HIPHOP chemogenomics database
YOR137C / SIA1 
Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR137C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.103 | 2.01E-9 | YLR190W | MMR1 | hom | Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p |
| 0.099 | 8.15E-9 | YER150W | SPI1 | hom | GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p |
| 0.097 | 1.70E-8 | YDR249C_p | YDR249C_p | hom | Putative protein of unknown function |
| 0.093 | 6.18E-8 | YOL038C-A_p | YOL038C-A_p | hom | Putative protein of unknown function; identified by SAGE analysis |
| 0.091 | 1.20E-7 | YBR144C_d | YBR144C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene |
| 0.090 | 1.78E-7 | YLR440C | SEC39 | het | Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope |
| 0.086 | 6.43E-7 | YPR025C | CCL1 | het | Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters |
| 0.085 | 7.77E-7 | YPL027W | SMA1 | hom | Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p |
| 0.083 | 1.54E-6 | YDR329C | PEX3 | hom | Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p |
| 0.082 | 2.12E-6 | YOL120C | RPL18A | het | Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication |
| 0.079 | 4.72E-6 | YKL187C | FAT3 | hom | Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies |
| 0.076 | 9.71E-6 | YLL015W | BPT1 | hom | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p |
| 0.073 | 2.40E-5 | YDL199C_p | YDL199C_p | hom | Putative transporter, member of the sugar porter family |
| 0.073 | 2.57E-5 | YNR068C_p | YNR068C_p | hom | Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form |
| 0.073 | 2.59E-5 | YMR221C_p | YMR221C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy |