YOR140W / SFL1

Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR140W / SFL1

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.35|P-value:3.60E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.41|P-value:3.20E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.11|P-value:9.43E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.31|P-value:4.72E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:5.09|P-value:1.47E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.59|P-value:1.62E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.50|P-value:2.03E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.11|P-value:8.41E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.73|P-value:8.20E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.77|P-value:7.58E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:3.34|P-value:3.79E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.68|P-value:1.17E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-9.10|P-value:3.43E-20 ID:SGTC_917|Compound:harmaline|FD-Score:4.15|P-value:1.44E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:5.81|P-value:2.45E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.45|P-value:4.19E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.00|P-value:2.71E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.17|P-value:1.30E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.91|P-value:3.98E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-3.30|P-value:4.76E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.71|P-value:9.06E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.49|P-value:2.11E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.59|P-value:1.85E-6 ID:SGTC_1827|Compound:berberine|FD-Score:3.64|P-value:1.19E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.47|P-value:2.33E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.71|P-value:9.00E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.33|P-value:3.83E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.12|P-value:8.27E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.32|P-value:4.52E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.27|P-value:4.83E-4 ID:SGTC_2071|Compound:5230951|FD-Score:5.28|P-value:5.21E-8 ID:SGTC_2144|Compound:5628481|FD-Score:3.43|P-value:2.71E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:5.99E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.14|P-value:8.35E-4 ID:SGTC_2318|Compound:6029776|FD-Score:5.48|P-value:1.68E-8 ID:SGTC_2333|Compound:9017922|FD-Score:-3.45|P-value:2.81E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.84|P-value:5.36E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.15|P-value:2.88E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.38|P-value:5.00E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.76|P-value:8.37E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-3.26|P-value:5.64E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.38|P-value:3.58E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.02|P-value:2.46E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.37|P-value:3.34E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.35|P-value:3.60E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.41|P-value:3.20E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.11|P-value:9.43E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.31|P-value:4.72E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:5.09|P-value:1.47E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.59|P-value:1.62E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.50|P-value:2.03E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.11|P-value:8.41E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.73|P-value:8.20E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.77|P-value:7.58E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:3.34|P-value:3.79E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.68|P-value:1.17E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-9.10|P-value:3.43E-20 ID:SGTC_917|Compound:harmaline|FD-Score:4.15|P-value:1.44E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:5.81|P-value:2.45E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.45|P-value:4.19E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.00|P-value:2.71E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.17|P-value:1.30E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.91|P-value:3.98E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-3.30|P-value:4.76E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.71|P-value:9.06E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.49|P-value:2.11E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.59|P-value:1.85E-6 ID:SGTC_1827|Compound:berberine|FD-Score:3.64|P-value:1.19E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.47|P-value:2.33E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.71|P-value:9.00E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.33|P-value:3.83E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.12|P-value:8.27E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.32|P-value:4.52E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.27|P-value:4.83E-4 ID:SGTC_2071|Compound:5230951|FD-Score:5.28|P-value:5.21E-8 ID:SGTC_2144|Compound:5628481|FD-Score:3.43|P-value:2.71E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:5.99E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.14|P-value:8.35E-4 ID:SGTC_2318|Compound:6029776|FD-Score:5.48|P-value:1.68E-8 ID:SGTC_2333|Compound:9017922|FD-Score:-3.45|P-value:2.81E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.84|P-value:5.36E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.15|P-value:2.88E-10 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.38|P-value:5.00E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.76|P-value:8.37E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-3.26|P-value:5.64E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.38|P-value:3.58E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.02|P-value:2.46E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.37|P-value:3.34E-4

Top fitness defect scores for YOR140W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2573 2',4'-dihydroxychalcone 6.15 15.0 µM 2.88E-10 12 3.87E-10
2 SGTC_1030 k029-0042 5.81 36.7 µM 2.45E-9 TSC3-RPN4 6 3.20E-9
3 SGTC_2318 6029776 5.48 164.0 µM 1.68E-8 9 2.15E-8
4 SGTC_2071 5230951 5.28 39.9 µM 5.21E-8 TSC3-RPN4 3 6.57E-8
5 SGTC_580 1123-0028 5.09 41.0 µM 1.47E-7 DNA damage response 11 1.83E-7
6 SGTC_887 0885-0007 4.77 9.6 µM 7.58E-7 endomembrane recycling 23 9.23E-7
7 SGTC_1767 st044992 4.59 70.3 µM 1.85E-6 12 2.22E-6
8 SGTC_2587 piperic acid 4.38 92.2 µM 5.00E-6 16 5.95E-6
9 SGTC_1237 0330-0133 4.17 46.1 µM 1.30E-5 ergosterol biosynthesis 20 1.53E-5
10 SGTC_917 harmaline 4.15 728.1 nM 1.44E-5 ergosterol biosynthesis 23 1.69E-5
11 SGTC_2985 9022375 4.02 71.4 µM 2.46E-5 RPP1 & pyrimidine depletion 28 2.86E-5
12 SGTC_1048 3161-0300 4.00 24.5 µM 2.71E-5 22 3.16E-5
13 SGTC_1616 st002734 3.91 56.1 µM 3.98E-5 32 4.61E-5
14 SGTC_2342 7990637 3.84 118.9 µM 5.36E-5 RNA processing & uracil transport 40 6.18E-5
15 SGTC_855 0428-0020 3.73 25.0 µM 8.20E-5 Golgi 27 9.41E-5
16 SGTC_1867 st057372 3.71 64.0 µM 9.00E-5 12 1.03E-4
17 SGTC_1680 diphenhydramine 3.71 100.0 µM 9.06E-5 NEO1 36 1.04E-4
18 SGTC_1827 berberine 3.64 7.2 µM 1.19E-4 60S ribosome export 25 1.36E-4
19 SGTC_668 1682-0499 3.50 62.6 µM 2.03E-4 39 2.31E-4
20 SGTC_1703 st026983 3.49 48.3 µM 2.11E-4 19 2.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.08E-15 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.106 7.13E-10 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.103 2.42E-9 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.096 2.15E-8 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.095 3.01E-8 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.095 3.96E-8 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
0.094 5.59E-8 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.092 1.00E-7 YLR081W GAL2 hom Galactose permease, required for utilization of galactose; also able to transport glucose
0.087 4.65E-7 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.087 5.13E-7 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.086 5.41E-7 YER181C_d YER181C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.083 1.70E-6 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.082 2.25E-6 YKL167C MRP49 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.078 5.92E-6 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.076 9.25E-6 YMR160W YMR160W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress