YOR151C / RPB2

RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR151C / RPB2

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.39|P-value:8.96E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.71|P-value:3.20E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:5.27|P-value:6.07E-7 ID:SGTC_589|Compound:1227-0070|FD-Score:3.53|P-value:5.70E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.45|P-value:7.43E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.40|P-value:8.59E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.71|P-value:3.50E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.66|P-value:3.72E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.80|P-value:2.29E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.63|P-value:4.16E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.85|P-value:2.16E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.33|P-value:4.71E-7 ID:SGTC_2001|Compound:4023502|FD-Score:3.53|P-value:5.74E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.95|P-value:1.39E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.18|P-value:5.89E-5 ID:SGTC_2163|Compound:5671233|FD-Score:5.22|P-value:7.89E-7 ID:SGTC_2439|Compound:5492030|FD-Score:-3.93|P-value:1.67E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.57E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.81|P-value:2.53E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.41|P-value:2.81E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.02|P-value:1.05E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.43|P-value:8.67E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.48|P-value:7.51E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.67|P-value:3.63E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.46|P-value:7.85E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.39|P-value:8.96E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.71|P-value:3.20E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:5.27|P-value:6.07E-7 ID:SGTC_589|Compound:1227-0070|FD-Score:3.53|P-value:5.70E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.45|P-value:7.43E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.40|P-value:8.59E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.71|P-value:3.50E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.66|P-value:3.72E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.80|P-value:2.29E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.63|P-value:4.16E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.85|P-value:2.16E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.33|P-value:4.71E-7 ID:SGTC_2001|Compound:4023502|FD-Score:3.53|P-value:5.74E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.95|P-value:1.39E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.18|P-value:5.89E-5 ID:SGTC_2163|Compound:5671233|FD-Score:5.22|P-value:7.89E-7 ID:SGTC_2439|Compound:5492030|FD-Score:-3.93|P-value:1.67E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.57E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.81|P-value:2.53E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.41|P-value:2.81E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.02|P-value:1.05E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.43|P-value:8.67E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.48|P-value:7.51E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.67|P-value:3.63E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.46|P-value:7.85E-4

Top fitness defect scores for YOR151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1723 st034307 5.33 2.5 µM 4.71E-7 mitochondrial processes 8 4.96E-8 0.28
2 SGTC_526 4469-0568 5.27 170.0 µM 6.07E-7 azole & statin 4 6.68E-8 0.23
3 SGTC_2163 5671233 5.22 125.0 µM 7.89E-7 7 9.08E-8 0.45
4 SGTC_2111 5486399 4.18 200.0 µM 5.89E-5 21 1.45E-5 0.10
5 SGTC_2969 9091408 4.02 28.7 µM 1.05E-4 5 2.86E-5 0.09
6 SGTC_2109 5483026 3.95 200.0 µM 1.39E-4 RSC complex & mRNA processing 36 3.97E-5 0.25
7 SGTC_1308 1187-1617 3.80 41.4 µM 2.29E-4 fatty acid desaturase (OLE1) 11 7.14E-5 0.08
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.77 3.7 µM 2.57E-4 15 8.17E-5 0.12
9 SGTC_121 0557-0495 3.71 61.3 µM 3.20E-4 calcium & mitochondrial duress 8 1.06E-4 0.05
10 SGTC_3000 9075062 3.67 71.4 µM 3.63E-4 10 1.22E-4 0.41
11 SGTC_1133 3473-0247 3.66 50.0 µM 3.72E-4 RSC complex & mRNA processing 56 1.26E-4 0.10
12 SGTC_1493 4348-0038 3.63 111.0 µM 4.16E-4 RSC complex & mRNA processing 41 1.43E-4 0.10
13 SGTC_589 1227-0070 3.53 34.1 µM 5.70E-4 17 2.08E-4 0.13
14 SGTC_2001 4023502 3.53 57.7 µM 5.74E-4 mitochondrial processes 9 2.09E-4 0.16
15 SGTC_624 k048-0052 3.45 28.0 µM 7.43E-4 Golgi 12 2.83E-4 0.23
16 SGTC_682 0kpi-0099 3.40 17.0 µM 8.59E-4 42 3.36E-4 0.00
17 SGTC_77 0828-0286 3.39 12.5 µM 8.96E-4 TSC3-RPN4 10 3.53E-4 0.06
18 SGTC_1213 1315-0166 3.22 115.0 µM 0.00150 27 6.46E-4 0.03
19 SGTC_1674 st016616 3.17 23.6 µM 0.00172 17 7.53E-4 0.09
20 SGTC_1374 2889-5571 3.13 141.0 µM 0.00197 RSC complex & mRNA processing 54 8.87E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.05E-20 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.148 5.73E-18 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.141 1.95E-16 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.134 6.05E-15 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.130 3.78E-14 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.129 6.65E-14 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.128 1.07E-13 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.113 6.57E-11 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.112 9.14E-11 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.109 2.69E-10 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.109 2.66E-10 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.108 3.35E-10 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.107 5.10E-10 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.106 8.14E-10 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.105 9.22E-10 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor