YOR158W / PET123

Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR158W / PET123

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.15|P-value:4.19E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.35|P-value:6.81E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.67|P-value:2.84E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:8.25|P-value:1.41E-15 ID:SGTC_70|Compound:0141-0289|FD-Score:8.11|P-value:4.18E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:6.21|P-value:1.42E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.77|P-value:1.72E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:10.10|P-value:2.36E-22 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.46|P-value:8.60E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:5.17|P-value:3.70E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:3.27|P-value:8.77E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.79|P-value:1.46E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:5.08|P-value:5.89E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:17.10|P-value:8.07E-61 ID:SGTC_201|Compound:4262-0159|FD-Score:4.28|P-value:2.16E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:4.14|P-value:3.69E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.39|P-value:5.63E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.39|P-value:1.34E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.50|P-value:5.43E-86 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.69|P-value:8.61E-21 ID:SGTC_279|Compound:1273-0055|FD-Score:4.65|P-value:4.30E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:4.50|P-value:8.30E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.21|P-value:3.16E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.33|P-value:1.58E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:5.19|P-value:3.36E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:14.90|P-value:2.31E-46 ID:SGTC_431|Compound:k089-0097|FD-Score:-8.08|P-value:4.20E-15 ID:SGTC_444|Compound:curcumin|FD-Score:-6.30|P-value:7.02E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.34|P-value:5.91E-16 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.69|P-value:6.72E-11 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.95|P-value:1.39E-11 ID:SGTC_502|Compound:l-744,832|FD-Score:3.91|P-value:9.30E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.17|P-value:3.32E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:4.18|P-value:3.23E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.71|P-value:1.93E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.59|P-value:1.37E-10 ID:SGTC_700|Compound:3453-2283|FD-Score:5.24|P-value:2.71E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:3.49|P-value:4.28E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.26|P-value:8.49E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-4.13|P-value:3.57E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.47|P-value:4.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.46|P-value:4.65E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.91|P-value:9.25E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.80|P-value:2.01E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.68|P-value:3.74E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.81|P-value:1.25E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.15|P-value:3.58E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.64|P-value:2.51E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.61|P-value:2.59E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.82|P-value:1.31E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.77|P-value:1.56E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.19|P-value:3.03E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.69|P-value:4.16E-17 ID:SGTC_1605|Compound:st000082|FD-Score:-3.24|P-value:9.08E-4 ID:SGTC_1621|Compound:st003705|FD-Score:5.18|P-value:3.54E-7 ID:SGTC_1622|Compound:st003707|FD-Score:3.50|P-value:4.12E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.70|P-value:3.49E-6 ID:SGTC_1635|Compound:st007035|FD-Score:18.70|P-value:6.67E-72 ID:SGTC_1658|Compound:st012944|FD-Score:-4.44|P-value:9.73E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.39|P-value:1.10E-7 ID:SGTC_1742|Compound:st038235|FD-Score:5.46|P-value:8.55E-8 ID:SGTC_1771|Compound:st048882|FD-Score:4.12|P-value:4.00E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.37|P-value:7.39E-13 ID:SGTC_1849|Compound:st056239|FD-Score:3.44|P-value:5.04E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.25|P-value:2.42E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.99|P-value:6.91E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.96|P-value:5.87E-9 ID:SGTC_1985|Compound:st071382|FD-Score:4.02|P-value:6.09E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_2072|Compound:5231554|FD-Score:4.78|P-value:2.45E-6 ID:SGTC_2080|Compound:5212524|FD-Score:-3.92|P-value:8.17E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.63|P-value:2.60E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.39|P-value:6.05E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.54|P-value:3.57E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.32|P-value:1.67E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.64|P-value:1.28E-13 ID:SGTC_2285|Compound:7945142|FD-Score:3.57|P-value:3.18E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.38|P-value:1.38E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.47|P-value:4.52E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.46|P-value:4.64E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.31|P-value:1.33E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:6.98|P-value:1.15E-11 ID:SGTC_2586|Compound:curcumin|FD-Score:-5.33|P-value:1.50E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.38|P-value:5.68E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.65|P-value:2.40E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.34|P-value:7.12E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.35|P-value:6.45E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.98|P-value:7.04E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.73|P-value:1.70E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.38|P-value:5.75E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.41|P-value:5.54E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.12|P-value:3.77E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-3.32|P-value:6.94E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.85|P-value:1.05E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.07|P-value:4.97E-5 ID:SGTC_3202|Compound:9113761|FD-Score:5.01|P-value:8.38E-7 ID:SGTC_3207|Compound:9114163|FD-Score:-4.19|P-value:2.77E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-4.87|P-value:1.46E-6 ID:SGTC_3355|Compound:9151058|FD-Score:3.35|P-value:6.90E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.15|P-value:4.19E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.35|P-value:6.81E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.67|P-value:2.84E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:8.25|P-value:1.41E-15 ID:SGTC_70|Compound:0141-0289|FD-Score:8.11|P-value:4.18E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:6.21|P-value:1.42E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.77|P-value:1.72E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:10.10|P-value:2.36E-22 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.46|P-value:8.60E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:5.17|P-value:3.70E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:3.27|P-value:8.77E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.79|P-value:1.46E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:5.08|P-value:5.89E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:17.10|P-value:8.07E-61 ID:SGTC_201|Compound:4262-0159|FD-Score:4.28|P-value:2.16E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:4.14|P-value:3.69E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.39|P-value:5.63E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.39|P-value:1.34E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.50|P-value:5.43E-86 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.69|P-value:8.61E-21 ID:SGTC_279|Compound:1273-0055|FD-Score:4.65|P-value:4.30E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:4.50|P-value:8.30E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.21|P-value:3.16E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.33|P-value:1.58E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:5.19|P-value:3.36E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:14.90|P-value:2.31E-46 ID:SGTC_431|Compound:k089-0097|FD-Score:-8.08|P-value:4.20E-15 ID:SGTC_444|Compound:curcumin|FD-Score:-6.30|P-value:7.02E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.34|P-value:5.91E-16 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.69|P-value:6.72E-11 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.95|P-value:1.39E-11 ID:SGTC_502|Compound:l-744,832|FD-Score:3.91|P-value:9.30E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.17|P-value:3.32E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:4.18|P-value:3.23E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.71|P-value:1.93E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.59|P-value:1.37E-10 ID:SGTC_700|Compound:3453-2283|FD-Score:5.24|P-value:2.71E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:3.49|P-value:4.28E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.26|P-value:8.49E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-4.13|P-value:3.57E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:3.47|P-value:4.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.46|P-value:4.65E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.91|P-value:9.25E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.80|P-value:2.01E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.68|P-value:3.74E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.81|P-value:1.25E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.15|P-value:3.58E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.64|P-value:2.51E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.61|P-value:2.59E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.82|P-value:1.31E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.47|P-value:4.55E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.77|P-value:1.56E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.19|P-value:3.03E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.69|P-value:4.16E-17 ID:SGTC_1605|Compound:st000082|FD-Score:-3.24|P-value:9.08E-4 ID:SGTC_1621|Compound:st003705|FD-Score:5.18|P-value:3.54E-7 ID:SGTC_1622|Compound:st003707|FD-Score:3.50|P-value:4.12E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.70|P-value:3.49E-6 ID:SGTC_1635|Compound:st007035|FD-Score:18.70|P-value:6.67E-72 ID:SGTC_1658|Compound:st012944|FD-Score:-4.44|P-value:9.73E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.39|P-value:1.10E-7 ID:SGTC_1742|Compound:st038235|FD-Score:5.46|P-value:8.55E-8 ID:SGTC_1771|Compound:st048882|FD-Score:4.12|P-value:4.00E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.37|P-value:7.39E-13 ID:SGTC_1849|Compound:st056239|FD-Score:3.44|P-value:5.04E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.25|P-value:2.42E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.99|P-value:6.91E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.96|P-value:5.87E-9 ID:SGTC_1985|Compound:st071382|FD-Score:4.02|P-value:6.09E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_2072|Compound:5231554|FD-Score:4.78|P-value:2.45E-6 ID:SGTC_2080|Compound:5212524|FD-Score:-3.92|P-value:8.17E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.63|P-value:2.60E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.39|P-value:6.05E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.54|P-value:3.57E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.32|P-value:1.67E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.64|P-value:1.28E-13 ID:SGTC_2285|Compound:7945142|FD-Score:3.57|P-value:3.18E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.38|P-value:1.38E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.47|P-value:4.52E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.46|P-value:4.64E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.31|P-value:1.33E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:6.98|P-value:1.15E-11 ID:SGTC_2586|Compound:curcumin|FD-Score:-5.33|P-value:1.50E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.38|P-value:5.68E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.65|P-value:2.40E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.34|P-value:7.12E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.35|P-value:6.45E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.98|P-value:7.04E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.73|P-value:1.70E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.38|P-value:5.75E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.41|P-value:5.54E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.12|P-value:3.77E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-3.32|P-value:6.94E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.85|P-value:1.05E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.07|P-value:4.97E-5 ID:SGTC_3202|Compound:9113761|FD-Score:5.01|P-value:8.38E-7 ID:SGTC_3207|Compound:9114163|FD-Score:-4.19|P-value:2.77E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-4.87|P-value:1.46E-6 ID:SGTC_3355|Compound:9151058|FD-Score:3.35|P-value:6.90E-4

Top fitness defect scores for YOR158W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.50 5.3 µM 5.43E-86 50 1.98E-93
2 SGTC_1635 st007035 18.70 42.4 µM 6.67E-72 23 4.22E-78
3 SGTC_173 1273-0061 17.10 2.7 µM 8.07E-61 mitochondrial stress 4 4.82E-66
4 SGTC_386 1509-0011 14.90 3.1 µM 2.31E-46 21 2.58E-50
5 SGTC_119 0121-0043 10.10 24.8 µM 2.36E-22 mitochondrial stress 5 3.41E-24
6 SGTC_275 trichlorophene 9.69 5.7 µM 8.61E-21 mitochondrial stress 49 1.71E-22
7 SGTC_1597 7-benzyloxygramine 8.69 47.5 µM 4.16E-17 calcium & mitochondrial duress 21 1.74E-18
8 SGTC_64 000l-0018 8.25 272.1 µM 1.41E-15 ubiquinone biosynthesis & proteasome 47 8.03E-17
9 SGTC_70 0141-0289 8.11 43.3 µM 4.18E-15 mitochondrial stress 39 2.62E-16
10 SGTC_2250 alverine citrate 7.64 130.0 µM 1.28E-13 24 1.09E-14
11 SGTC_2582 agaric acid 7.31 100.0 µM 1.33E-12 redox potentiating 119 1.38E-13
12 SGTC_2584 androsterone 6.98 48.7 µM 1.15E-11 cell wall 40 1.44E-12
13 SGTC_467 ro 31-8220 6.95 72.8 µM 1.39E-11 calcium & mitochondrial duress 24 1.77E-12
14 SGTC_690 glyoxal 6.59 20.3 µM 1.37E-10 36 2.13E-11
15 SGTC_86 0417-1630 6.21 471.9 µM 1.42E-9 ubiquinone biosynthesis & proteasome 86 2.71E-10
16 SGTC_1883 5-benzylidenerhodanine 5.96 20.0 µM 5.87E-9 TRP & mitochondrial translation 20 1.27E-9
17 SGTC_134 0269-0018 5.79 6.9 µM 1.46E-8 85 3.42E-9
18 SGTC_116 0155-0182 5.77 31.8 µM 1.72E-8 mitochondrial response to ROS 28 4.08E-9
19 SGTC_36 0335-0881 5.67 14.2 µM 2.84E-8 ubiquinone biosynthesis & proteasome 71 7.05E-9
20 SGTC_1742 st038235 5.46 28.9 µM 8.55E-8 mitochondrial stress 62 2.33E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.557 6.82E-273 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.554 1.88E-268 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.549 4.05E-263 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.528 1.59E-240 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.520 8.25E-232 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.519 4.90E-231 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.519 2.06E-230 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.516 3.91E-228 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.515 3.52E-227 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.513 1.95E-224 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.511 1.93E-222 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.498 6.09E-210 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.495 6.03E-207 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.492 4.29E-204 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.491 2.80E-203 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport