YOR179C / SYC1

Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR179C / SYC1

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.18|P-value:6.03E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.22|P-value:5.02E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.62|P-value:1.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.74|P-value:1.68E-23 ID:SGTC_114|Compound:0364-0001|FD-Score:3.80|P-value:5.58E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:4.82|P-value:4.62E-7 ID:SGTC_140|Compound:0062-0056|FD-Score:3.66|P-value:9.65E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.09|P-value:8.28E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.04|P-value:9.92E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.02|P-value:2.15E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.73|P-value:7.46E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.05|P-value:9.72E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.65|P-value:1.10E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:3.95|P-value:2.96E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.17|P-value:6.32E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.58|P-value:1.27E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.21|P-value:5.41E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:6.46|P-value:2.38E-11 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.37|P-value:3.08E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.72|P-value:7.56E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.56|P-value:1.42E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.24|P-value:4.63E-4 ID:SGTC_1686|Compound:st019653|FD-Score:5.17|P-value:7.23E-8 ID:SGTC_1971|Compound:st069429|FD-Score:4.04|P-value:1.98E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.68|P-value:8.93E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-4.78|P-value:5.27E-7 ID:SGTC_2191|Compound:5911152|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.04|P-value:9.93E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.62|P-value:1.08E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.50|P-value:1.81E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_2266|Compound:7929956|FD-Score:5.11|P-value:9.87E-8 ID:SGTC_2303|Compound:7774051|FD-Score:3.21|P-value:5.36E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.00|P-value:5.09E-13 ID:SGTC_2328|Compound:6201408|FD-Score:4.22|P-value:8.58E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.98|P-value:2.52E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.09|P-value:8.46E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.86|P-value:4.20E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-3.72|P-value:7.24E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.98|P-value:2.59E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.04|P-value:9.97E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.07|P-value:9.02E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.05|P-value:9.26E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.46|P-value:2.16E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.47|P-value:2.05E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.33|P-value:3.56E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.18|P-value:6.03E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.22|P-value:5.02E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.62|P-value:1.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.74|P-value:1.68E-23 ID:SGTC_114|Compound:0364-0001|FD-Score:3.80|P-value:5.58E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:4.82|P-value:4.62E-7 ID:SGTC_140|Compound:0062-0056|FD-Score:3.66|P-value:9.65E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.09|P-value:8.28E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.04|P-value:9.92E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.02|P-value:2.15E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.73|P-value:7.46E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:3.57|P-value:1.39E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.05|P-value:9.72E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.65|P-value:1.10E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:3.95|P-value:2.96E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.17|P-value:6.32E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.58|P-value:1.27E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.21|P-value:5.41E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:6.46|P-value:2.38E-11 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.37|P-value:3.08E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.72|P-value:7.56E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.56|P-value:1.42E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.24|P-value:4.63E-4 ID:SGTC_1686|Compound:st019653|FD-Score:5.17|P-value:7.23E-8 ID:SGTC_1971|Compound:st069429|FD-Score:4.04|P-value:1.98E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.68|P-value:8.93E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-4.78|P-value:5.27E-7 ID:SGTC_2191|Compound:5911152|FD-Score:3.59|P-value:1.28E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.04|P-value:9.93E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.62|P-value:1.08E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.50|P-value:1.81E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_2266|Compound:7929956|FD-Score:5.11|P-value:9.87E-8 ID:SGTC_2303|Compound:7774051|FD-Score:3.21|P-value:5.36E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.00|P-value:5.09E-13 ID:SGTC_2328|Compound:6201408|FD-Score:4.22|P-value:8.58E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.98|P-value:2.52E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.09|P-value:8.46E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.86|P-value:4.20E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-3.72|P-value:7.24E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.98|P-value:2.59E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.04|P-value:9.97E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.07|P-value:9.02E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.05|P-value:9.26E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.46|P-value:2.16E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.47|P-value:2.05E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.33|P-value:3.56E-4

Top fitness defect scores for YOR179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.74 9.0 µM 1.68E-23 cell wall 84 1.03E-22
2 SGTC_2322 7413319 7.00 38.2 µM 5.09E-13 ERAD & cell cycle 50 1.30E-12
3 SGTC_960 1222-0186 6.46 7.7 µM 2.38E-11 5 5.27E-11
4 SGTC_1686 st019653 5.17 115.5 µM 7.23E-8 mitochondrial processes 1 1.20E-7
5 SGTC_2266 7929956 5.11 200.0 µM 9.87E-8 11 1.62E-7
6 SGTC_139 0099-0334 4.82 718.6 µM 4.62E-7 13 7.19E-7
7 SGTC_627 1391-0720 4.65 175.0 µM 1.10E-6 5 1.67E-6
8 SGTC_2328 6201408 4.22 200.0 µM 8.58E-6 15 1.21E-5
9 SGTC_2250 alverine citrate 4.05 130.0 µM 1.89E-5 147 2.59E-5
10 SGTC_1971 st069429 4.04 63.5 µM 1.98E-5 60S ribosome export 12 2.70E-5
11 SGTC_206 4546-0025 4.02 72.0 µM 2.15E-5 NEO1 68 2.92E-5
12 SGTC_2384 9036245 3.98 200.0 µM 2.52E-5 27 3.41E-5
13 SGTC_2688 kanamycin b 3.98 96.7 µM 2.59E-5 calcium & mitochondrial duress 360 3.50E-5
14 SGTC_632 0781-2353 3.95 4.7 µM 2.96E-5 Golgi 45 3.99E-5
15 SGTC_2480 5767542 3.86 37.2 µM 4.20E-5 11 5.58E-5
16 SGTC_114 0364-0001 3.80 490.3 µM 5.58E-5 59 7.35E-5
17 SGTC_402 epigallocatechin gallate 3.73 10.0 µM 7.46E-5 35 9.73E-5
18 SGTC_1524 corynanthine 3.72 62.1 µM 7.56E-5 23 9.86E-5
19 SGTC_2021 4019055 3.68 173.0 µM 8.93E-5 endomembrane recycling 140 1.16E-4
20 SGTC_140 0062-0056 3.66 502.5 µM 9.65E-5 29 1.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 4.71E-43 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.221 1.71E-38 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.219 1.16E-37 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.209 2.54E-34 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.207 7.66E-34 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.205 2.54E-33 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.203 1.46E-32 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.199 2.00E-31 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.198 6.55E-31 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.194 8.60E-30 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.188 4.58E-28 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.184 6.25E-27 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.182 2.00E-26 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.181 5.40E-26 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.180 5.55E-26 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together