YOR146W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR146W / YOR146W

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:4.11|P-value:1.49E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.83|P-value:3.76E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.49|P-value:3.99E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:8.67|P-value:1.72E-14 ID:SGTC_312|Compound:4092-0653|FD-Score:4.52|P-value:3.56E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.56|P-value:4.43E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.94|P-value:2.64E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.34|P-value:6.83E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.31|P-value:7.59E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-4.28|P-value:1.18E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.64|P-value:2.30E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.38|P-value:1.18E-6 ID:SGTC_844|Compound:0330-0132|FD-Score:3.53|P-value:9.39E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.72|P-value:5.23E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.48|P-value:4.16E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.38|P-value:8.42E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.54|P-value:9.12E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.78|P-value:4.42E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.58|P-value:2.86E-5 ID:SGTC_1553|Compound:gossypol|FD-Score:3.76|P-value:4.61E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.17|P-value:1.74E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.40|P-value:5.49E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.67|P-value:6.07E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.80|P-value:4.07E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.83|P-value:3.70E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.89|P-value:4.20E-4 ID:SGTC_1932|Compound:st074806|FD-Score:6.24|P-value:2.35E-8 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.75|P-value:4.75E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.73|P-value:5.15E-4 ID:SGTC_2331|Compound:7980721|FD-Score:5.28|P-value:1.85E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-4.69|P-value:2.80E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.95|P-value:2.58E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.57|P-value:8.29E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.96|P-value:1.66E-12 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.85|P-value:3.56E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.67|P-value:8.22E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.76|P-value:1.47E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.34|P-value:6.83E-5 ID:SGTC_2891|Compound:9063876|FD-Score:4.28|P-value:8.38E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.61|P-value:9.80E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.17|P-value:1.21E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.46|P-value:4.51E-5 ID:SGTC_2996|Compound:9066192|FD-Score:3.73|P-value:5.14E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.60|P-value:2.65E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.82|P-value:1.67E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.81|P-value:5.40E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.17|P-value:4.29E-6 ID:SGTC_3280|Compound:9140961|FD-Score:-4.07|P-value:2.39E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.77|P-value:6.16E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.11|P-value:1.49E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.83|P-value:3.76E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.49|P-value:3.99E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:8.67|P-value:1.72E-14 ID:SGTC_312|Compound:4092-0653|FD-Score:4.52|P-value:3.56E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.56|P-value:4.43E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.94|P-value:2.64E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.34|P-value:6.83E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:4.31|P-value:7.59E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-4.28|P-value:1.18E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.64|P-value:2.30E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.38|P-value:1.18E-6 ID:SGTC_844|Compound:0330-0132|FD-Score:3.53|P-value:9.39E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.72|P-value:5.23E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.48|P-value:4.16E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.38|P-value:8.42E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.54|P-value:9.12E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.78|P-value:4.42E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.58|P-value:2.86E-5 ID:SGTC_1553|Compound:gossypol|FD-Score:3.76|P-value:4.61E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.17|P-value:1.74E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.40|P-value:5.49E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.67|P-value:6.07E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.80|P-value:4.07E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.83|P-value:3.70E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.89|P-value:4.20E-4 ID:SGTC_1932|Compound:st074806|FD-Score:6.24|P-value:2.35E-8 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.75|P-value:4.75E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.73|P-value:5.15E-4 ID:SGTC_2331|Compound:7980721|FD-Score:5.28|P-value:1.85E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-4.69|P-value:2.80E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.95|P-value:2.58E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.57|P-value:8.29E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.96|P-value:1.66E-12 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.85|P-value:3.56E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.67|P-value:8.22E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.76|P-value:1.47E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.34|P-value:6.83E-5 ID:SGTC_2891|Compound:9063876|FD-Score:4.28|P-value:8.38E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.61|P-value:9.80E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.17|P-value:1.21E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.46|P-value:4.51E-5 ID:SGTC_2996|Compound:9066192|FD-Score:3.73|P-value:5.14E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.60|P-value:2.65E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.82|P-value:1.67E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.81|P-value:5.40E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.17|P-value:4.29E-6 ID:SGTC_3280|Compound:9140961|FD-Score:-4.07|P-value:2.39E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-3.77|P-value:6.16E-4

Top fitness defect scores for YOR146W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 8.67 7.5 µM 1.72E-14 18 2.09E-18 0.20
2 SGTC_2651 1327-0036 7.96 5.0 µM 1.66E-12 21 8.37E-16 0.04
3 SGTC_1932 st074806 6.24 40.9 µM 2.35E-8 3 2.24E-10 0.67
4 SGTC_800 3448-7362 5.38 155.0 µM 1.18E-6 translation 29 3.68E-8 0.06
5 SGTC_2331 7980721 5.28 200.0 µM 1.85E-6 6 6.63E-8 0.28
6 SGTC_2786 7743617 4.76 45.5 µM 1.47E-5 3 9.75E-7 0.29
7 SGTC_791 1348-1292 4.64 225.0 µM 2.30E-5 2 1.74E-6 1.02
8 SGTC_3180 9109287 4.60 49.5 µM 2.65E-5 1 2.10E-6 0.50
9 SGTC_1466 k213-0079 4.58 57.5 µM 2.86E-5 4 2.31E-6 0.02
10 SGTC_312 4092-0653 4.52 6.8 µM 3.56E-5 ergosterol depletion effects on membrane 26 3.07E-6 0.05
11 SGTC_149 3970-0822 4.49 46.1 µM 3.99E-5 tubulin folding & SWR complex 7 3.57E-6 0.24
12 SGTC_1032 k061-1018 4.48 98.7 µM 4.16E-5 1 3.77E-6 0.41
13 SGTC_2985 9022375 4.46 71.4 µM 4.51E-5 RPP1 & pyrimidine depletion 5 4.18E-6 0.14
14 SGTC_1714 st033236 4.40 13.6 µM 5.49E-5 6 5.38E-6 0.41
15 SGTC_2812 7970281 4.34 58.4 µM 6.83E-5 5 7.15E-6 0.09
16 SGTC_756 0508-1999 4.34 28.3 µM 6.83E-5 RPP1 & pyrimidine depletion 8 7.15E-6 0.09
17 SGTC_770 0389-1121 4.31 67.2 µM 7.59E-5 RPP1 & pyrimidine depletion 8 8.18E-6 0.12
18 SGTC_2891 9063876 4.28 19.5 µM 8.38E-5 1 9.31E-6 0.75
19 SGTC_2944 9067346 4.17 25.6 µM 1.21E-4 11 1.50E-5 0.03
20 SGTC_104 0074-0074 4.11 591.0 µM 1.49E-4 12 1.96E-5 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 1.68E-44 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.233 1.11E-42 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.197 8.56E-31 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.186 1.30E-27 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.178 3.06E-25 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.175 1.51E-24 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.169 6.45E-23 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.166 3.11E-22 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.166 3.47E-22 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.161 6.72E-21 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.160 1.00E-20 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.159 2.34E-20 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.158 4.17E-20 YIL061C SNP1 het Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress
0.157 6.75E-20 YER025W GCD11 het Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.155 1.97E-19 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex