YOR172W / YRM1

Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR172W / YRM1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.22|P-value:5.91E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.96|P-value:2.80E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:3.52|P-value:1.98E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.70|P-value:9.68E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.86|P-value:5.09E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.99|P-value:2.95E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.42|P-value:2.89E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:6.02|P-value:6.65E-10 ID:SGTC_822|Compound:1487-0950|FD-Score:3.16|P-value:7.28E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.46|P-value:2.46E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.33|P-value:3.97E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.17|P-value:6.90E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.79|P-value:6.67E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:-4.26|P-value:8.54E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.33|P-value:3.84E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.58|P-value:1.55E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.49|P-value:2.21E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.08|P-value:9.52E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.85|P-value:5.30E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.52|P-value:1.93E-4 ID:SGTC_2369|Compound:9071472|FD-Score:5.36|P-value:3.35E-8 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.13|P-value:7.96E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.69|P-value:1.17E-6 ID:SGTC_2917|Compound:7979103|FD-Score:-4.24|P-value:9.33E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.32|P-value:4.16E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.09|P-value:9.00E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.30|P-value:4.40E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.72|P-value:8.87E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.22|P-value:5.91E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.96|P-value:2.80E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:3.52|P-value:1.98E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.70|P-value:9.68E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.86|P-value:5.09E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.99|P-value:2.95E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.42|P-value:2.89E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:6.02|P-value:6.65E-10 ID:SGTC_822|Compound:1487-0950|FD-Score:3.16|P-value:7.28E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.46|P-value:2.46E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.33|P-value:3.97E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.17|P-value:6.90E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.79|P-value:6.67E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:-4.26|P-value:8.54E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.33|P-value:3.84E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.58|P-value:1.55E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.49|P-value:2.21E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.08|P-value:9.52E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.85|P-value:5.30E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.48|P-value:2.29E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.52|P-value:1.93E-4 ID:SGTC_2369|Compound:9071472|FD-Score:5.36|P-value:3.35E-8 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.13|P-value:7.96E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.69|P-value:1.17E-6 ID:SGTC_2917|Compound:7979103|FD-Score:-4.24|P-value:9.33E-6 ID:SGTC_3202|Compound:9113761|FD-Score:3.32|P-value:4.16E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.09|P-value:9.00E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.30|P-value:4.40E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.72|P-value:8.87E-5

Top fitness defect scores for YOR172W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_807 1315-0151 6.02 48.0 µM 6.65E-10 4 8.73E-10
2 SGTC_2369 9071472 5.36 200.0 µM 3.35E-8 5 4.14E-8
3 SGTC_2862 9027634 4.69 71.4 µM 1.17E-6 ERG2 19 1.38E-6
4 SGTC_432 NS 1619 3.99 61.3 µM 2.95E-5 27 3.32E-5
5 SGTC_342 k048-0088 3.86 23.3 µM 5.09E-5 RSC & ERG11 20 5.67E-5
6 SGTC_1781 st038725 3.85 66.3 µM 5.30E-5 NEO1 104 5.91E-5
7 SGTC_1124 fisetin 3.79 1.2 µM 6.67E-5 41 7.41E-5
8 SGTC_105 0111-0055 3.70 734.8 µM 9.68E-5 10 1.07E-4
9 SGTC_2570 licareol 3.68 100.0 µM 1.08E-4 39 1.19E-4
10 SGTC_2539 epi(13)torulosol 3.59 80.0 µM 1.49E-4 38 1.64E-4
11 SGTC_1259 0671-0132 3.58 43.0 µM 1.55E-4 35 1.70E-4
12 SGTC_61 0978-8327 3.52 98.6 µM 1.98E-4 ergosterol biosynthesis 42 2.17E-4
13 SGTC_1315 1237-0019 3.49 3.7 µM 2.21E-4 15 2.41E-4
14 SGTC_2070 5230947 3.48 200.0 µM 2.29E-4 21 2.50E-4
15 SGTC_826 1683-5028 3.46 118.0 µM 2.46E-4 29 2.68E-4
16 SGTC_631 k072-0230 3.42 41.5 µM 2.89E-4 60S ribosome export 33 3.15E-4
17 SGTC_1965 Pectolinarigenin 3.34 58.4 µM 3.89E-4 RPP1 & pyrimidine depletion 21 4.22E-4
18 SGTC_1035 k081-0041 3.33 55.2 µM 3.97E-4 Golgi 41 4.30E-4
19 SGTC_3202 9113761 3.32 49.5 µM 4.16E-4 77 4.51E-4
20 SGTC_10 0279-0212 3.22 42.6 µM 5.91E-4 TRP & mitochondrial translation 177 6.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.37E-16 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.117 1.20E-11 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.106 8.72E-10 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.100 6.90E-9 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.094 5.67E-8 YMR187C_p YMR187C_p hom Putative protein of unknown function; YMR187C is not an essential gene
0.087 4.26E-7 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.082 2.22E-6 YPL072W UBP16 hom Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
0.081 2.82E-6 YOL030W GAS5 hom 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
0.079 4.14E-6 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.079 4.53E-6 YIL094C LYS12 hom Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
0.078 5.34E-6 YPR196W_p YPR196W_p hom Putative maltose-responsive transcription factor
0.077 8.37E-6 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.077 8.66E-6 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.076 1.14E-5 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.29E-5 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2