YOR150W / MRPL23

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR150W / MRPL23

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.46|P-value:5.04E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:4.99|P-value:1.34E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.01|P-value:8.52E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.45|P-value:6.44E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.97|P-value:2.24E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:9.83|P-value:5.46E-21 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.39|P-value:7.88E-10 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.78|P-value:1.08E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.57|P-value:4.24E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.47|P-value:3.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.51|P-value:1.05E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:6.76|P-value:8.11E-11 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:8.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.90|P-value:5.05E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.83|P-value:1.27E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:3.35|P-value:8.70E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:7.84|P-value:5.47E-14 ID:SGTC_653|Compound:0203-0016|FD-Score:7.25|P-value:3.42E-12 ID:SGTC_655|Compound:k060-0012|FD-Score:4.49|P-value:1.23E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:4.07|P-value:6.88E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.90|P-value:6.80E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.19|P-value:4.18E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:5.32|P-value:2.65E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.55|P-value:4.57E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.01|P-value:8.58E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.85|P-value:1.56E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.93|P-value:1.77E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:5.95|P-value:9.93E-9 ID:SGTC_950|Compound:1165-0508|FD-Score:4.35|P-value:2.23E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.42|P-value:3.99E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.55|P-value:9.49E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.70|P-value:2.64E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.62|P-value:3.54E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.80|P-value:9.83E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.45|P-value:6.44E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.51|P-value:5.27E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.46|P-value:6.16E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.15|P-value:4.88E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.71|P-value:2.60E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.36|P-value:8.61E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.40|P-value:7.60E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.39|P-value:1.83E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.40|P-value:4.29E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.79|P-value:1.94E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.00|P-value:5.60E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-3.18|P-value:8.94E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.47|P-value:1.36E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.56|P-value:9.14E-6 ID:SGTC_2028|Compound:5153890|FD-Score:3.86|P-value:1.49E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.57|P-value:4.22E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.68|P-value:2.89E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.04|P-value:7.51E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.76|P-value:2.13E-4 ID:SGTC_2241|Compound:6772625|FD-Score:5.14|P-value:6.60E-7 ID:SGTC_2276|Compound:7947513|FD-Score:3.89|P-value:1.35E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.44|P-value:6.61E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.95|P-value:5.59E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.97|P-value:1.00E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.74|P-value:4.16E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.20|P-value:8.23E-4 ID:SGTC_2551|Compound:apiole|FD-Score:4.88|P-value:2.22E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:5.27|P-value:3.36E-7 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.10|P-value:6.03E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.36|P-value:4.85E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.19|P-value:8.68E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.54|P-value:2.62E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.63|P-value:3.15E-6 ID:SGTC_2928|Compound:9011484|FD-Score:4.17|P-value:4.51E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.71|P-value:2.56E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.93|P-value:1.75E-6 ID:SGTC_3016|Compound:9080866|FD-Score:6.19|P-value:2.58E-9 ID:SGTC_3338|Compound:9144300|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.46|P-value:5.04E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:4.99|P-value:1.34E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.01|P-value:8.52E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.45|P-value:6.44E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.97|P-value:2.24E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:9.83|P-value:5.46E-21 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.39|P-value:7.88E-10 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.78|P-value:1.08E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.57|P-value:4.24E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.47|P-value:3.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.51|P-value:1.05E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:6.76|P-value:8.11E-11 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:8.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.90|P-value:5.05E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.83|P-value:1.27E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:3.35|P-value:8.70E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:7.84|P-value:5.47E-14 ID:SGTC_653|Compound:0203-0016|FD-Score:7.25|P-value:3.42E-12 ID:SGTC_655|Compound:k060-0012|FD-Score:4.49|P-value:1.23E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:4.07|P-value:6.88E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.90|P-value:6.80E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.19|P-value:4.18E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:5.32|P-value:2.65E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.55|P-value:4.57E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.01|P-value:8.58E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.85|P-value:1.56E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.93|P-value:1.77E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:5.95|P-value:9.93E-9 ID:SGTC_950|Compound:1165-0508|FD-Score:4.35|P-value:2.23E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.42|P-value:3.99E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.55|P-value:9.49E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.70|P-value:2.64E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.62|P-value:3.54E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.80|P-value:9.83E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.45|P-value:6.44E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.51|P-value:5.27E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.46|P-value:6.16E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.15|P-value:4.88E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.71|P-value:2.60E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.36|P-value:8.61E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.40|P-value:7.60E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.39|P-value:1.83E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.40|P-value:4.29E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.79|P-value:1.94E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.00|P-value:5.60E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-3.18|P-value:8.94E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.47|P-value:1.36E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.56|P-value:9.14E-6 ID:SGTC_2028|Compound:5153890|FD-Score:3.86|P-value:1.49E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.57|P-value:4.22E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.68|P-value:2.89E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.04|P-value:7.51E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.76|P-value:2.13E-4 ID:SGTC_2241|Compound:6772625|FD-Score:5.14|P-value:6.60E-7 ID:SGTC_2276|Compound:7947513|FD-Score:3.89|P-value:1.35E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.44|P-value:6.61E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.95|P-value:5.59E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.97|P-value:1.00E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.74|P-value:4.16E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-3.20|P-value:8.23E-4 ID:SGTC_2551|Compound:apiole|FD-Score:4.88|P-value:2.22E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:5.27|P-value:3.36E-7 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.10|P-value:6.03E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.36|P-value:4.85E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.19|P-value:8.68E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.54|P-value:2.62E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.63|P-value:3.15E-6 ID:SGTC_2928|Compound:9011484|FD-Score:4.17|P-value:4.51E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.71|P-value:2.56E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.93|P-value:1.75E-6 ID:SGTC_3016|Compound:9080866|FD-Score:6.19|P-value:2.58E-9 ID:SGTC_3338|Compound:9144300|FD-Score:3.72|P-value:2.46E-4

Top fitness defect scores for YOR150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.83 5.3 µM 5.46E-21 198 4.37E-23
2 SGTC_173 1273-0061 7.97 2.7 µM 2.24E-14 mitochondrial stress 67 8.22E-16
3 SGTC_650 1328-0195 7.84 38.0 µM 5.47E-14 3 2.19E-15
4 SGTC_653 0203-0016 7.25 55.2 µM 3.42E-12 2 2.09E-13
5 SGTC_386 1509-0011 6.76 3.1 µM 8.11E-11 82 6.82E-12
6 SGTC_10 0279-0212 6.46 42.6 µM 5.04E-10 TRP & mitochondrial translation 23 5.11E-11
7 SGTC_275 trichlorophene 6.39 5.7 µM 7.88E-10 mitochondrial stress 104 8.36E-11
8 SGTC_3016 9080866 6.19 49.5 µM 2.58E-9 3 3.09E-10
9 SGTC_908 3448-7491 5.95 47.7 µM 9.93E-9 mitochondrial stress 51 1.37E-9
10 SGTC_310 1273-0058 5.51 1.1 µM 1.05E-7 mitochondrial stress 162 1.84E-8
11 SGTC_777 1315-0167 5.32 517.0 µM 2.65E-7 Golgi 13 5.13E-8
12 SGTC_2552 juarezic acid 5.27 87.0 µM 3.36E-7 TSC3-RPN4 9 6.65E-8
13 SGTC_2241 6772625 5.14 37.8 µM 6.60E-7 9 1.40E-7
14 SGTC_58 0957-0393 4.99 9.0 µM 1.34E-6 cell wall 285 3.08E-7
15 SGTC_2954 9074818 4.93 52.7 µM 1.75E-6 20 4.11E-7
16 SGTC_853 0419-0306 4.93 21.0 µM 1.77E-6 5 4.17E-7
17 SGTC_2551 apiole 4.88 73.9 µM 2.22E-6 4 5.37E-7
18 SGTC_2455 5377712 4.74 9.8 µM 4.16E-6 12 1.07E-6
19 SGTC_1970 st070122 4.56 35.8 µM 9.14E-6 TSC3-RPN4 18 2.56E-6
20 SGTC_995 3931-2021 4.55 34.6 µM 9.49E-6 RPP1 & pyrimidine depletion 12 2.67E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.385 5.39E-119 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.383 5.51E-118 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.367 9.11E-108 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.366 6.68E-107 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.352 1.58E-98 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.350 2.48E-97 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.349 9.42E-97 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.341 9.66E-92 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.338 1.20E-90 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.335 1.21E-88 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.334 3.07E-88 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.333 1.21E-87 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.333 1.47E-87 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.322 6.92E-82 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.322 2.23E-81 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport