YOR177C / MPC54

Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR177C / MPC54

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:3.91|P-value:6.98E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.68|P-value:1.48E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.34|P-value:5.12E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.64|P-value:3.05E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:4.03|P-value:4.36E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.65|P-value:1.92E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.94|P-value:7.30E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.48|P-value:3.08E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.30|P-value:1.41E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.24|P-value:8.19E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.31|P-value:5.65E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.40|P-value:4.18E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.54|P-value:2.54E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.54|P-value:2.84E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.84|P-value:1.01E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:5.23|P-value:1.70E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.09|P-value:2.99E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.56|P-value:2.92E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.38|P-value:5.05E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.79|P-value:1.12E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.36|P-value:5.45E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.55|P-value:2.73E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.30|P-value:1.42E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.29|P-value:6.89E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.95|P-value:7.10E-7 ID:SGTC_1633|Compound:st005664|FD-Score:3.62|P-value:2.16E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.37|P-value:5.25E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.30|P-value:6.55E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.82|P-value:1.00E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.29|P-value:6.86E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.94|P-value:6.17E-5 ID:SGTC_1936|Compound:st074407|FD-Score:5.49|P-value:4.43E-8 ID:SGTC_2019|Compound:4016004|FD-Score:-3.35|P-value:5.00E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.18|P-value:9.91E-4 ID:SGTC_2208|Compound:7283366|FD-Score:5.86|P-value:5.51E-9 ID:SGTC_2219|Compound:9098279|FD-Score:4.50|P-value:5.78E-6 ID:SGTC_2225|Compound:6654152|FD-Score:3.94|P-value:6.28E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.31|P-value:1.33E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.28|P-value:7.14E-4 ID:SGTC_2329|Compound:6138490|FD-Score:10.10|P-value:3.33E-23 ID:SGTC_2339|Compound:9000433|FD-Score:4.89|P-value:9.50E-7 ID:SGTC_2411|Compound:st077133|FD-Score:4.24|P-value:1.78E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.35|P-value:5.64E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.19|P-value:9.50E-4 ID:SGTC_2463|Compound:5473429|FD-Score:5.77|P-value:9.24E-9 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.18|P-value:8.97E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.53|P-value:2.92E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.91|P-value:7.11E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.44|P-value:4.05E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.71|P-value:2.25E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.44|P-value:4.05E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.47|P-value:3.68E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.57|P-value:2.58E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.85|P-value:7.78E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.37|P-value:4.62E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.93|P-value:5.69E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.67|P-value:2.62E-6 ID:SGTC_3039|Compound:9090270|FD-Score:4.09|P-value:3.39E-5 ID:SGTC_3226|Compound:9131256|FD-Score:4.20|P-value:2.13E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-3.39|P-value:4.30E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.32|P-value:6.18E-4 ID:SGTC_3315|Compound:9136395|FD-Score:4.38|P-value:1.01E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.27|P-value:7.41E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.91|P-value:6.98E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.68|P-value:1.48E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.34|P-value:5.12E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.64|P-value:3.05E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:4.03|P-value:4.36E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.65|P-value:1.92E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.94|P-value:7.30E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.48|P-value:3.08E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.30|P-value:1.41E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.24|P-value:8.19E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.31|P-value:5.65E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.40|P-value:4.18E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.54|P-value:2.54E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.54|P-value:2.84E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.84|P-value:1.01E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:5.23|P-value:1.70E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.09|P-value:2.99E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.56|P-value:2.92E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.38|P-value:5.05E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.79|P-value:1.12E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.36|P-value:5.45E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.55|P-value:2.73E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.30|P-value:1.42E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.29|P-value:6.89E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.95|P-value:7.10E-7 ID:SGTC_1633|Compound:st005664|FD-Score:3.62|P-value:2.16E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.37|P-value:5.25E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.30|P-value:6.55E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.82|P-value:1.00E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.29|P-value:6.86E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.94|P-value:6.17E-5 ID:SGTC_1936|Compound:st074407|FD-Score:5.49|P-value:4.43E-8 ID:SGTC_2019|Compound:4016004|FD-Score:-3.35|P-value:5.00E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.18|P-value:9.91E-4 ID:SGTC_2208|Compound:7283366|FD-Score:5.86|P-value:5.51E-9 ID:SGTC_2219|Compound:9098279|FD-Score:4.50|P-value:5.78E-6 ID:SGTC_2225|Compound:6654152|FD-Score:3.94|P-value:6.28E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.31|P-value:1.33E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.28|P-value:7.14E-4 ID:SGTC_2329|Compound:6138490|FD-Score:10.10|P-value:3.33E-23 ID:SGTC_2339|Compound:9000433|FD-Score:4.89|P-value:9.50E-7 ID:SGTC_2411|Compound:st077133|FD-Score:4.24|P-value:1.78E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.35|P-value:5.64E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.19|P-value:9.50E-4 ID:SGTC_2463|Compound:5473429|FD-Score:5.77|P-value:9.24E-9 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.18|P-value:8.97E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.53|P-value:2.92E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.91|P-value:7.11E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.44|P-value:4.05E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.71|P-value:2.25E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.44|P-value:4.05E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.47|P-value:3.68E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.57|P-value:2.58E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.85|P-value:7.78E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.37|P-value:4.62E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.93|P-value:5.69E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.67|P-value:2.62E-6 ID:SGTC_3039|Compound:9090270|FD-Score:4.09|P-value:3.39E-5 ID:SGTC_3226|Compound:9131256|FD-Score:4.20|P-value:2.13E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-3.39|P-value:4.30E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.32|P-value:6.18E-4 ID:SGTC_3315|Compound:9136395|FD-Score:4.38|P-value:1.01E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.27|P-value:7.41E-4

Top fitness defect scores for YOR177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2329 6138490 10.10 200.0 µM 3.33E-23 2 2.99E-24
2 SGTC_2208 7283366 5.86 200.0 µM 5.51E-9 1 2.31E-9
3 SGTC_2463 5473429 5.77 200.0 µM 9.24E-9 ERG2 3 3.98E-9
4 SGTC_1040 k898-0338 5.56 155.0 µM 2.92E-8 4 1.33E-8
5 SGTC_1936 st074407 5.49 74.3 µM 4.43E-8 DNA damage response 8 2.05E-8
6 SGTC_971 1315-0384 5.23 26.7 µM 1.70E-7 cell wall signaling 4 8.40E-8
7 SGTC_1624 st003710 4.95 6.2 µM 7.10E-7 calcium & mitochondrial duress 23 3.75E-7
8 SGTC_183 3914-0051 4.94 30.6 µM 7.30E-7 60S ribosome export 7 3.86E-7
9 SGTC_2339 9000433 4.89 200.0 µM 9.50E-7 13 5.09E-7
10 SGTC_2634 4'-methoxyflavone 4.71 100.0 µM 2.25E-6 17 1.26E-6
11 SGTC_2921 7974240 4.67 10.7 µM 2.62E-6 31 1.47E-6
12 SGTC_135 0933-0004 4.64 26.4 µM 3.05E-6 60S ribosome export 11 1.73E-6
13 SGTC_2219 9098279 4.50 200.0 µM 5.78E-6 2 3.38E-6
14 SGTC_3315 9136395 4.38 68.5 µM 1.01E-5 5 6.03E-6
15 SGTC_2318 6029776 4.31 164.0 µM 1.33E-5 14 8.10E-6
16 SGTC_341 1486-1430 4.30 230.0 µM 1.41E-5 18 8.56E-6
17 SGTC_1256 0570-0116 4.30 285.0 µM 1.42E-5 13 8.65E-6
18 SGTC_2411 st077133 4.24 39.9 µM 1.78E-5 RNA pol III & RNase P/MRP 24 1.10E-5
19 SGTC_3226 9131256 4.20 49.5 µM 2.13E-5 1 1.32E-5
20 SGTC_3039 9090270 4.09 49.5 µM 3.39E-5 RPP1 & pyrimidine depletion 7 2.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 7.19E-20 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.137 1.72E-15 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.128 1.47E-13 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.122 1.15E-12 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.111 1.24E-10 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.105 1.05E-9 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.093 5.81E-8 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.090 1.57E-7 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.088 2.88E-7 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.086 6.23E-7 YKL108W SLD2 het Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
0.084 1.01E-6 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.081 2.53E-6 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.080 3.46E-6 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.079 4.70E-6 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases
0.074 1.80E-5 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C