YOR137C / SIA1

Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR137C / SIA1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:4.00|P-value:1.51E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.22|P-value:4.61E-8 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.13|P-value:7.46E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.45|P-value:1.56E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.82|P-value:3.35E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.78|P-value:5.89E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.56|P-value:9.95E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.27|P-value:3.07E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.51|P-value:1.28E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.26|P-value:3.17E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.72|P-value:5.07E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.37|P-value:2.08E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.66|P-value:6.51E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.84|P-value:3.02E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.23|P-value:3.63E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.12|P-value:7.74E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:7.19|P-value:4.13E-14 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.65|P-value:1.00E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.62|P-value:1.15E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-4.46|P-value:2.66E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.85|P-value:2.15E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.36|P-value:3.21E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.25|P-value:3.37E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.12|P-value:5.36E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.20|P-value:4.09E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.04|P-value:1.93E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.31|P-value:2.67E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.37|P-value:2.13E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.58|P-value:9.30E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.29|P-value:2.90E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.39|P-value:1.98E-4 ID:SGTC_2445|Compound:5742597|FD-Score:2.98|P-value:8.94E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.26|P-value:3.26E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.29|P-value:4.12E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.51|P-value:1.23E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.09|P-value:8.58E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.07|P-value:8.95E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.97|P-value:9.21E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.98|P-value:8.83E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.01|P-value:7.92E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.21|P-value:8.80E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.55|P-value:1.07E-6 ID:SGTC_2993|Compound:9054257|FD-Score:4.62|P-value:7.50E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.55|P-value:1.05E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.14|P-value:5.09E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.00|P-value:1.51E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.22|P-value:4.61E-8 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.13|P-value:7.46E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.45|P-value:1.56E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.82|P-value:3.35E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.78|P-value:5.89E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.56|P-value:9.95E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.27|P-value:3.07E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.51|P-value:1.28E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.40|P-value:1.86E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.26|P-value:3.17E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.72|P-value:5.07E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.37|P-value:2.08E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.66|P-value:6.51E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.84|P-value:3.02E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.23|P-value:3.63E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.12|P-value:7.74E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:7.19|P-value:4.13E-14 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.65|P-value:1.00E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.62|P-value:1.15E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-4.46|P-value:2.66E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.85|P-value:2.15E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.36|P-value:3.21E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.25|P-value:3.37E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.12|P-value:5.36E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.20|P-value:4.09E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.04|P-value:1.93E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.31|P-value:2.67E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.37|P-value:2.13E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.58|P-value:9.30E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.29|P-value:2.90E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.39|P-value:1.98E-4 ID:SGTC_2445|Compound:5742597|FD-Score:2.98|P-value:8.94E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.26|P-value:3.26E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.29|P-value:4.12E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.51|P-value:1.23E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.09|P-value:8.58E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.07|P-value:8.95E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.97|P-value:9.21E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.98|P-value:8.83E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.01|P-value:7.92E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.21|P-value:8.80E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.55|P-value:1.07E-6 ID:SGTC_2993|Compound:9054257|FD-Score:4.62|P-value:7.50E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.55|P-value:1.05E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.14|P-value:5.09E-4

Top fitness defect scores for YOR137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_957 1187-1561 7.19 14.1 µM 4.13E-14 2 3.25E-13
2 SGTC_1385 3091-4834 4.85 14.1 µM 2.15E-7 RPP1 & pyrimidine depletion 4 6.08E-7
3 SGTC_2993 9054257 4.62 71.4 µM 7.50E-7 fatty acid desaturase (OLE1) 27 1.95E-6
4 SGTC_2989 9073649 4.55 71.4 µM 1.07E-6 20 2.72E-6
5 SGTC_452 diindolylmethane 4.51 8.0 µM 1.28E-6 RNA processing & uracil transport 5 3.23E-6
6 SGTC_68 0986-0284 4.00 82.8 µM 1.51E-5 70 3.21E-5
7 SGTC_826 1683-5028 3.84 118.0 µM 3.02E-5 18 6.13E-5
8 SGTC_154 3389-1638 3.82 511.1 µM 3.35E-5 25 6.74E-5
9 SGTC_687 k029-0044 3.72 34.9 µM 5.07E-5 PDR1 21 9.93E-5
10 SGTC_799 1310-0557 3.66 151.0 µM 6.51E-5 superoxide 32 1.25E-4
11 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.58 49.5 µM 9.30E-5 29 1.75E-4
12 SGTC_230 MPP+ 3.56 141.7 µM 9.95E-5 25 1.86E-4
13 SGTC_3038 9091290 3.55 49.5 µM 1.05E-4 24 1.96E-4
14 SGTC_2502 avocadyne acetate 3.51 18.6 µM 1.23E-4 43 2.26E-4
15 SGTC_347 4534-1311 3.47 26.2 µM 1.43E-4 RPP1 & pyrimidine depletion 22 2.61E-4
16 SGTC_151 3013-0144 3.45 2.3 µM 1.56E-4 iron homeostasis 49 2.83E-4
17 SGTC_595 3909-8003 3.40 73.7 µM 1.86E-4 30 3.34E-4
18 SGTC_2349 9023730 3.39 187.1 µM 1.98E-4 57 3.54E-4
19 SGTC_788 1182-0090 3.37 188.0 µM 2.08E-4 endomembrane recycling 113 3.70E-4
20 SGTC_2074 5212007 3.37 75.4 µM 2.13E-4 28 3.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.01E-9 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.099 8.15E-9 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
0.097 1.70E-8 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.093 6.18E-8 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.091 1.20E-7 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.090 1.78E-7 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.086 6.43E-7 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.085 7.77E-7 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.083 1.54E-6 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.082 2.12E-6 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.079 4.72E-6 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.076 9.71E-6 YLL015W BPT1 hom ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.073 2.40E-5 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.073 2.57E-5 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.073 2.59E-5 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy