Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR176W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.166 | 3.57E-22 | YDL123W | SNA4 | hom | Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated |
0.127 | 1.57E-13 | YDR223W | CRF1 | hom | Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain |
0.125 | 3.13E-13 | YPL228W | CET1 | het | Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |
0.118 | 6.45E-12 | YDL205C | HEM3 | het | Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme |
0.112 | 6.63E-11 | YHR021W-A_p | ECM12_p | hom | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity |
0.109 | 2.33E-10 | YBL103C | RTG3 | hom | Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways |
0.107 | 6.09E-10 | YGR270W | YTA7 | hom | Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p |
0.103 | 2.02E-9 | YOL067C | RTG1 | hom | Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus |
0.103 | 2.38E-9 | YPR082C | DIB1 | het | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
0.098 | 1.40E-8 | YGR199W | PMT6 | hom | Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases |
0.097 | 1.81E-8 | YMR043W | MCM1 | het | Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes |
0.096 | 2.27E-8 | YBR035C | PDX3 | hom | Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism |
0.095 | 3.05E-8 | YOR155C | ISN1 | hom | Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms |
0.092 | 8.24E-8 | YLR103C | CDC45 | het | DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes |
0.091 | 1.32E-7 | YKR071C | DRE2 | het | Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress |