YOR143C / THI80

Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR143C / THI80

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:-2.73|P-value:7.04E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.92|P-value:3.29E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.30|P-value:2.28E-7 ID:SGTC_109|Compound:0132-0036|FD-Score:3.30|P-value:5.50E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:2.81|P-value:4.89E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.25|P-value:7.52E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-2.85|P-value:4.45E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.88|P-value:3.82E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-2.81|P-value:5.18E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.36|P-value:4.32E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:2.80|P-value:4.98E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.24|P-value:7.04E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-2.93|P-value:3.14E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.47|P-value:2.33E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:3.80|P-value:4.19E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.92|P-value:4.33E-9 ID:SGTC_781|Compound:4335-2806|FD-Score:-7.36|P-value:3.80E-18 ID:SGTC_792|Compound:4534-1957|FD-Score:-4.87|P-value:6.18E-9 ID:SGTC_798|Compound:1287-0182|FD-Score:2.75|P-value:6.33E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.80|P-value:4.12E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.94|P-value:2.97E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.00|P-value:2.18E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.32|P-value:4.97E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.52|P-value:1.80E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-2.66|P-value:9.40E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.30|P-value:5.47E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.26|P-value:6.68E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.90|P-value:3.36E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.00|P-value:2.18E-4 ID:SGTC_1638|Compound:st008370|FD-Score:2.92|P-value:3.07E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.09|P-value:1.45E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.60|P-value:1.21E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.46|P-value:2.51E-5 ID:SGTC_1829|Compound:berberine|FD-Score:2.66|P-value:8.98E-4 ID:SGTC_1862|Compound:st057513|FD-Score:2.83|P-value:4.50E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.36|P-value:4.12E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.26|P-value:6.64E-5 ID:SGTC_2080|Compound:5212524|FD-Score:-3.12|P-value:1.34E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.04|P-value:1.82E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.72|P-value:7.17E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.17|P-value:9.92E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.33|P-value:4.79E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.98|P-value:1.50E-6 ID:SGTC_2427|Compound:5545055|FD-Score:2.93|P-value:2.92E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.32|P-value:5.35E-5 ID:SGTC_2436|Compound:5633522|FD-Score:4.40|P-value:1.23E-7 ID:SGTC_2511|Compound:berberine|FD-Score:3.16|P-value:1.03E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.66|P-value:9.48E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.92|P-value:3.29E-4 ID:SGTC_2997|Compound:9067075|FD-Score:2.92|P-value:3.08E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.80|P-value:5.09E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.37|P-value:3.89E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.32|P-value:4.85E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.18|P-value:9.57E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.71|P-value:7.22E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.37|P-value:3.83E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:-2.73|P-value:7.04E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.92|P-value:3.29E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.30|P-value:2.28E-7 ID:SGTC_109|Compound:0132-0036|FD-Score:3.30|P-value:5.50E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:2.81|P-value:4.89E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.25|P-value:7.52E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:-2.85|P-value:4.45E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.88|P-value:3.82E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-2.81|P-value:5.18E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.36|P-value:4.32E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:2.80|P-value:4.98E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.24|P-value:7.04E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-2.93|P-value:3.14E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.47|P-value:2.33E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:3.80|P-value:4.19E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:-4.92|P-value:4.33E-9 ID:SGTC_781|Compound:4335-2806|FD-Score:-7.36|P-value:3.80E-18 ID:SGTC_792|Compound:4534-1957|FD-Score:-4.87|P-value:6.18E-9 ID:SGTC_798|Compound:1287-0182|FD-Score:2.75|P-value:6.33E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.80|P-value:4.12E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.94|P-value:2.97E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.00|P-value:2.18E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.32|P-value:4.97E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.52|P-value:1.80E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-2.66|P-value:9.40E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.30|P-value:5.47E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.26|P-value:6.68E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.90|P-value:3.36E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.00|P-value:2.18E-4 ID:SGTC_1638|Compound:st008370|FD-Score:2.92|P-value:3.07E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.09|P-value:1.45E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.60|P-value:1.21E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.46|P-value:2.51E-5 ID:SGTC_1829|Compound:berberine|FD-Score:2.66|P-value:8.98E-4 ID:SGTC_1862|Compound:st057513|FD-Score:2.83|P-value:4.50E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.36|P-value:4.12E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.26|P-value:6.64E-5 ID:SGTC_2080|Compound:5212524|FD-Score:-3.12|P-value:1.34E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.04|P-value:1.82E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.72|P-value:7.17E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.17|P-value:9.92E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.33|P-value:4.79E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.98|P-value:1.50E-6 ID:SGTC_2427|Compound:5545055|FD-Score:2.93|P-value:2.92E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.32|P-value:5.35E-5 ID:SGTC_2436|Compound:5633522|FD-Score:4.40|P-value:1.23E-7 ID:SGTC_2511|Compound:berberine|FD-Score:3.16|P-value:1.03E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.66|P-value:9.48E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.92|P-value:3.29E-4 ID:SGTC_2997|Compound:9067075|FD-Score:2.92|P-value:3.08E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.80|P-value:5.09E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.37|P-value:3.89E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.32|P-value:4.85E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.18|P-value:9.57E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.71|P-value:7.22E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.37|P-value:3.83E-5

Top fitness defect scores for YOR143C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2436 5633522 4.40 8.1 µM 1.23E-7 8 5.38E-6 0.32
2 SGTC_100 0086-0128 4.30 49.6 µM 2.28E-7 copper-dependent oxidative stress 4 8.47E-6 0.02
3 SGTC_2425 5628681 3.98 7.8 µM 1.50E-6 5 3.41E-5 0.26
4 SGTC_803 4488-1585 3.80 147.0 µM 4.12E-6 5 7.18E-5 0.22
5 SGTC_768 0384-0033 3.80 77.3 µM 4.19E-6 fatty acid desaturase (OLE1) 22 7.27E-5 0.16
6 SGTC_1678 st019265 3.60 80.2 µM 1.21E-5 60S ribosome export 8 1.60E-4 0.16
7 SGTC_1051 3253-3903 3.52 78.0 µM 1.80E-5 9 2.14E-4 0.01
8 SGTC_729 4092-0585 3.47 94.1 µM 2.33E-5 3 2.59E-4 0.02
9 SGTC_1709 st033179 3.46 39.1 µM 2.51E-5 4 2.74E-4 0.40
10 SGTC_3209 9113616 3.37 49.5 µM 3.83E-5 12 3.74E-4 0.02
11 SGTC_3137 9097352 3.37 49.5 µM 3.89E-5 15 3.78E-4 0.00
12 SGTC_1991 st073000 3.36 8.9 µM 4.12E-5 NEO1 23 3.95E-4 0.05
13 SGTC_2280 7785178 3.33 200.0 µM 4.79E-5 5 4.41E-4 0.25
14 SGTC_3174 9107204 3.32 49.5 µM 4.85E-5 ERG2 4 4.46E-4 0.20
15 SGTC_943 3253-1379 3.32 105.0 µM 4.97E-5 13 4.54E-4 0.08
16 SGTC_1093 fluphenazine 3.30 8.0 µM 5.47E-5 11 4.87E-4 0.03
17 SGTC_109 0132-0036 3.30 33.7 µM 5.50E-5 9 4.89E-4 0.02
18 SGTC_2061 5245884 3.26 81.0 µM 6.64E-5 tubulin folding & SWR complex 13 5.63E-4 0.21
19 SGTC_1121 fusaric acid 3.26 630.5 nM 6.68E-5 9 5.65E-4 0.13
20 SGTC_679 0422-0091 3.24 41.4 µM 7.04E-5 Golgi 22 5.88E-4 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 2.03E-11 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.097 1.54E-8 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.096 2.41E-8 YCR083W TRX3 hom Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
0.092 1.04E-7 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.089 2.63E-7 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.082 2.15E-6 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.081 2.49E-6 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.079 4.35E-6 YOR341W RPA190 het RNA polymerase I largest subunit A190
0.077 8.00E-6 YAL067W-A_p YAL067W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.073 2.23E-5 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.072 2.82E-5 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.071 3.53E-5 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.071 4.30E-5 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.070 5.39E-5 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.069 5.72E-5 YGL023C PIB2 hom Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27