YOR147W / MDM32

Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR147W / MDM32

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:4.15|P-value:2.43E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:5.78|P-value:8.45E-9 ID:SGTC_50|Compound:0929-0078|FD-Score:3.32|P-value:5.74E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.95|P-value:5.44E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.00|P-value:4.50E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:8.01|P-value:3.25E-15 ID:SGTC_433|Compound:pimozide|FD-Score:-3.61|P-value:2.77E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.13|P-value:2.66E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.11|P-value:2.87E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.33|P-value:5.54E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.11|P-value:2.89E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.32|P-value:5.65E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.98|P-value:4.88E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.53|P-value:2.75E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-4.14|P-value:3.57E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.85|P-value:8.15E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.31|P-value:5.88E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-4.25|P-value:2.29E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-7.63|P-value:1.02E-13 ID:SGTC_1252|Compound:0493-0875|FD-Score:-7.06|P-value:5.25E-12 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.41|P-value:4.08E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.44|P-value:3.70E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.22|P-value:1.82E-5 ID:SGTC_1908|Compound:st060353|FD-Score:5.66|P-value:1.72E-8 ID:SGTC_1912|Compound:st060209|FD-Score:4.83|P-value:1.21E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.76|P-value:1.69E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.22|P-value:7.88E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.09|P-value:3.11E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.91|P-value:8.15E-7 ID:SGTC_2298|Compound:7976326|FD-Score:4.05|P-value:3.77E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.21|P-value:8.27E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.38|P-value:6.18E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.39|P-value:5.81E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.56|P-value:3.26E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.13|P-value:2.62E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.34|P-value:5.27E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.38|P-value:6.02E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.98|P-value:4.97E-5 ID:SGTC_3004|Compound:9076122|FD-Score:6.79|P-value:1.85E-11 ID:SGTC_3194|Compound:9111903|FD-Score:6.32|P-value:3.63E-10 ID:SGTC_3233|Compound:9132340|FD-Score:4.80|P-value:1.38E-6 ID:SGTC_3284|Compound:9108171|FD-Score:4.64|P-value:2.89E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.58|P-value:3.06E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.15|P-value:2.43E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:5.78|P-value:8.45E-9 ID:SGTC_50|Compound:0929-0078|FD-Score:3.32|P-value:5.74E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.95|P-value:5.44E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.00|P-value:4.50E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:8.01|P-value:3.25E-15 ID:SGTC_433|Compound:pimozide|FD-Score:-3.61|P-value:2.77E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.13|P-value:2.66E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.11|P-value:2.87E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.33|P-value:5.54E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.11|P-value:2.89E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.32|P-value:5.65E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.98|P-value:4.88E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.53|P-value:2.75E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-4.14|P-value:3.57E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.85|P-value:8.15E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.31|P-value:5.88E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-4.25|P-value:2.29E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-7.63|P-value:1.02E-13 ID:SGTC_1252|Compound:0493-0875|FD-Score:-7.06|P-value:5.25E-12 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.41|P-value:4.08E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.44|P-value:3.70E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.22|P-value:1.82E-5 ID:SGTC_1908|Compound:st060353|FD-Score:5.66|P-value:1.72E-8 ID:SGTC_1912|Compound:st060209|FD-Score:4.83|P-value:1.21E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.76|P-value:1.69E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.22|P-value:7.88E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.09|P-value:3.11E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.91|P-value:8.15E-7 ID:SGTC_2298|Compound:7976326|FD-Score:4.05|P-value:3.77E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.21|P-value:8.27E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.38|P-value:6.18E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.39|P-value:5.81E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.56|P-value:3.26E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.13|P-value:2.62E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.34|P-value:5.27E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.38|P-value:6.02E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.98|P-value:4.97E-5 ID:SGTC_3004|Compound:9076122|FD-Score:6.79|P-value:1.85E-11 ID:SGTC_3194|Compound:9111903|FD-Score:6.32|P-value:3.63E-10 ID:SGTC_3233|Compound:9132340|FD-Score:4.80|P-value:1.38E-6 ID:SGTC_3284|Compound:9108171|FD-Score:4.64|P-value:2.89E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.58|P-value:3.06E-4

Top fitness defect scores for YOR147W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_314 1671-0008 8.01 2.7 µM 3.25E-15 2 5.94E-16
2 SGTC_3004 9076122 6.79 71.4 µM 1.85E-11 4 5.66E-12
3 SGTC_3194 9111903 6.32 49.5 µM 3.63E-10 5 1.32E-10
4 SGTC_49 0717-0965 5.78 32.1 µM 8.45E-9 60S ribosome export 3 3.67E-9
5 SGTC_1908 st060353 5.66 56.5 µM 1.72E-8 RPP1 & pyrimidine depletion 12 7.78E-9
6 SGTC_2082 5219693 4.91 150.0 µM 8.15E-7 RNA processing & uracil transport 8 4.58E-7
7 SGTC_1912 st060209 4.83 90.8 µM 1.21E-6 17 6.95E-7
8 SGTC_3233 9132340 4.80 49.5 µM 1.38E-6 6 7.98E-7
9 SGTC_1916 st067606 4.76 49.2 µM 1.69E-6 19 9.87E-7
10 SGTC_3284 9108171 4.64 64.9 µM 2.89E-6 13 1.74E-6
11 SGTC_1867 st057372 4.22 64.0 µM 1.82E-5 5 1.21E-5
12 SGTC_25 0118-0223 4.15 35.7 µM 2.43E-5 10 1.64E-5
13 SGTC_2777 climbazole 4.13 1.5 µM 2.62E-5 iron homeostasis 40 1.78E-5
14 SGTC_436 n,n-dimethylsphingosine 4.13 3.3 µM 2.66E-5 22 1.80E-5
15 SGTC_452 diindolylmethane 4.11 8.0 µM 2.87E-5 RNA processing & uracil transport 8 1.96E-5
16 SGTC_806 3966-4455 4.11 5.9 µM 2.89E-5 17 1.97E-5
17 SGTC_2063 5246145 4.09 200.0 µM 3.11E-5 20 2.13E-5
18 SGTC_2298 7976326 4.05 193.8 µM 3.77E-5 8 2.60E-5
19 SGTC_236 1509-0011 4.00 5.3 µM 4.50E-5 382 3.14E-5
20 SGTC_1169 aniline yellow 3.98 25.8 µM 4.88E-5 7 3.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 2.90E-10 YJL071W ARG2 hom Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p
0.108 4.22E-10 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.106 7.33E-10 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.103 2.58E-9 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.100 6.11E-9 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.098 1.13E-8 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.096 2.40E-8 YDR512C EMI1 hom Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs
0.095 4.18E-8 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.094 4.17E-8 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.093 6.41E-8 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.093 7.38E-8 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.093 7.77E-8 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.092 9.73E-8 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.091 1.44E-7 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.090 1.92E-7 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p