YOR160W / MTR10

Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR160W / MTR10

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.26|P-value:4.23E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.04|P-value:9.56E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.79|P-value:4.96E-7 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.03|P-value:9.79E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.03|P-value:9.60E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.23|P-value:4.82E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.61|P-value:1.12E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.80|P-value:4.54E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:-4.40|P-value:3.42E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.07|P-value:8.34E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.31|P-value:3.55E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.58|P-value:5.97E-9 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.16|P-value:6.08E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.77|P-value:5.80E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.97|P-value:2.46E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.72|P-value:6.87E-7 ID:SGTC_1207|Compound:2099-0101|FD-Score:6.23|P-value:9.21E-11 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.16|P-value:1.05E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.32|P-value:3.45E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.21|P-value:5.08E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.14|P-value:6.55E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.32|P-value:3.40E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.30|P-value:3.70E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.09|P-value:7.93E-4 ID:SGTC_1751|Compound:st044839|FD-Score:-3.03|P-value:9.64E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.68|P-value:8.30E-5 ID:SGTC_2225|Compound:6654152|FD-Score:3.51|P-value:1.65E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.23|P-value:4.73E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.18|P-value:5.83E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.27|P-value:4.07E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.06|P-value:1.62E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.30|P-value:3.74E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.54|P-value:1.73E-6 ID:SGTC_2351|Compound:9026858|FD-Score:5.25|P-value:3.96E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.70|P-value:7.86E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.69|P-value:7.95E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-4.40|P-value:3.36E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.12|P-value:7.02E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.85|P-value:4.10E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.11|P-value:7.47E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.05|P-value:9.19E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.19|P-value:5.60E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.08|P-value:8.32E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.89|P-value:3.43E-5 ID:SGTC_3019|Compound:9081971|FD-Score:4.57|P-value:1.47E-6 ID:SGTC_3189|Compound:9110682|FD-Score:3.80|P-value:5.06E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.16|P-value:6.07E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.24|P-value:4.59E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.22|P-value:4.97E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.20|P-value:5.42E-4 ID:SGTC_3341|Compound:9147222|FD-Score:7.19|P-value:9.60E-14 ID:SGTC_3347|Compound:9188721|FD-Score:4.53|P-value:1.84E-6 ID:SGTC_12|Compound:0849-0099|FD-Score:3.26|P-value:4.23E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.04|P-value:9.56E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.79|P-value:4.96E-7 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.03|P-value:9.79E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.03|P-value:9.60E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.23|P-value:4.82E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.61|P-value:1.12E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.80|P-value:4.54E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:-4.40|P-value:3.42E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.07|P-value:8.34E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.50|P-value:1.70E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.31|P-value:3.55E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.58|P-value:5.97E-9 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.16|P-value:6.08E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.77|P-value:5.80E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.97|P-value:2.46E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.72|P-value:6.87E-7 ID:SGTC_1207|Compound:2099-0101|FD-Score:6.23|P-value:9.21E-11 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.16|P-value:1.05E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.32|P-value:3.45E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.21|P-value:5.08E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.14|P-value:6.55E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.32|P-value:3.40E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.30|P-value:3.70E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.09|P-value:7.93E-4 ID:SGTC_1751|Compound:st044839|FD-Score:-3.03|P-value:9.64E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.68|P-value:8.30E-5 ID:SGTC_2225|Compound:6654152|FD-Score:3.51|P-value:1.65E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.23|P-value:4.73E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.18|P-value:5.83E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.27|P-value:4.07E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.06|P-value:1.62E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.30|P-value:3.74E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.54|P-value:1.73E-6 ID:SGTC_2351|Compound:9026858|FD-Score:5.25|P-value:3.96E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.70|P-value:7.86E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.69|P-value:7.95E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-4.40|P-value:3.36E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.12|P-value:7.02E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.85|P-value:4.10E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.11|P-value:7.47E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.05|P-value:9.19E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.19|P-value:5.60E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.08|P-value:8.32E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.89|P-value:3.43E-5 ID:SGTC_3019|Compound:9081971|FD-Score:4.57|P-value:1.47E-6 ID:SGTC_3189|Compound:9110682|FD-Score:3.80|P-value:5.06E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.16|P-value:6.07E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.24|P-value:4.59E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.22|P-value:4.97E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.20|P-value:5.42E-4 ID:SGTC_3341|Compound:9147222|FD-Score:7.19|P-value:9.60E-14 ID:SGTC_3347|Compound:9188721|FD-Score:4.53|P-value:1.84E-6

Top fitness defect scores for YOR160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3341 9147222 7.19 25.9 µM 9.60E-14 RNA processing & uracil transport 2 3.17E-13 1.72
2 SGTC_1207 2099-0101 6.23 141.0 µM 9.21E-11 1 2.27E-10 2.41
3 SGTC_1033 k072-0102 5.58 21.3 µM 5.97E-9 60S ribosome export 2 1.23E-8 0.69
4 SGTC_2351 9026858 5.25 72.3 µM 3.96E-8 RNA processing & uracil transport 6 7.56E-8 0.65
5 SGTC_184 1494-0393 4.79 24.7 µM 4.96E-7 20 8.51E-7 0.13
6 SGTC_1193 1488-0126 4.72 41.5 µM 6.87E-7 2 1.16E-6 0.47
7 SGTC_3019 9081971 4.57 49.5 µM 1.47E-6 1 2.42E-6 0.45
8 SGTC_2345 9052315 4.54 157.4 µM 1.73E-6 4 2.81E-6 0.03
9 SGTC_3347 9188721 4.53 44.7 µM 1.84E-6 9 3.00E-6 0.18
10 SGTC_1210 3013-0140 4.16 750.0 nM 1.05E-5 2 1.59E-5 0.00
11 SGTC_2320 7373003 4.06 200.0 µM 1.62E-5 8 2.40E-5 0.19
12 SGTC_674 0498-0004 4.05 451.0 µM 1.71E-5 heme requiring 20 2.54E-5 0.09
13 SGTC_1087 pterostilbene 3.97 9.1 µM 2.46E-5 5 3.58E-5 0.12
14 SGTC_3189 9110682 3.80 49.5 µM 5.06E-5 10 7.16E-5 0.18
15 SGTC_2357 9067248 3.70 200.0 µM 7.86E-5 4 1.09E-4 0.18
16 SGTC_2490 carminic acid 3.69 95.4 µM 7.95E-5 8 1.10E-4 0.12
17 SGTC_2162 5663267 3.68 200.0 µM 8.30E-5 13 1.15E-4 0.07
18 SGTC_977 1348-1378 3.61 135.0 µM 1.12E-4 11 1.54E-4 0.05
19 SGTC_2225 6654152 3.51 15.4 µM 1.65E-4 28 2.23E-4 0.01
20 SGTC_1006 4099-6547 3.50 255.0 µM 1.70E-4 6 2.29E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.22E-10 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.097 1.93E-8 YLR047C FRE8 hom Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
0.093 6.32E-8 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.080 3.68E-6 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.076 1.00E-5 YPR028W YOP1 hom Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress
0.074 1.80E-5 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.074 1.84E-5 YBL073W_d YBL073W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C
0.074 1.91E-5 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.071 3.49E-5 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.071 4.22E-5 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.070 4.47E-5 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.070 4.82E-5 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.067 9.71E-5 YPL122C TFB2 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
0.066 1.43E-4 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.065 1.60E-4 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive