YOR173W / DCS2

Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR173W / DCS2

Click on Significant Values for Screen Details ID:SGTC_381|Compound:3461-2219|FD-Score:3.24|P-value:5.87E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:5.01|P-value:2.82E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-4.33|P-value:8.64E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.20|P-value:6.92E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.09|P-value:9.88E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.14|P-value:9.28E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-7.22|P-value:3.76E-13 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.83|P-value:7.44E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.21|P-value:7.27E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.91|P-value:4.68E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.15|P-value:8.02E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.26|P-value:5.49E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.84|P-value:6.31E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.46|P-value:2.66E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-4.23|P-value:1.34E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.15|P-value:8.03E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.93|P-value:4.33E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.68|P-value:1.19E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.20|P-value:6.81E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.16|P-value:7.86E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.99|P-value:3.33E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.47|P-value:2.59E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.74|P-value:1.04E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.17|P-value:7.73E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.35|P-value:6.82E-6 ID:SGTC_2979|Compound:9012552|FD-Score:3.64|P-value:1.35E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.50|P-value:3.48E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-3.87|P-value:6.31E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.24|P-value:5.87E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:5.01|P-value:2.82E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-4.33|P-value:8.64E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.20|P-value:6.92E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.09|P-value:9.88E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.14|P-value:9.28E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-7.22|P-value:3.76E-13 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.83|P-value:7.44E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.21|P-value:7.27E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.91|P-value:4.68E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.15|P-value:8.02E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.26|P-value:5.49E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.84|P-value:6.31E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.46|P-value:2.66E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-4.23|P-value:1.34E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.15|P-value:8.03E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.93|P-value:4.33E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.68|P-value:1.19E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.20|P-value:6.81E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.16|P-value:7.86E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.99|P-value:3.33E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.47|P-value:2.59E-4 ID:SGTC_2916|Compound:7875993|FD-Score:-3.74|P-value:1.04E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.17|P-value:7.73E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.35|P-value:6.82E-6 ID:SGTC_2979|Compound:9012552|FD-Score:3.64|P-value:1.35E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.50|P-value:3.48E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-3.87|P-value:6.31E-5

Top fitness defect scores for YOR173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_797 k781-0471 5.01 270.0 µM 2.82E-7 RPP1 & pyrimidine depletion 5 2.70E-7
2 SGTC_2307 7538926 4.93 6.3 µM 4.33E-7 19 4.16E-7
3 SGTC_2992 9074591 4.50 71.4 µM 3.48E-6 9 3.38E-6
4 SGTC_2969 9091408 4.35 28.7 µM 6.82E-6 18 6.66E-6
5 SGTC_2634 4'-methoxyflavone 3.99 100.0 µM 3.33E-5 32 3.29E-5
6 SGTC_1276 0871-0068 3.91 94.2 µM 4.68E-5 16 4.62E-5
7 SGTC_1850 st056238 3.84 17.0 µM 6.31E-5 RPP1 & pyrimidine depletion 25 6.24E-5
8 SGTC_1191 1487-1166 3.68 10.6 µM 1.18E-4 azole & statin 40 1.17E-4
9 SGTC_2405 ticlatone 3.68 3.5 µM 1.19E-4 76 1.18E-4
10 SGTC_2979 9012552 3.64 45.5 µM 1.35E-4 13 1.34E-4
11 SGTC_977 1348-1378 3.64 135.0 µM 1.36E-4 30 1.35E-4
12 SGTC_2412 st077135 3.60 33.4 µM 1.60E-4 36 1.59E-4
13 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.52 54.9 µM 2.20E-4 redox potentiating 72 2.19E-4
14 SGTC_2806 7952793 3.47 58.4 µM 2.59E-4 40 2.58E-4
15 SGTC_1959 st077091 3.46 55.8 µM 2.66E-4 RPP1 & pyrimidine depletion 64 2.65E-4
16 SGTC_1836 st055642 3.26 81.0 µM 5.49E-4 48 5.49E-4
17 SGTC_381 3461-2219 3.24 42.7 µM 5.87E-4 copper-dependent oxidative stress 44 5.88E-4
18 SGTC_2416 tofa 3.20 880.0 nM 6.81E-4 sphingolipid biosynthesis & PDR1 86 6.81E-4
19 SGTC_1006 4099-6547 3.20 255.0 µM 6.92E-4 54 6.93E-4
20 SGTC_2968 9090663 3.17 33.4 µM 7.73E-4 61 7.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 8.19E-17 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.133 9.51E-15 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.133 1.28E-14 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 2.76E-12 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.106 7.25E-10 YMR141C_d YMR141C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.19E-8 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.091 1.49E-7 YHL036W MUP3 hom Low affinity methionine permease, similar to Mup1p
0.089 2.20E-7 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.086 5.81E-7 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.085 8.02E-7 YKR022C NTR2 het Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
0.083 1.30E-6 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.080 3.10E-6 YGL192W IME4 hom Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
0.080 3.78E-6 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.079 4.32E-6 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.077 7.79E-6 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene