YOR159C / SME1

Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR159C / SME1

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:2.69|P-value:9.56E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.62|P-value:4.01E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.17|P-value:7.54E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.95|P-value:1.44E-25 ID:SGTC_155|Compound:k072-0202|FD-Score:3.25|P-value:8.88E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.77|P-value:6.65E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.99|P-value:2.46E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:3.09|P-value:1.86E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:2.73|P-value:8.13E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.87|P-value:4.63E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:2.71|P-value:8.85E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.81|P-value:5.32E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.06|P-value:1.19E-16 ID:SGTC_910|Compound:3454-3003|FD-Score:3.37|P-value:5.14E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.35|P-value:5.64E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.16|P-value:6.37E-7 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.74|P-value:7.94E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.85|P-value:4.50E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.06|P-value:2.13E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.86|P-value:4.11E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.76|P-value:7.39E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-2.76|P-value:6.44E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.02|P-value:2.15E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.22|P-value:4.47E-7 ID:SGTC_2003|Compound:4023581|FD-Score:-2.74|P-value:6.89E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.51|P-value:9.73E-8 ID:SGTC_2320|Compound:7373003|FD-Score:-3.15|P-value:1.22E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.72|P-value:2.57E-8 ID:SGTC_2363|Compound:9053361|FD-Score:4.33|P-value:2.93E-7 ID:SGTC_2475|Compound:5812728|FD-Score:2.76|P-value:7.23E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.51|P-value:2.53E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-2.79|P-value:5.75E-4 ID:SGTC_3039|Compound:9090270|FD-Score:2.79|P-value:6.46E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.70|P-value:2.78E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-3.17|P-value:1.11E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.13|P-value:1.51E-4 ID:SGTC_3204|Compound:9114183|FD-Score:2.95|P-value:3.39E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:2.69|P-value:9.56E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.62|P-value:4.01E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.17|P-value:7.54E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.95|P-value:1.44E-25 ID:SGTC_155|Compound:k072-0202|FD-Score:3.25|P-value:8.88E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.77|P-value:6.65E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.99|P-value:2.46E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:3.09|P-value:1.86E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:2.73|P-value:8.13E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.87|P-value:4.63E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:2.71|P-value:8.85E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.81|P-value:5.32E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.06|P-value:1.19E-16 ID:SGTC_910|Compound:3454-3003|FD-Score:3.37|P-value:5.14E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.35|P-value:5.64E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.16|P-value:6.37E-7 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.74|P-value:7.94E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.85|P-value:4.50E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.06|P-value:2.13E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.86|P-value:4.11E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.76|P-value:7.39E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-2.76|P-value:6.44E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.02|P-value:2.15E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.22|P-value:4.47E-7 ID:SGTC_2003|Compound:4023581|FD-Score:-2.74|P-value:6.89E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.51|P-value:9.73E-8 ID:SGTC_2320|Compound:7373003|FD-Score:-3.15|P-value:1.22E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.72|P-value:2.57E-8 ID:SGTC_2363|Compound:9053361|FD-Score:4.33|P-value:2.93E-7 ID:SGTC_2475|Compound:5812728|FD-Score:2.76|P-value:7.23E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.51|P-value:2.53E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-2.79|P-value:5.75E-4 ID:SGTC_3039|Compound:9090270|FD-Score:2.79|P-value:6.46E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.70|P-value:2.78E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-3.17|P-value:1.11E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.13|P-value:1.51E-4 ID:SGTC_3204|Compound:9114183|FD-Score:2.95|P-value:3.39E-4

Top fitness defect scores for YOR159C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2344 7990960 4.72 77.0 µM 2.57E-8 28 1.20E-6 0.06
2 SGTC_3044 9093193 4.70 49.5 µM 2.78E-8 1 1.28E-6 0.46
3 SGTC_2312 7706453 4.51 155.7 µM 9.73E-8 4 3.29E-6 0.15
4 SGTC_2363 9053361 4.33 176.0 µM 2.93E-7 Golgi 9 7.56E-6 0.17
5 SGTC_124 0136-0217 4.17 7.1 µM 7.54E-7 mitochondrial stress 22 1.54E-5 0.15
6 SGTC_1421 4029-0249 3.86 71.4 µM 4.11E-6 3 5.58E-5 0.11
7 SGTC_333 3486-0131 3.77 40.1 µM 6.65E-6 amide catabolism 2 8.04E-5 0.15
8 SGTC_3002 9075603 3.51 71.4 µM 2.53E-5 10 2.21E-4 0.01
9 SGTC_910 3454-3003 3.37 490.0 µM 5.14E-5 7 3.79E-4 0.06
10 SGTC_1069 diphenylcyclopropenone 3.35 8.5 µM 5.64E-5 14 4.07E-4 0.03
11 SGTC_155 k072-0202 3.25 43.6 µM 8.88E-5 14 5.75E-4 0.17
12 SGTC_3155 9099265 3.13 49.5 µM 1.51E-4 19 8.62E-4 0.07
13 SGTC_487 nimodipine 3.09 119.0 µM 1.86E-4 2 0.00101 0.06
14 SGTC_1418 3966-3099 3.06 2.4 µM 2.13E-4 14 0.00112 0.05
15 SGTC_3204 9114183 2.95 49.5 µM 3.39E-4 20 0.00160 0.05
16 SGTC_650 1328-0195 2.87 38.0 µM 4.63E-4 14 0.00203 0.02
17 SGTC_3039 9090270 2.79 49.5 µM 6.46E-4 RPP1 & pyrimidine depletion 10 0.00261 0.17
18 SGTC_2475 5812728 2.76 15.0 µM 7.23E-4 mitochondrial processes 32 0.00285 0.01
19 SGTC_1454 4239-0054 2.76 42.6 µM 7.39E-4 16 0.00290 0.04
20 SGTC_1198 1612-1005 2.74 86.7 µM 7.94E-4 18 0.00306 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 1.14E-57 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.269 1.13E-56 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.238 2.03E-44 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.237 3.69E-44 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.232 2.44E-42 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
0.232 3.47E-42 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.225 8.85E-40 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.222 9.58E-39 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.212 1.95E-35 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.208 4.95E-34 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.197 1.21E-30 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.183 1.23E-26 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.182 1.84E-26 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.178 2.80E-25 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.177 5.95E-25 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2