YOR156C / NFI1

SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR156C / NFI1

Click on Significant Values for Screen Details ID:SGTC_154|Compound:3389-1638|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.77|P-value:5.30E-7 ID:SGTC_618|Compound:k072-0232|FD-Score:3.80|P-value:4.98E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:5.02|P-value:1.36E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.61|P-value:1.11E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-5.63|P-value:3.69E-9 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.53|P-value:7.12E-9 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.55|P-value:1.36E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.38|P-value:3.55E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:5.85|P-value:1.03E-9 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.27|P-value:3.86E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.81|P-value:4.55E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.23|P-value:4.66E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.47|P-value:2.37E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.54|P-value:1.44E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.65|P-value:9.47E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.25|P-value:4.33E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.44|P-value:2.69E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.88|P-value:3.58E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.50|P-value:1.69E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.06|P-value:8.65E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.65|P-value:9.75E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.58|P-value:1.22E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:7.70|P-value:1.49E-15 ID:SGTC_1578|Compound:josamycin|FD-Score:3.09|P-value:7.82E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.04|P-value:9.28E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.13|P-value:6.47E-4 ID:SGTC_1707|Compound:st032323|FD-Score:8.29|P-value:1.03E-17 ID:SGTC_1757|Compound:st041620|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.24|P-value:4.51E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.24|P-value:4.55E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.04|P-value:9.22E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.15|P-value:1.05E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.64|P-value:9.67E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.11|P-value:1.31E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.37|P-value:2.84E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.34|P-value:4.46E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-4.21|P-value:7.89E-6 ID:SGTC_2436|Compound:5633522|FD-Score:-4.42|P-value:2.88E-6 ID:SGTC_2448|Compound:5185112|FD-Score:-3.97|P-value:2.27E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.41|P-value:1.54E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.19|P-value:5.41E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.07|P-value:8.39E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.48|P-value:1.75E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_3050|Compound:9093513|FD-Score:5.50|P-value:8.66E-9 ID:SGTC_3238|Compound:9133470|FD-Score:-3.58|P-value:1.19E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.77|P-value:5.30E-7 ID:SGTC_618|Compound:k072-0232|FD-Score:3.80|P-value:4.98E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:5.02|P-value:1.36E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.61|P-value:1.11E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-5.63|P-value:3.69E-9 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.53|P-value:7.12E-9 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.55|P-value:1.36E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.38|P-value:3.55E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:5.85|P-value:1.03E-9 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.27|P-value:3.86E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.81|P-value:4.55E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.23|P-value:4.66E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.47|P-value:2.37E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.54|P-value:1.44E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.65|P-value:9.47E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.25|P-value:4.33E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.44|P-value:2.69E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.88|P-value:3.58E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.50|P-value:1.69E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.06|P-value:8.65E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.65|P-value:9.75E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.58|P-value:1.22E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:7.70|P-value:1.49E-15 ID:SGTC_1578|Compound:josamycin|FD-Score:3.09|P-value:7.82E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.04|P-value:9.28E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.13|P-value:6.47E-4 ID:SGTC_1707|Compound:st032323|FD-Score:8.29|P-value:1.03E-17 ID:SGTC_1757|Compound:st041620|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.24|P-value:4.51E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.24|P-value:4.55E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.04|P-value:9.22E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.58|P-value:1.24E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.15|P-value:1.05E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.64|P-value:9.67E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.11|P-value:1.31E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.37|P-value:2.84E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.34|P-value:4.46E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-4.21|P-value:7.89E-6 ID:SGTC_2436|Compound:5633522|FD-Score:-4.42|P-value:2.88E-6 ID:SGTC_2448|Compound:5185112|FD-Score:-3.97|P-value:2.27E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.41|P-value:1.54E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.19|P-value:5.41E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.07|P-value:8.39E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.48|P-value:1.75E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_3050|Compound:9093513|FD-Score:5.50|P-value:8.66E-9 ID:SGTC_3238|Compound:9133470|FD-Score:-3.58|P-value:1.19E-4

Top fitness defect scores for YOR156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1707 st032323 8.29 6.3 µM 1.03E-17 DNA damage response 14 5.86E-17
2 SGTC_1576 erythromycin ethylsuccinate 7.70 23.2 µM 1.49E-15 2 6.67E-15
3 SGTC_727 3032-0951 5.85 202.0 µM 1.03E-9 7 2.45E-9
4 SGTC_3050 9093513 5.50 49.5 µM 8.66E-9 5 1.87E-8
5 SGTC_2687 chenodiol 5.41 100.0 µM 1.54E-8 4 3.23E-8
6 SGTC_673 1082-0474 5.02 110.0 µM 1.36E-7 RSC complex & mRNA processing 36 2.59E-7
7 SGTC_517 1365-0151 4.77 113.0 µM 5.30E-7 21 9.44E-7
8 SGTC_1043 0916-0009 4.65 19.3 µM 9.47E-7 12 1.64E-6
9 SGTC_1565 sinapyl alcohol 4.65 95.1 µM 9.75E-7 12 1.69E-6
10 SGTC_1027 k015-0025 4.47 8.7 µM 2.37E-6 18 3.95E-6
11 SGTC_1053 3366-3204 4.44 134.0 µM 2.69E-6 cell wall 24 4.44E-6
12 SGTC_2401 5128683 4.34 200.0 µM 4.46E-6 30 7.21E-6
13 SGTC_2259 7964009 4.15 200.0 µM 1.05E-5 superoxide 25 1.63E-5
14 SGTC_2396 5342950 4.11 42.8 µM 1.31E-5 RSC complex & mRNA processing 38 2.02E-5
15 SGTC_1359 1582-0056 3.88 520.0 nM 3.58E-5 21 5.26E-5
16 SGTC_618 k072-0232 3.80 33.2 µM 4.98E-5 60S ribosome export 8 7.21E-5
17 SGTC_2389 9091542 3.64 195.5 µM 9.67E-5 iron homeostasis 46 1.36E-4
18 SGTC_682 0kpi-0099 3.61 17.0 µM 1.11E-4 84 1.55E-4
19 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.58 85.4 µM 1.22E-4 34 1.70E-4
20 SGTC_2059 5238311 3.58 157.0 µM 1.24E-4 36 1.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.36E-16 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.138 1.15E-15 YPL174C NIP100 hom Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
0.111 1.17E-10 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.111 1.37E-10 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.109 2.23E-10 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.107 4.54E-10 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.101 5.17E-9 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.096 2.31E-8 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.096 2.57E-8 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.094 5.55E-8 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
0.093 6.26E-8 YGL121C GPG1 hom Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing
0.091 1.17E-7 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.089 2.48E-7 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.087 3.89E-7 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.086 5.75E-7 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions