YOR168W / GLN4

Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR168W / GLN4

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.44|P-value:9.23E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-2.91|P-value:4.98E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.97|P-value:1.31E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.15|P-value:4.15E-9 ID:SGTC_438|Compound:sphingosine|FD-Score:2.91|P-value:8.12E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-2.91|P-value:4.99E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-2.85|P-value:6.44E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.05|P-value:4.85E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.54|P-value:6.12E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.13|P-value:3.52E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.39|P-value:1.16E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.62|P-value:2.32E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.89|P-value:2.10E-8 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.83|P-value:8.38E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:3.12|P-value:3.67E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.14|P-value:2.03E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.64|P-value:2.12E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.37|P-value:9.49E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.21|P-value:2.47E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.47|P-value:4.64E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.33|P-value:8.94E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.63|P-value:3.94E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.46|P-value:8.80E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.78|P-value:8.38E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.43|P-value:9.78E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.03|P-value:3.17E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.31|P-value:9.42E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.37|P-value:1.27E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.89|P-value:8.80E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.37|P-value:1.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.58|P-value:5.06E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.11|P-value:3.81E-6 ID:SGTC_1762|Compound:st045503|FD-Score:4.22|P-value:2.14E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.11|P-value:3.71E-4 ID:SGTC_2180|Compound:6301957|FD-Score:4.59|P-value:2.81E-7 ID:SGTC_2190|Compound:6049624|FD-Score:3.36|P-value:1.36E-4 ID:SGTC_2227|Compound:7312221|FD-Score:19.30|P-value:8.40E-101 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.77|P-value:4.51E-8 ID:SGTC_2237|Compound:6667747|FD-Score:8.64|P-value:1.16E-21 ID:SGTC_2240|Compound:6690706|FD-Score:3.55|P-value:5.64E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-6.22|P-value:1.86E-12 ID:SGTC_2312|Compound:7706453|FD-Score:2.99|P-value:5.96E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.55|P-value:5.67E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.06|P-value:1.62E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.16|P-value:3.13E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.36|P-value:1.31E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.05|P-value:4.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.88|P-value:9.13E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.01|P-value:3.39E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.11|P-value:3.81E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.10|P-value:3.96E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.99|P-value:6.15E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.43|P-value:9.61E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:7.98E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-2.75|P-value:9.43E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.40|P-value:7.87E-7 ID:SGTC_3112|Compound:9123419|FD-Score:3.62|P-value:4.09E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-3.15|P-value:1.87E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.77|P-value:1.13E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.95|P-value:8.78E-6 ID:SGTC_3187|Compound:9109394|FD-Score:4.01|P-value:6.47E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.44|P-value:9.23E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-2.91|P-value:4.98E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.97|P-value:1.31E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.15|P-value:4.15E-9 ID:SGTC_438|Compound:sphingosine|FD-Score:2.91|P-value:8.12E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-2.91|P-value:4.99E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-2.85|P-value:6.44E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.05|P-value:4.85E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.54|P-value:6.12E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.13|P-value:3.52E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.39|P-value:1.16E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.62|P-value:2.32E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.89|P-value:2.10E-8 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.83|P-value:8.38E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:3.12|P-value:3.67E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.14|P-value:2.03E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.64|P-value:2.12E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.37|P-value:9.49E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.21|P-value:2.47E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.47|P-value:4.64E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.33|P-value:8.94E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.63|P-value:3.94E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.46|P-value:8.80E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.78|P-value:8.38E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.43|P-value:9.78E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.03|P-value:3.17E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.31|P-value:9.42E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.37|P-value:1.27E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.89|P-value:8.80E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.37|P-value:1.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.58|P-value:5.06E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.11|P-value:3.81E-6 ID:SGTC_1762|Compound:st045503|FD-Score:4.22|P-value:2.14E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.11|P-value:3.71E-4 ID:SGTC_2180|Compound:6301957|FD-Score:4.59|P-value:2.81E-7 ID:SGTC_2190|Compound:6049624|FD-Score:3.36|P-value:1.36E-4 ID:SGTC_2227|Compound:7312221|FD-Score:19.30|P-value:8.40E-101 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.77|P-value:4.51E-8 ID:SGTC_2237|Compound:6667747|FD-Score:8.64|P-value:1.16E-21 ID:SGTC_2240|Compound:6690706|FD-Score:3.55|P-value:5.64E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-6.22|P-value:1.86E-12 ID:SGTC_2312|Compound:7706453|FD-Score:2.99|P-value:5.96E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.55|P-value:5.67E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.06|P-value:1.62E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.16|P-value:3.13E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.36|P-value:1.31E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.05|P-value:4.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.88|P-value:9.13E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.01|P-value:3.39E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.11|P-value:3.81E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.10|P-value:3.96E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.99|P-value:6.15E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.43|P-value:9.61E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:7.98E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-2.75|P-value:9.43E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.40|P-value:7.87E-7 ID:SGTC_3112|Compound:9123419|FD-Score:3.62|P-value:4.09E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-3.15|P-value:1.87E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.77|P-value:1.13E-5 ID:SGTC_3159|Compound:9100096|FD-Score:3.95|P-value:8.78E-6 ID:SGTC_3187|Compound:9109394|FD-Score:4.01|P-value:6.47E-6

Top fitness defect scores for YOR168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2227 7312221 19.30 64.1 µM 8.40E-101 1 2.33E-83 15.50
2 SGTC_2237 6667747 8.64 47.2 µM 1.16E-21 2 2.71E-18 4.04
3 SGTC_2405 ticlatone 5.06 3.5 µM 1.62E-8 15 2.08E-7 0.21
4 SGTC_2180 6301957 4.59 200.0 µM 2.81E-7 RSC complex & mRNA processing 6 2.24E-6 0.20
5 SGTC_3074 9116018 4.40 49.5 µM 7.87E-7 RNA processing & uracil transport 4 5.30E-6 0.07
6 SGTC_960 1222-0186 4.37 7.7 µM 9.49E-7 7 6.19E-6 0.40
7 SGTC_1762 st045503 4.22 25.5 µM 2.14E-6 4 1.22E-5 0.95
8 SGTC_1759 st043059 4.11 70.0 µM 3.81E-6 amide catabolism 4 1.98E-5 0.23
9 SGTC_3187 9109394 4.01 49.5 µM 6.47E-6 Golgi 7 3.08E-5 0.00
10 SGTC_3159 9100096 3.95 49.5 µM 8.78E-6 5 3.98E-5 0.36
11 SGTC_971 1315-0384 3.63 26.7 µM 3.94E-5 cell wall signaling 7 1.40E-4 0.05
12 SGTC_3112 9123419 3.62 49.5 µM 4.09E-5 RPP1 & pyrimidine depletion 8 1.45E-4 0.02
13 SGTC_1709 st033179 3.58 39.1 µM 5.06E-5 3 1.73E-4 0.12
14 SGTC_2240 6690706 3.55 185.9 µM 5.64E-5 9 1.90E-4 0.03
15 SGTC_2351 9026858 3.55 72.3 µM 5.67E-5 RNA processing & uracil transport 15 1.90E-4 0.48
16 SGTC_695 3505-6186 3.54 243.0 µM 6.12E-5 17 2.03E-4 0.06
17 SGTC_2949 9072542 3.48 2.2 µM 7.98E-5 TSC3-RPN4 19 2.54E-4 0.17
18 SGTC_1078 idebenone 3.46 36.1 µM 8.80E-5 Golgi 8 2.75E-4 0.16
19 SGTC_44 0929-0055 3.44 61.2 µM 9.23E-5 15 2.87E-4 0.20
20 SGTC_2942 9052777 3.43 62.2 µM 9.61E-5 12 2.96E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.462 2.00E-177 YOR169C_d YOR169C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
0.141 2.03E-16 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.109 2.20E-10 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.108 3.15E-10 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.093 7.78E-8 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.090 2.02E-7 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.23E-7 YPL240C HSP82 hom Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication
0.088 3.31E-7 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.085 7.80E-7 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.074 1.98E-5 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.073 2.14E-5 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.073 2.22E-5 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.073 2.44E-5 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.071 4.04E-5 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.069 5.85E-5 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor