YOR178C / GAC1

Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR178C / GAC1

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:4.11|P-value:2.15E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.38|P-value:3.88E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:4.10|P-value:2.28E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.72|P-value:1.34E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:4.22|P-value:1.37E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:3.16|P-value:8.51E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.88|P-value:5.34E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.31|P-value:5.06E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.37|P-value:6.36E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.66|P-value:1.30E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.56|P-value:1.90E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.34|P-value:7.38E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.28|P-value:1.04E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.25|P-value:5.80E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.62|P-value:1.52E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.49|P-value:2.60E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.70|P-value:1.17E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.28|P-value:5.64E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.50|P-value:2.56E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.92|P-value:4.91E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.11|P-value:9.90E-4 ID:SGTC_2213|Compound:7173844|FD-Score:4.30|P-value:9.64E-6 ID:SGTC_2291|Compound:7917025|FD-Score:7.69|P-value:1.02E-14 ID:SGTC_2332|Compound:7982454|FD-Score:5.40|P-value:3.92E-8 ID:SGTC_2336|Compound:9001819|FD-Score:6.72|P-value:1.18E-11 ID:SGTC_2460|Compound:5552655|FD-Score:4.11|P-value:2.21E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.86|P-value:2.81E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.16|P-value:8.16E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.09|P-value:2.28E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.32|P-value:8.57E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.40|P-value:3.47E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.03|P-value:3.14E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.43|P-value:3.14E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.52|P-value:2.34E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.42|P-value:3.35E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.28|P-value:5.62E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:4.11|P-value:2.15E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.38|P-value:3.88E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:4.10|P-value:2.28E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.72|P-value:1.34E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:4.22|P-value:1.37E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:3.16|P-value:8.51E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.88|P-value:5.34E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.31|P-value:5.06E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.37|P-value:6.36E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.66|P-value:1.30E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.56|P-value:1.90E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-4.34|P-value:7.38E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.28|P-value:1.04E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.25|P-value:5.80E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.62|P-value:1.52E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.49|P-value:2.60E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.70|P-value:1.17E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.28|P-value:5.64E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.50|P-value:2.56E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.92|P-value:4.91E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.11|P-value:9.90E-4 ID:SGTC_2213|Compound:7173844|FD-Score:4.30|P-value:9.64E-6 ID:SGTC_2291|Compound:7917025|FD-Score:7.69|P-value:1.02E-14 ID:SGTC_2332|Compound:7982454|FD-Score:5.40|P-value:3.92E-8 ID:SGTC_2336|Compound:9001819|FD-Score:6.72|P-value:1.18E-11 ID:SGTC_2460|Compound:5552655|FD-Score:4.11|P-value:2.21E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.86|P-value:2.81E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.16|P-value:8.16E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.09|P-value:2.28E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.32|P-value:8.57E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.40|P-value:3.47E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.03|P-value:3.14E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.43|P-value:3.14E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.52|P-value:2.34E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.42|P-value:3.35E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.28|P-value:5.62E-4

Top fitness defect scores for YOR178C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2291 7917025 7.69 104.3 µM 1.02E-14 iron homeostasis 18 7.57E-15
2 SGTC_2336 9001819 6.72 198.7 µM 1.18E-11 heme biosynthesis & mitochondrial translocase 2 9.38E-12
3 SGTC_2528 xanthyletin 5.86 44.8 µM 2.81E-9 5 2.34E-9
4 SGTC_2332 7982454 5.40 138.9 µM 3.92E-8 23 3.35E-8
5 SGTC_604 1000-0114 4.72 314.0 µM 1.34E-6 7 1.18E-6
6 SGTC_2729 fluphenazine 4.32 10.7 µM 8.57E-6 8 7.67E-6
7 SGTC_2213 7173844 4.30 200.0 µM 9.64E-6 11 8.65E-6
8 SGTC_1303 1160-0052 4.28 261.0 µM 1.04E-5 6 9.34E-6
9 SGTC_623 k072-0108 4.22 16.9 µM 1.37E-5 heme biosynthesis & mitochondrial translocase 10 1.24E-5
10 SGTC_89 0302-0250 4.11 142.1 µM 2.15E-5 14 1.95E-5
11 SGTC_2460 5552655 4.11 174.2 µM 2.21E-5 amide catabolism 28 2.00E-5
12 SGTC_600 1495-0418 4.10 41.6 µM 2.28E-5 RPP1 & pyrimidine depletion 6 2.06E-5
13 SGTC_2831 7999036 4.03 19.5 µM 3.14E-5 44 2.85E-5
14 SGTC_2099 5377090 3.92 177.4 µM 4.91E-5 23 4.47E-5
15 SGTC_3026 9090633 3.71 49.5 µM 1.11E-4 27 1.02E-4
16 SGTC_1836 st055642 3.70 81.0 µM 1.17E-4 22 1.08E-4
17 SGTC_2870 9038528 3.52 13.0 µM 2.34E-4 28 2.16E-4
18 SGTC_2069 5228469 3.50 200.0 µM 2.56E-4 26 2.36E-4
19 SGTC_1564 D-Arginine 3.49 115.0 µM 2.60E-4 46 2.40E-4
20 SGTC_3047 9092122 3.42 49.5 µM 3.35E-4 40 3.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 1.69E-39 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.130 4.90E-14 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.104 1.84E-9 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.094 5.41E-8 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.093 7.99E-8 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.093 7.94E-8 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.089 2.79E-7 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.085 9.59E-7 YBL049W MOH1 hom Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase
0.084 1.19E-6 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.083 1.70E-6 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.081 2.77E-6 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.080 3.96E-6 YDR190C RVB1 het ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.078 5.60E-6 YKR101W SIR1 hom Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
0.077 9.19E-6 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.075 1.35E-5 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme