YOR164C / GET4

Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR164C / GET4

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.54|P-value:5.61E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.42|P-value:2.40E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.88|P-value:1.74E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.73|P-value:2.93E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.89|P-value:1.73E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.75|P-value:6.12E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:6.25|P-value:4.51E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:4.35|P-value:3.14E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.49|P-value:7.32E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-4.20|P-value:6.27E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:5.41|P-value:3.25E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:3.46|P-value:7.15E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.65|P-value:1.21E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:3.46|P-value:7.23E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.43|P-value:7.83E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.56|P-value:5.24E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.40|P-value:8.66E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.42|P-value:8.18E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.62|P-value:4.33E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.60|P-value:4.59E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.59|P-value:4.73E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.55|P-value:5.95E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.35|P-value:4.21E-7 ID:SGTC_2053|Compound:5265679|FD-Score:4.91|P-value:3.09E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.53|P-value:5.75E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.42|P-value:2.39E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.93|P-value:1.45E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.71|P-value:7.39E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.20|P-value:9.91E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.84|P-value:4.17E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:3.75|P-value:2.77E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.35|P-value:3.49E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.64|P-value:4.39E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.43|P-value:2.31E-5 ID:SGTC_2971|Compound:9092186|FD-Score:4.26|P-value:4.36E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.52|P-value:5.91E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.74|P-value:2.90E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.47|P-value:2.45E-7 ID:SGTC_2989|Compound:9073649|FD-Score:-3.65|P-value:4.31E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-4.84|P-value:4.89E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:3.54|P-value:5.61E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.42|P-value:2.40E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.88|P-value:1.74E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.73|P-value:2.93E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.89|P-value:1.73E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.75|P-value:6.12E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:6.25|P-value:4.51E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:4.35|P-value:3.14E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.49|P-value:7.32E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-4.20|P-value:6.27E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:5.41|P-value:3.25E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:3.46|P-value:7.15E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.65|P-value:1.21E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:3.46|P-value:7.23E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.43|P-value:7.83E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.56|P-value:5.24E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.40|P-value:8.66E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.42|P-value:8.18E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.62|P-value:4.33E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.60|P-value:4.59E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.59|P-value:4.73E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.55|P-value:5.95E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.35|P-value:4.21E-7 ID:SGTC_2053|Compound:5265679|FD-Score:4.91|P-value:3.09E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.53|P-value:5.75E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.42|P-value:2.39E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.93|P-value:1.45E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.71|P-value:7.39E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.20|P-value:9.91E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.84|P-value:4.17E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:3.75|P-value:2.77E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.35|P-value:3.49E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.64|P-value:4.39E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.43|P-value:2.31E-5 ID:SGTC_2971|Compound:9092186|FD-Score:4.26|P-value:4.36E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.52|P-value:5.91E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.74|P-value:2.90E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.47|P-value:2.45E-7 ID:SGTC_2989|Compound:9073649|FD-Score:-3.65|P-value:4.31E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-4.84|P-value:4.89E-6

Top fitness defect scores for YOR164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_149 3970-0822 6.25 46.1 µM 4.51E-9 tubulin folding & SWR complex 34 2.03E-10
2 SGTC_2988 9073640 5.47 71.4 µM 2.45E-7 7 2.26E-8
3 SGTC_373 0844-0104 5.41 25.9 µM 3.25E-7 ERAD & cell cycle 26 3.17E-8
4 SGTC_1750 st081859 5.35 2.4 µM 4.21E-7 endomembrane recycling 124 4.29E-8
5 SGTC_2053 5265679 4.91 138.0 µM 3.09E-6 5 4.50E-7
6 SGTC_2615 purpurogallin-4-carboxylic acid 4.84 100.0 µM 4.17E-6 redox potentiating 45 6.41E-7
7 SGTC_119 0121-0043 4.75 24.8 µM 6.12E-6 mitochondrial stress 69 1.01E-6
8 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.71 70.0 µM 7.39E-6 redox potentiating 52 1.26E-6
9 SGTC_2937 9044753 4.43 11.3 µM 2.31E-5 60S ribosome export 23 4.79E-6
10 SGTC_2450 5739737 4.42 12.9 µM 2.39E-5 14 5.00E-6
11 SGTC_18 0111-0177 4.42 500.0 nM 2.40E-5 50 5.02E-6
12 SGTC_158 k038-0087 4.35 26.4 µM 3.14E-5 ubiquinone biosynthesis & proteasome 116 6.88E-6
13 SGTC_2971 9092186 4.26 9.9 µM 4.36E-5 ergosterol biosynthesis 21 1.01E-5
14 SGTC_2552 juarezic acid 3.93 87.0 µM 1.45E-4 TSC3-RPN4 39 4.16E-5
15 SGTC_114 0364-0001 3.89 490.3 µM 1.73E-4 52 5.11E-5
16 SGTC_50 0929-0078 3.88 56.4 µM 1.74E-4 48 5.13E-5
17 SGTC_2777 climbazole 3.75 1.5 µM 2.77E-4 iron homeostasis 59 8.89E-5
18 SGTC_2987 9018338 3.74 71.4 µM 2.90E-4 RPP1 & pyrimidine depletion 24 9.36E-5
19 SGTC_86 0417-1630 3.73 471.9 µM 2.93E-4 ubiquinone biosynthesis & proteasome 167 9.48E-5
20 SGTC_1165 k072-0275 3.62 30.3 µM 4.33E-4 51 1.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 2.98E-22 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.146 2.33E-17 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.145 2.54E-17 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.144 3.97E-17 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.144 5.50E-17 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.143 1.11E-16 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.137 1.61E-15 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.134 7.11E-15 YGR089W NNF2 hom Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
0.132 1.35E-14 YPR153W YPR153W hom Putative protein of unknown function
0.132 2.02E-14 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.128 9.20E-14 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.122 1.55E-12 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.118 5.79E-12 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.116 1.46E-11 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.113 4.47E-11 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels