YOR139C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR139C / YOR139C

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.48|P-value:6.42E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.33|P-value:2.97E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.47|P-value:4.72E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.44|P-value:1.86E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.49|P-value:1.02E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.66|P-value:2.53E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.47|P-value:6.60E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.60|P-value:3.05E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.29|P-value:8.61E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.56|P-value:4.90E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:5.94|P-value:1.65E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.75|P-value:2.55E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.06|P-value:8.25E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.10|P-value:7.22E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.89|P-value:2.77E-6 ID:SGTC_1697|Compound:st025554|FD-Score:3.40|P-value:8.27E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.06|P-value:8.27E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-4.45|P-value:1.22E-5 ID:SGTC_1799|Compound:st045822|FD-Score:-3.51|P-value:4.17E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.43|P-value:7.51E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.41|P-value:5.90E-4 ID:SGTC_1933|Compound:st074711|FD-Score:5.19|P-value:7.10E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.98|P-value:1.12E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.39|P-value:8.50E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.14|P-value:6.26E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.79|P-value:4.26E-6 ID:SGTC_2181|Compound:6316240|FD-Score:3.70|P-value:3.04E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.98|P-value:1.81E-6 ID:SGTC_2438|Compound:5259590|FD-Score:3.86|P-value:1.75E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.07|P-value:8.03E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.52|P-value:4.00E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.70|P-value:3.07E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.83|P-value:3.54E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.40|P-value:8.31E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.44|P-value:7.28E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.37|P-value:9.03E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.99|P-value:1.07E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.06|P-value:8.23E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.43|P-value:5.39E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.91|P-value:9.94E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.71|P-value:2.92E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.57|P-value:3.43E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.67|P-value:2.43E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.48|P-value:6.46E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.48|P-value:6.42E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.33|P-value:2.97E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.47|P-value:4.72E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.44|P-value:1.86E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.49|P-value:1.02E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.66|P-value:2.53E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.47|P-value:6.60E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.60|P-value:3.05E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.29|P-value:8.61E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.56|P-value:4.90E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:5.94|P-value:1.65E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.75|P-value:2.55E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.06|P-value:8.25E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.10|P-value:7.22E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.89|P-value:2.77E-6 ID:SGTC_1697|Compound:st025554|FD-Score:3.40|P-value:8.27E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.06|P-value:8.27E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-4.45|P-value:1.22E-5 ID:SGTC_1799|Compound:st045822|FD-Score:-3.51|P-value:4.17E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.43|P-value:7.51E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.41|P-value:5.90E-4 ID:SGTC_1933|Compound:st074711|FD-Score:5.19|P-value:7.10E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.98|P-value:1.12E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.39|P-value:8.50E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.14|P-value:6.26E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.79|P-value:4.26E-6 ID:SGTC_2181|Compound:6316240|FD-Score:3.70|P-value:3.04E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.98|P-value:1.81E-6 ID:SGTC_2438|Compound:5259590|FD-Score:3.86|P-value:1.75E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.07|P-value:8.03E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.52|P-value:4.00E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.70|P-value:3.07E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.83|P-value:3.54E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.40|P-value:8.31E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.44|P-value:7.28E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.37|P-value:9.03E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.99|P-value:1.07E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.06|P-value:8.23E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.43|P-value:5.39E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.91|P-value:9.94E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.71|P-value:2.92E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.57|P-value:3.43E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.67|P-value:2.43E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.48|P-value:6.46E-4

Top fitness defect scores for YOR139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_923 1900-2434 5.94 73.3 µM 1.65E-8 RNA processing & uracil transport 10 1.46E-9
2 SGTC_1933 st074711 5.19 15.9 µM 7.10E-7 17 1.07E-7
3 SGTC_2268 7933382 4.98 153.8 µM 1.81E-6 17 3.12E-7
4 SGTC_1447 4239-0816 4.89 81.9 µM 2.77E-6 13 5.05E-7
5 SGTC_2661 dactinomycin 4.83 13.0 µM 3.54E-6 redox potentiating 7 6.68E-7
6 SGTC_2128 5255449 4.79 168.5 µM 4.26E-6 15 8.24E-7
7 SGTC_513 4245-1575 4.44 41.7 µM 1.86E-5 unfolded protein response 95 4.43E-6
8 SGTC_302 1094-0063 4.33 18.9 µM 2.97E-5 5 7.54E-6
9 SGTC_2086 5274770 4.14 176.6 µM 6.26E-5 21 1.77E-5
10 SGTC_1336 1486-0901 4.10 104.0 µM 7.22E-5 22 2.08E-5
11 SGTC_2597 laccaic acid a 4.07 100.0 µM 8.03E-5 33 2.35E-5
12 SGTC_3032 9089427 4.06 49.5 µM 8.23E-5 60S ribosome export 13 2.41E-5
13 SGTC_1136 pergolide 4.06 1.1 µM 8.25E-5 33 2.42E-5
14 SGTC_1787 fluconazole 4.06 80.0 µM 8.27E-5 iron homeostasis 24 2.43E-5
15 SGTC_2928 9011484 3.99 9.8 µM 1.07E-4 heme biosynthesis & mitochondrial translocase 37 3.26E-5
16 SGTC_1936 st074407 3.98 74.3 µM 1.12E-4 DNA damage response 34 3.42E-5
17 SGTC_2438 5259590 3.86 200.0 µM 1.75E-4 19 5.72E-5
18 SGTC_1049 3226-0134 3.75 66.0 µM 2.55E-4 33 8.75E-5
19 SGTC_3062 9077494 3.71 49.5 µM 2.92E-4 mitochondrial response to ROS 40 1.02E-4
20 SGTC_2181 6316240 3.70 54.3 µM 3.04E-4 25 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.32E-10 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.103 2.50E-9 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.096 2.83E-8 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.092 9.47E-8 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.079 4.96E-6 YPL130W SPO19 hom Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation
0.076 1.14E-5 YPL023C MET12 hom Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
0.075 1.43E-5 YOL007C CSI2 hom Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
0.074 1.88E-5 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.073 2.26E-5 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.071 4.37E-5 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.068 8.33E-5 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.065 1.55E-4 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.065 1.74E-4 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.064 2.25E-4 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.063 2.66E-4 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1