YOR175C / ALE1

Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR175C / ALE1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.85|P-value:7.08E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.20|P-value:7.43E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.85|P-value:7.07E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-4.62|P-value:2.29E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:7.91|P-value:2.72E-15 ID:SGTC_770|Compound:0389-1121|FD-Score:4.23|P-value:1.44E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.30|P-value:1.00E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.06|P-value:3.05E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.75|P-value:6.50E-9 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.55|P-value:2.25E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.50|P-value:2.73E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.61|P-value:1.75E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.66|P-value:1.49E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:-3.13|P-value:9.37E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.56|P-value:2.21E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.22|P-value:7.11E-4 ID:SGTC_1530|Compound:rhein|FD-Score:7.11|P-value:1.01E-12 ID:SGTC_1612|Compound:st002233|FD-Score:-3.79|P-value:8.50E-5 ID:SGTC_1708|Compound:st033234|FD-Score:-3.17|P-value:8.33E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.22|P-value:1.55E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.70|P-value:1.32E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.43|P-value:3.58E-4 ID:SGTC_1971|Compound:st069429|FD-Score:5.61|P-value:1.50E-8 ID:SGTC_2014|Compound:4013930|FD-Score:3.22|P-value:7.29E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.16|P-value:8.54E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.50|P-value:2.59E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.59|P-value:1.94E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.46|P-value:3.18E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.88|P-value:7.24E-7 ID:SGTC_2671|Compound:danthron|FD-Score:-3.42|P-value:3.44E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.24|P-value:6.98E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.44|P-value:3.23E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.53|P-value:2.35E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-3.24|P-value:6.47E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.62|P-value:1.75E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.66|P-value:1.43E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.32|P-value:7.33E-8 ID:SGTC_3156|Compound:9099931|FD-Score:3.56|P-value:2.22E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-4.50|P-value:4.14E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.61|P-value:1.74E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.21|P-value:7.69E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.85|P-value:7.08E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.20|P-value:7.43E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.85|P-value:7.07E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-4.62|P-value:2.29E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:7.91|P-value:2.72E-15 ID:SGTC_770|Compound:0389-1121|FD-Score:4.23|P-value:1.44E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.30|P-value:1.00E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.06|P-value:3.05E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.75|P-value:6.50E-9 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.55|P-value:2.25E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.50|P-value:2.73E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.61|P-value:1.75E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.66|P-value:1.49E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.32|P-value:5.32E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:-3.13|P-value:9.37E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.56|P-value:2.21E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.22|P-value:7.11E-4 ID:SGTC_1530|Compound:rhein|FD-Score:7.11|P-value:1.01E-12 ID:SGTC_1612|Compound:st002233|FD-Score:-3.79|P-value:8.50E-5 ID:SGTC_1708|Compound:st033234|FD-Score:-3.17|P-value:8.33E-4 ID:SGTC_1958|Compound:st076513|FD-Score:4.22|P-value:1.55E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.70|P-value:1.32E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.43|P-value:3.58E-4 ID:SGTC_1971|Compound:st069429|FD-Score:5.61|P-value:1.50E-8 ID:SGTC_2014|Compound:4013930|FD-Score:3.22|P-value:7.29E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.16|P-value:8.54E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.50|P-value:2.59E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.59|P-value:1.94E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.46|P-value:3.18E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.88|P-value:7.24E-7 ID:SGTC_2671|Compound:danthron|FD-Score:-3.42|P-value:3.44E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.24|P-value:6.98E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.44|P-value:3.23E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.53|P-value:2.35E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-3.24|P-value:6.47E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.62|P-value:1.75E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.66|P-value:1.43E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.32|P-value:7.33E-8 ID:SGTC_3156|Compound:9099931|FD-Score:3.56|P-value:2.22E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-4.50|P-value:4.14E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.61|P-value:1.74E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.21|P-value:7.69E-4

Top fitness defect scores for YOR175C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_767 0929-0023 7.91 86.0 µM 2.72E-15 TRP & mitochondrial translation 11 1.32E-15
2 SGTC_1530 rhein 7.11 70.4 µM 1.01E-12 2 5.60E-13
3 SGTC_1047 2043-3044 5.75 82.0 µM 6.50E-9 9 4.36E-9
4 SGTC_1971 st069429 5.61 63.5 µM 1.50E-8 60S ribosome export 3 1.02E-8
5 SGTC_1324 1418-0026 5.50 34.4 µM 2.73E-8 2 1.89E-8
6 SGTC_3133 9127736 5.32 49.5 µM 7.33E-8 2 5.19E-8
7 SGTC_2663 amphotericin b 4.88 100.0 µM 7.24E-7 3 5.39E-7
8 SGTC_770 0389-1121 4.23 67.2 µM 1.44E-5 RPP1 & pyrimidine depletion 19 1.14E-5
9 SGTC_1958 st076513 4.22 41.9 µM 1.55E-5 60S ribosome export 25 1.23E-5
10 SGTC_1011 4112-3381 4.06 17.4 µM 3.05E-5 39 2.47E-5
11 SGTC_727 3032-0951 3.85 202.0 µM 7.07E-5 30 5.81E-5
12 SGTC_65 0798-0905 3.85 35.0 µM 7.08E-5 calcium & mitochondrial duress 90 5.83E-5
13 SGTC_1961 st076550 3.70 68.7 µM 1.32E-4 16 1.10E-4
14 SGTC_1382 3002-2117 3.66 298.0 µM 1.49E-4 17 1.25E-4
15 SGTC_1213 1315-0166 3.66 115.0 µM 1.52E-4 40 1.27E-4
16 SGTC_2987 9018338 3.62 71.4 µM 1.75E-4 RPP1 & pyrimidine depletion 31 1.47E-4
17 SGTC_2654 protoveratrine a 3.59 100.0 µM 1.94E-4 15 1.63E-4
18 SGTC_1422 4031-0024 3.56 15.5 µM 2.21E-4 iron homeostasis 25 1.87E-4
19 SGTC_3156 9099931 3.56 49.5 µM 2.22E-4 15 1.88E-4
20 SGTC_1054 3429-0080 3.55 167.0 µM 2.25E-4 36 1.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.13E-8 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.086 5.47E-7 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.082 1.89E-6 YDL017W CDC7 het DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p
0.080 3.46E-6 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.080 3.98E-6 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.074 1.94E-5 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.074 2.00E-5 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.070 4.70E-5 YMR232W FUS2 hom Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating
0.068 7.60E-5 YJL112W MDV1 hom Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
0.068 7.64E-5 YCL026C-B HBN1 hom Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.068 8.03E-5 YBL090W MRP21 hom Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
0.066 1.35E-4 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.066 1.36E-4 YIL062C ARC15 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity
0.065 1.48E-4 YNL053W MSG5 hom Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p
0.065 1.66E-4 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering