YOR161C / PNS1

Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR161C / PNS1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:5.03|P-value:4.32E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.21|P-value:8.70E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.61|P-value:3.23E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.43|P-value:3.93E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.22|P-value:8.29E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.14|P-value:2.65E-5 ID:SGTC_1609|Compound:st001574|FD-Score:3.83|P-value:9.01E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.81|P-value:1.27E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.91|P-value:6.65E-5 ID:SGTC_1892|Compound:st058411|FD-Score:-3.34|P-value:5.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.93|P-value:6.16E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.25|P-value:7.50E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.04|P-value:3.89E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.66|P-value:2.56E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.18|P-value:9.52E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.91|P-value:6.48E-5 ID:SGTC_2966|Compound:9084041|FD-Score:4.13|P-value:2.64E-5 ID:SGTC_2969|Compound:9091408|FD-Score:5.24|P-value:1.47E-7 ID:SGTC_3062|Compound:9077494|FD-Score:3.20|P-value:8.79E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.77|P-value:1.14E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-4.20|P-value:2.02E-5 ID:SGTC_3140|Compound:9094243|FD-Score:5.29|P-value:1.17E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-3.18|P-value:9.53E-4 ID:SGTC_3198|Compound:9112019|FD-Score:5.04|P-value:4.13E-7 ID:SGTC_3206|Compound:9114350|FD-Score:4.29|P-value:1.36E-5 ID:SGTC_3208|Compound:9114115|FD-Score:5.13|P-value:2.63E-7 ID:SGTC_3262|Compound:9137218|FD-Score:-3.32|P-value:5.86E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.30|P-value:1.31E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:5.03|P-value:4.32E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.21|P-value:8.70E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.61|P-value:3.23E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.43|P-value:3.93E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.22|P-value:8.29E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.14|P-value:2.65E-5 ID:SGTC_1609|Compound:st001574|FD-Score:3.83|P-value:9.01E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.81|P-value:1.27E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.91|P-value:6.65E-5 ID:SGTC_1892|Compound:st058411|FD-Score:-3.34|P-value:5.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.93|P-value:6.16E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.25|P-value:7.50E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.04|P-value:3.89E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.66|P-value:2.56E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.18|P-value:9.52E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.91|P-value:6.48E-5 ID:SGTC_2966|Compound:9084041|FD-Score:4.13|P-value:2.64E-5 ID:SGTC_2969|Compound:9091408|FD-Score:5.24|P-value:1.47E-7 ID:SGTC_3062|Compound:9077494|FD-Score:3.20|P-value:8.79E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.77|P-value:1.14E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-4.20|P-value:2.02E-5 ID:SGTC_3140|Compound:9094243|FD-Score:5.29|P-value:1.17E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-3.18|P-value:9.53E-4 ID:SGTC_3198|Compound:9112019|FD-Score:5.04|P-value:4.13E-7 ID:SGTC_3206|Compound:9114350|FD-Score:4.29|P-value:1.36E-5 ID:SGTC_3208|Compound:9114115|FD-Score:5.13|P-value:2.63E-7 ID:SGTC_3262|Compound:9137218|FD-Score:-3.32|P-value:5.86E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.30|P-value:1.31E-5

Top fitness defect scores for YOR161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3140 9094243 5.29 49.5 µM 1.17E-7 9 6.25E-8
2 SGTC_2969 9091408 5.24 28.7 µM 1.47E-7 7 7.92E-8
3 SGTC_3208 9114115 5.13 49.5 µM 2.63E-7 16 1.45E-7
4 SGTC_3198 9112019 5.04 49.5 µM 4.13E-7 mitochondrial processes 3 2.32E-7
5 SGTC_73 0327-0325 5.03 16.2 µM 4.32E-7 DNA damage response 23 2.44E-7
6 SGTC_1636 st007707 4.81 68.9 µM 1.27E-6 32 7.51E-7
7 SGTC_2440 5628896 4.66 157.8 µM 2.56E-6 13 1.56E-6
8 SGTC_444 curcumin 4.61 90.4 µM 3.23E-6 iron homeostasis 14 1.99E-6
9 SGTC_3281 9140613 4.30 49.5 µM 1.31E-5 RPP1 & pyrimidine depletion 14 8.61E-6
10 SGTC_3206 9114350 4.29 49.5 µM 1.36E-5 11 8.94E-6
11 SGTC_2966 9084041 4.13 48.0 µM 2.64E-5 28 1.79E-5
12 SGTC_2286 7945697 4.04 125.0 µM 3.89E-5 52 2.68E-5
13 SGTC_2807 7945238 3.91 52.0 µM 6.48E-5 24 4.56E-5
14 SGTC_1735 st034310 3.91 56.8 µM 6.65E-5 Golgi 29 4.69E-5
15 SGTC_1609 st001574 3.83 46.4 µM 9.01E-5 13 6.44E-5
16 SGTC_3123 9126162 3.77 49.5 µM 1.14E-4 21 8.26E-5
17 SGTC_668 1682-0499 3.52 62.6 µM 2.91E-4 37 2.19E-4
18 SGTC_450 aminopyrene 3.44 156.0 nM 3.83E-4 56 2.91E-4
19 SGTC_599 1935-0052 3.43 86.5 µM 3.93E-4 28 2.99E-4
20 SGTC_1936 st074407 3.25 74.3 µM 7.50E-4 DNA damage response 74 5.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.51E-11 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.108 3.30E-10 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.108 3.35E-10 YJL077C ICS3 hom Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2
0.101 4.41E-9 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.094 4.97E-8 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.091 1.50E-7 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.089 2.41E-7 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
0.087 4.87E-7 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.086 5.46E-7 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.083 1.36E-6 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.081 2.49E-6 YLR281C_p YLR281C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.080 3.45E-6 YCL001W RER1 hom Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
0.080 3.95E-6 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.079 5.13E-6 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 8.24E-6 YFR003C YPI1 het Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance