-Score:-3.32|P-value:2.53E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.70|P-value:5.29E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.24|P-value:3.09E-6 ID:SGTC_2348|Compound:9022543|FD-Score:5.10|P-value:2.95E-8 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.73|P-value:2.46E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-4.17|P-value:6.23E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.23|P-value:2.76E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.66|P-value:4.67E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.69|P-value:4.12E-5 ID:SGTC_3044|Compound:9093193|FD-Score:2.92|P-value:9.14E-4 ID:SGTC_3057|Compound:9095946|FD-Score:4.19|P-value:4.07E-6 ID:SGTC_3058|Compound:9093861|FD-Score:2.90|P-value:9.54E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.24|P-value:2.72E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-4.48|P-value:1.32E-6 ID:SGTC_3224|Compound:9130643|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.60|P-value:6.15E-5 ID:SGTC_3277|Compound:9138724|FD-Score:3.52|P-value:8.69E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.27|P-value:3.18E-4

Top fitness defect scores for YOR135C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 5.24 272.1 µM 1.22E-8 ubiquinone biosynthesis & proteasome 101 7.88E-8
2 SGTC_621 3584-0052 5.20 32.1 µM 1.64E-8 10 1.02E-7
3 SGTC_622 1348-1566 5.10 26.3 µM 2.87E-8 5 1.69E-7
4 SGTC_2348 9022543 5.10 33.4 µM 2.95E-8 mitochondrial processes 12 1.73E-7
5 SGTC_2285 7945142 5.09 200.0 µM 3.13E-8 5 1.82E-7
6 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.73 200.0 µM 2.46E-7 7 1.15E-6
7 SGTC_396 dithiazanine 4.65 1.2 µM 3.63E-7 3 1.63E-6
8 SGTC_95 0471-0001 4.62 561.1 µM 4.32E-7 13 1.90E-6
9 SGTC_1548 st061468 4.44 90.8 µM 1.13E-6 5 4.48E-6
10 SGTC_1190 1486-1332 4.43 13.0 µM 1.18E-6 9 4.66E-6
11 SGTC_431 k089-0097 4.25 107.0 µM 2.93E-6 iron homeostasis 29 1.05E-5
12 SGTC_2340 7987427 4.24 183.4 µM 3.09E-6 25 1.10E-5
13 SGTC_3057 9095946 4.19 49.5 µM 4.07E-6 Golgi 9 1.41E-5
14 SGTC_1722 st034304 4.06 3.6 µM 7.60E-6 mitochondrial processes 22 2.46E-5
15 SGTC_1134 3477-0009 3.97 42.5 µM 1.18E-5 45 3.66E-5
16 SGTC_2180 6301957 3.93 200.0 µM 1.41E-5 RSC complex & mRNA processing 8 4.27E-5
17 SGTC_1382 3002-2117 3.86 298.0 µM 1.92E-5 12 5.64E-5
18 SGTC_2151 5563267 3.82 85.4 µM 2.35E-5 24 6.76E-5
19 SGTC_2995 9067767 3.69 71.4 µM 4.12E-5 26 1.11E-4
20 SGTC_2873 9040596 3.66 71.4 µM 4.67E-5 58 1.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.62E-17 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.116 1.53E-11 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.116 1.83E-11 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.096 2.66E-8 YLR103C CDC45 het DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
0.096 2.85E-8 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.090 2.02E-7 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.086 5.20E-7 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.086 6.81E-7 YBR065C ECM2 hom Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
0.085 8.43E-7 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.085 8.89E-7 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.083 1.29E-6 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.083 1.40E-6 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.082 1.95E-6 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.081 2.38E-6 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.55E-6 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly