YOR166C / SWT1

RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR166C / SWT1

Click on Significant Values for Screen Details ID:SGTC_307|Compound:1501-1223|FD-Score:-2.99|P-value:5.36E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.11|P-value:3.64E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:4.36|P-value:9.82E-7 ID:SGTC_398|Compound:bronopol|FD-Score:3.27|P-value:1.81E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.39|P-value:1.05E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.12|P-value:3.28E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.41|P-value:9.42E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.90|P-value:7.61E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:2.86|P-value:9.06E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.97|P-value:7.42E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:2.90|P-value:7.83E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-2.98|P-value:5.43E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.47|P-value:5.23E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.32|P-value:1.39E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.97|P-value:7.36E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:7.53|P-value:9.36E-17 ID:SGTC_797|Compound:k781-0471|FD-Score:4.26|P-value:1.62E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:-2.85|P-value:9.08E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-2.82|P-value:9.99E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.85|P-value:9.36E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.26|P-value:1.60E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.22|P-value:2.13E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.08|P-value:3.79E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.21|P-value:2.30E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:2.93|P-value:6.88E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.71|P-value:1.30E-7 ID:SGTC_1507|Compound:4075-3230|FD-Score:4.29|P-value:1.41E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.94|P-value:6.70E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.09|P-value:3.66E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:1.73E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.94|P-value:4.27E-11 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.00|P-value:5.23E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-2.86|P-value:8.73E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.14|P-value:3.03E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.52|P-value:6.13E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.97|P-value:7.36E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.87|P-value:8.75E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.05|P-value:4.18E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.21|P-value:2.24E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.19|P-value:2.40E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.72|P-value:1.98E-10 ID:SGTC_2700|Compound:st077718|FD-Score:-3.49|P-value:6.67E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.87|P-value:8.69E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.04|P-value:4.50E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-2.92|P-value:6.83E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.75|P-value:2.07E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.53|P-value:5.79E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-2.93|P-value:6.78E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.90|P-value:7.36E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.17|P-value:2.66E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-2.95|P-value:6.09E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.06|P-value:4.10E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.80|P-value:1.59E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-3.58|P-value:4.54E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.10|P-value:3.40E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-2.99|P-value:5.36E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:4.11|P-value:3.64E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:4.36|P-value:9.82E-7 ID:SGTC_398|Compound:bronopol|FD-Score:3.27|P-value:1.81E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.39|P-value:1.05E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.12|P-value:3.28E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.41|P-value:9.42E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.90|P-value:7.61E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:2.86|P-value:9.06E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.97|P-value:7.42E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:2.90|P-value:7.83E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-2.98|P-value:5.43E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.47|P-value:5.23E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.32|P-value:1.39E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.97|P-value:7.36E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:7.53|P-value:9.36E-17 ID:SGTC_797|Compound:k781-0471|FD-Score:4.26|P-value:1.62E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:-2.85|P-value:9.08E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-2.82|P-value:9.99E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.85|P-value:9.36E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.26|P-value:1.60E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.22|P-value:2.13E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.08|P-value:3.79E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.21|P-value:2.30E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:2.93|P-value:6.88E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.71|P-value:1.30E-7 ID:SGTC_1507|Compound:4075-3230|FD-Score:4.29|P-value:1.41E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.94|P-value:6.70E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.09|P-value:3.66E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:1.73E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.94|P-value:4.27E-11 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.00|P-value:5.23E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-2.86|P-value:8.73E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.14|P-value:3.03E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.52|P-value:6.13E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.97|P-value:7.36E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.87|P-value:8.75E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.05|P-value:4.18E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.21|P-value:2.24E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.19|P-value:2.40E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.72|P-value:1.98E-10 ID:SGTC_2700|Compound:st077718|FD-Score:-3.49|P-value:6.67E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.87|P-value:8.69E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.04|P-value:4.50E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-2.92|P-value:6.83E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.75|P-value:2.07E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.53|P-value:5.79E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-2.93|P-value:6.78E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.90|P-value:7.36E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.17|P-value:2.66E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-2.95|P-value:6.09E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.06|P-value:4.10E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.80|P-value:1.59E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-3.58|P-value:4.54E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.10|P-value:3.40E-4

Top fitness defect scores for YOR166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_769 0302-0231 7.53 76.0 µM 9.36E-17 4 2.51E-14
2 SGTC_1529 apigenin 5.94 74.0 µM 4.27E-11 6 1.42E-9
3 SGTC_662 k832-1615 4.47 104.0 µM 5.23E-7 11 3.91E-6
4 SGTC_358 0075-0058 4.36 9.4 µM 9.82E-7 47 6.65E-6
5 SGTC_1507 4075-3230 4.29 155.0 µM 1.41E-6 8 9.00E-6
6 SGTC_797 k781-0471 4.26 270.0 µM 1.62E-6 RPP1 & pyrimidine depletion 12 1.01E-5
7 SGTC_345 1362-0200 4.11 395.0 µM 3.64E-6 13 2.01E-5
8 SGTC_2030 5175110 3.97 200.0 µM 7.36E-6 Golgi 25 3.64E-5
9 SGTC_762 1165-0429 3.97 115.0 µM 7.36E-6 TSC3-RPN4 16 3.64E-5
10 SGTC_536 3852-0578 3.97 10.6 µM 7.42E-6 22 3.67E-5
11 SGTC_2842 9000675 3.75 19.5 µM 2.07E-5 26 8.70E-5
12 SGTC_2845 9003024 3.53 43.0 µM 5.79E-5 amide catabolism 61 2.08E-4
13 SGTC_1984 st072354 3.52 53.1 µM 6.13E-5 23 2.18E-4
14 SGTC_402 epigallocatechin gallate 3.39 10.0 µM 1.05E-4 56 3.43E-4
15 SGTC_1521 st012942 3.28 49.4 µM 1.73E-4 64 5.26E-4
16 SGTC_398 bronopol 3.27 33.3 µM 1.81E-4 RNA processing & uracil transport 44 5.46E-4
17 SGTC_2205 7238770 3.21 200.0 µM 2.24E-4 14 6.53E-4
18 SGTC_1377 2944-0135 3.21 198.0 µM 2.30E-4 calcium & mitochondrial duress 71 6.69E-4
19 SGTC_2986 9022445 3.17 71.4 µM 2.66E-4 39 7.56E-4
20 SGTC_1902 st060212 3.14 70.5 µM 3.03E-4 43 8.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.31E-26 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.175 1.83E-24 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.167 2.49E-22 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.161 5.68E-21 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.161 8.15E-21 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.158 2.79E-20 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.153 4.23E-19 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.135 4.65E-15 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.133 1.12E-14 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.132 1.51E-14 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.123 9.88E-13 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.122 1.09E-12 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.119 5.49E-12 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.113 5.13E-11 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.111 1.30E-10 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence