YOR141C / ARP8

Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR141C / ARP8

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-5.47|P-value:9.98E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:9.62|P-value:1.63E-20 ID:SGTC_67|Compound:0335-0847|FD-Score:5.55|P-value:4.97E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:4.65|P-value:3.94E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.07|P-value:5.55E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:6.05|P-value:3.32E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:3.48|P-value:4.08E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:5.25|P-value:2.29E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:5.77|P-value:1.53E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.54|P-value:3.33E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.76|P-value:2.40E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.71|P-value:2.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.48|P-value:7.18E-8 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.28|P-value:9.25E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.10|P-value:6.85E-12 ID:SGTC_800|Compound:3448-7362|FD-Score:12.00|P-value:9.06E-31 ID:SGTC_802|Compound:4112-3352|FD-Score:4.16|P-value:3.17E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.25|P-value:8.88E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.42|P-value:1.10E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.64|P-value:2.36E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.24|P-value:9.18E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.91|P-value:1.19E-6 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.22|P-value:9.69E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.32|P-value:6.98E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.50|P-value:3.87E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.70|P-value:3.24E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.53|P-value:4.00E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.31|P-value:8.47E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.29|P-value:9.14E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.37|P-value:6.01E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.42|P-value:5.79E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.36|P-value:6.06E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.49|P-value:8.08E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.67|P-value:4.61E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.51|P-value:9.20E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-4.35|P-value:1.79E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.46|P-value:9.12E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.55|P-value:3.18E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.19|P-value:2.88E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.50|P-value:3.77E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.50|P-value:3.80E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.97|P-value:8.22E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.51|P-value:3.65E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.81|P-value:1.50E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.33|P-value:6.78E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.23|P-value:9.41E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.59|P-value:3.31E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.84|P-value:1.31E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:5.29|P-value:1.90E-7 ID:SGTC_2556|Compound:citropten|FD-Score:5.06|P-value:5.87E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.63|P-value:1.39E-20 ID:SGTC_2607|Compound:solasodine|FD-Score:3.56|P-value:3.05E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.97|P-value:1.13E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:-5.24|P-value:3.08E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:15.20|P-value:2.26E-48 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.67|P-value:2.11E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.71|P-value:3.12E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.58|P-value:6.87E-6 ID:SGTC_2716|Compound:st080858|FD-Score:5.04|P-value:6.50E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.35|P-value:1.82E-7 ID:SGTC_2912|Compound:7964298|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.57|P-value:3.48E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.32|P-value:8.11E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.34|P-value:7.77E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.31|P-value:1.75E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-4.24|P-value:2.78E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.06|P-value:5.82E-5 ID:SGTC_3266|Compound:9136860|FD-Score:4.63|P-value:4.38E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.47|P-value:9.98E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:9.62|P-value:1.63E-20 ID:SGTC_67|Compound:0335-0847|FD-Score:5.55|P-value:4.97E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:4.65|P-value:3.94E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.07|P-value:5.55E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:6.05|P-value:3.32E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:3.48|P-value:4.08E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:5.25|P-value:2.29E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:5.77|P-value:1.53E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.54|P-value:3.33E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.76|P-value:2.40E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.71|P-value:2.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.48|P-value:7.18E-8 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.28|P-value:9.25E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.10|P-value:6.85E-12 ID:SGTC_800|Compound:3448-7362|FD-Score:12.00|P-value:9.06E-31 ID:SGTC_802|Compound:4112-3352|FD-Score:4.16|P-value:3.17E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.25|P-value:8.88E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.42|P-value:1.10E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.64|P-value:2.36E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.24|P-value:9.18E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.91|P-value:1.19E-6 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.22|P-value:9.69E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.32|P-value:6.98E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.50|P-value:3.87E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.70|P-value:3.24E-6 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.53|P-value:4.00E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.31|P-value:8.47E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.29|P-value:9.14E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.37|P-value:6.01E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.42|P-value:5.79E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.36|P-value:6.06E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.49|P-value:8.08E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.67|P-value:4.61E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.51|P-value:9.20E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-4.35|P-value:1.79E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.46|P-value:9.12E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.55|P-value:3.18E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.19|P-value:2.88E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.50|P-value:3.77E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.50|P-value:3.80E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.97|P-value:8.22E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.51|P-value:3.65E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.81|P-value:1.50E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.33|P-value:6.78E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.23|P-value:9.41E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.59|P-value:3.31E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.84|P-value:1.31E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:5.29|P-value:1.90E-7 ID:SGTC_2556|Compound:citropten|FD-Score:5.06|P-value:5.87E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.63|P-value:1.39E-20 ID:SGTC_2607|Compound:solasodine|FD-Score:3.56|P-value:3.05E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.97|P-value:1.13E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:-5.24|P-value:3.08E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:15.20|P-value:2.26E-48 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.67|P-value:2.11E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.71|P-value:3.12E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.58|P-value:6.87E-6 ID:SGTC_2716|Compound:st080858|FD-Score:5.04|P-value:6.50E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.35|P-value:1.82E-7 ID:SGTC_2912|Compound:7964298|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.57|P-value:3.48E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.32|P-value:8.11E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.34|P-value:7.77E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.31|P-value:1.75E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-4.24|P-value:2.78E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.06|P-value:5.82E-5 ID:SGTC_3266|Compound:9136860|FD-Score:4.63|P-value:4.38E-6

Top fitness defect scores for YOR141C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2617 dihydrotanshinone i 15.20 20.8 µM 2.26E-48 copper-dependent oxidative stress 1 1.21E-52
2 SGTC_800 3448-7362 12.00 155.0 µM 9.06E-31 translation 2 2.13E-33
3 SGTC_2582 agaric acid 9.63 100.0 µM 1.39E-20 redox potentiating 74 2.86E-22
4 SGTC_58 0957-0393 9.62 9.0 µM 1.63E-20 cell wall 89 3.39E-22
5 SGTC_143 4032-1194 6.05 15.7 µM 3.32E-9 19 7.38E-10
6 SGTC_212 3807-4682 5.77 38.8 µM 1.53E-8 tubulin folding & SWR complex 28 3.89E-9
7 SGTC_67 0335-0847 5.55 266.0 µM 4.97E-8 ubiquinone biosynthesis & proteasome 72 1.40E-8
8 SGTC_625 k213-0058 5.48 121.0 µM 7.18E-8 translation 48 2.10E-8
9 SGTC_2531 methyl deoxycholate 5.29 70.1 µM 1.90E-7 8 6.04E-8
10 SGTC_210 3551-0445 5.25 56.8 µM 2.29E-7 34 7.41E-8
11 SGTC_138 0850-0259 5.07 40.9 µM 5.55E-7 cell wall 141 1.94E-7
12 SGTC_2556 citropten 5.06 84.6 µM 5.87E-7 8 2.06E-7
13 SGTC_2716 st080858 5.04 38.6 µM 6.50E-7 60S ribosome export 5 2.30E-7
14 SGTC_1160 4092-0570 4.91 10.5 µM 1.19E-6 plasma membrane duress 23 4.46E-7
15 SGTC_304 1310-0298 4.76 97.0 µM 2.40E-6 cell wall 34 9.52E-7
16 SGTC_2651 1327-0036 4.71 5.0 µM 3.12E-6 126 1.26E-6
17 SGTC_1266 0828-0227 4.70 32.9 µM 3.24E-6 11 1.32E-6
18 SGTC_86 0417-1630 4.65 471.9 µM 3.94E-6 ubiquinone biosynthesis & proteasome 122 1.63E-6
19 SGTC_3266 9136860 4.63 49.5 µM 4.38E-6 cell wall 33 1.83E-6
20 SGTC_1707 st032323 4.49 6.3 µM 8.08E-6 DNA damage response 45 3.56E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.269 6.64E-57 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.249 1.84E-48 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.230 1.42E-41 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.214 3.51E-36 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.205 2.57E-33 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.201 4.83E-32 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.197 8.12E-31 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.193 2.26E-29 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.187 1.06E-27 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.184 5.66E-27 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.182 1.90E-26 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.178 2.34E-25 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.176 1.12E-24 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.176 1.25E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.175 2.00E-24 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C