YOR138C / RUP1

Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR138C / RUP1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.42|P-value:5.03E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.24|P-value:7.94E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.17|P-value:9.89E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:7.35|P-value:6.69E-13 ID:SGTC_507|Compound:nimesulide|FD-Score:4.91|P-value:1.09E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.82|P-value:9.98E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.26|P-value:8.56E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.82|P-value:1.18E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.73|P-value:1.43E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.54|P-value:3.31E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-4.06|P-value:3.89E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.82|P-value:1.01E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.56|P-value:3.12E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.31|P-value:6.28E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:6.88|P-value:1.64E-11 ID:SGTC_914|Compound:3820-6779|FD-Score:4.20|P-value:2.61E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.56|P-value:5.53E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.70|P-value:3.03E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.56|P-value:2.62E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.32|P-value:6.96E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.70|P-value:1.85E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.77|P-value:1.46E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.80|P-value:1.85E-6 ID:SGTC_2051|Compound:5263410|FD-Score:3.70|P-value:1.82E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.42|P-value:5.11E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.80|P-value:1.27E-4 ID:SGTC_2274|Compound:7947094|FD-Score:6.97|P-value:8.88E-12 ID:SGTC_2275|Compound:7947463|FD-Score:-3.44|P-value:4.02E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.24|P-value:2.24E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.23|P-value:9.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.63|P-value:2.42E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.14|P-value:3.39E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.22|P-value:8.53E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.90|P-value:8.73E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.35|P-value:6.45E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.83|P-value:1.14E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.27|P-value:8.23E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.56|P-value:2.66E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.35|P-value:5.48E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.31|P-value:7.41E-4 ID:SGTC_3355|Compound:9151058|FD-Score:4.40|P-value:1.14E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.42|P-value:5.03E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.24|P-value:7.94E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.17|P-value:9.89E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:7.35|P-value:6.69E-13 ID:SGTC_507|Compound:nimesulide|FD-Score:4.91|P-value:1.09E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.82|P-value:9.98E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.26|P-value:8.56E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.82|P-value:1.18E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.73|P-value:1.43E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.54|P-value:3.31E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-4.06|P-value:3.89E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.82|P-value:1.01E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.56|P-value:3.12E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.31|P-value:6.28E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:6.88|P-value:1.64E-11 ID:SGTC_914|Compound:3820-6779|FD-Score:4.20|P-value:2.61E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.56|P-value:5.53E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.70|P-value:3.03E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.56|P-value:2.62E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.32|P-value:6.96E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.70|P-value:1.85E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.77|P-value:1.46E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.80|P-value:1.85E-6 ID:SGTC_2051|Compound:5263410|FD-Score:3.70|P-value:1.82E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.42|P-value:5.11E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.80|P-value:1.27E-4 ID:SGTC_2274|Compound:7947094|FD-Score:6.97|P-value:8.88E-12 ID:SGTC_2275|Compound:7947463|FD-Score:-3.44|P-value:4.02E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.24|P-value:2.24E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.23|P-value:9.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.63|P-value:2.42E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.14|P-value:3.39E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.22|P-value:8.53E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.90|P-value:8.73E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.35|P-value:6.45E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.83|P-value:1.14E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.27|P-value:8.23E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.56|P-value:2.66E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.35|P-value:5.48E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.31|P-value:7.41E-4 ID:SGTC_3355|Compound:9151058|FD-Score:4.40|P-value:1.14E-5

Top fitness defect scores for YOR138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_432 NS 1619 7.35 61.3 µM 6.69E-13 1 1.01E-13
2 SGTC_2274 7947094 6.97 46.1 µM 8.88E-12 2 1.60E-12
3 SGTC_773 4358-1457 6.88 44.6 µM 1.64E-11 11 3.08E-12
4 SGTC_507 nimesulide 4.91 162.0 µM 1.09E-6 10 4.45E-7
5 SGTC_1936 st074407 4.80 74.3 µM 1.85E-6 DNA damage response 17 7.82E-7
6 SGTC_1134 3477-0009 4.70 42.5 µM 3.03E-6 27 1.33E-6
7 SGTC_1017 4239-0030 4.56 168.0 µM 5.53E-6 14 2.52E-6
8 SGTC_3355 9151058 4.40 44.0 µM 1.14E-5 RNA processing & uracil transport 6 5.47E-6
9 SGTC_2366 9070441 4.24 60.6 µM 2.24E-5 23 1.13E-5
10 SGTC_914 3820-6779 4.20 408.0 µM 2.61E-5 17 1.33E-5
11 SGTC_2587 piperic acid 4.14 92.2 µM 3.39E-5 18 1.75E-5
12 SGTC_2729 fluphenazine 3.90 10.7 µM 8.73E-5 15 4.82E-5
13 SGTC_2985 9022375 3.83 71.4 µM 1.14E-4 RPP1 & pyrimidine depletion 35 6.39E-5
14 SGTC_599 1935-0052 3.82 86.5 µM 1.18E-4 21 6.65E-5
15 SGTC_137 0438-0332 3.82 85.4 µM 1.20E-4 ubiquinone biosynthesis & proteasome 134 6.75E-5
16 SGTC_2266 7929956 3.80 200.0 µM 1.27E-4 39 7.22E-5
17 SGTC_62 0180-0423 3.79 3.2 µM 1.30E-4 60S ribosome export 23 7.40E-5
18 SGTC_1734 st037168 3.77 69.4 µM 1.46E-4 32 8.32E-5
19 SGTC_2051 5263410 3.70 176.0 µM 1.82E-4 20 1.06E-4
20 SGTC_1596 piperlongumine 3.70 63.0 µM 1.85E-4 22 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.44E-13 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.105 1.20E-9 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.103 2.06E-9 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.100 6.28E-9 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.100 7.47E-9 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.098 1.54E-8 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.097 1.66E-8 YPL128C TBF1 het Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation
0.092 1.03E-7 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.089 2.13E-7 YHR087W RTC3 hom Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
0.088 3.14E-7 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.088 3.17E-7 YAR003W SWD1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
0.085 8.15E-7 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.085 9.56E-7 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.084 9.79E-7 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.084 1.06E-6 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding