YOR180C / DCI1

Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR180C / DCI1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.29|P-value:6.56E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.35|P-value:5.40E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:6.07|P-value:4.47E-9 ID:SGTC_99|Compound:0109-0120|FD-Score:3.33|P-value:8.91E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.89|P-value:1.26E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.12|P-value:5.14E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:4.03|P-value:7.22E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.65|P-value:2.95E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:5.60|P-value:5.72E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:3.49|P-value:5.14E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.31|P-value:2.41E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:5.09|P-value:7.41E-7 ID:SGTC_918|Compound:glabranin|FD-Score:5.04|P-value:9.63E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:3.66|P-value:2.87E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.76|P-value:1.97E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.95|P-value:9.99E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.66|P-value:1.75E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.45|P-value:5.85E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.60|P-value:3.58E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.20|P-value:3.77E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.35|P-value:2.01E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.64|P-value:3.07E-4 ID:SGTC_1740|Compound:st038286|FD-Score:6.72|P-value:9.16E-11 ID:SGTC_1747|Compound:st037496|FD-Score:4.70|P-value:4.42E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.47|P-value:1.24E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.48|P-value:1.04E-7 ID:SGTC_2007|Compound:4011539|FD-Score:4.41|P-value:1.54E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.87|P-value:1.32E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.36|P-value:8.08E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.78|P-value:1.84E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.52|P-value:4.63E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.61|P-value:3.47E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.44|P-value:6.16E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.86|P-value:1.37E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:4.60|P-value:6.99E-6 ID:SGTC_2707|Compound:st078556|FD-Score:-3.47|P-value:3.51E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.49|P-value:3.29E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.41|P-value:1.55E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.60|P-value:3.53E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.69|P-value:2.61E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.28|P-value:6.81E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.19|P-value:8.90E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.29|P-value:6.56E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.35|P-value:5.40E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:6.07|P-value:4.47E-9 ID:SGTC_99|Compound:0109-0120|FD-Score:3.33|P-value:8.91E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.89|P-value:1.26E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.12|P-value:5.14E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:4.03|P-value:7.22E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.65|P-value:2.95E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:5.60|P-value:5.72E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:3.49|P-value:5.14E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.31|P-value:2.41E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:5.09|P-value:7.41E-7 ID:SGTC_918|Compound:glabranin|FD-Score:5.04|P-value:9.63E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:3.66|P-value:2.87E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.76|P-value:1.97E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.95|P-value:9.99E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.66|P-value:1.75E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.45|P-value:5.85E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.60|P-value:3.58E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.20|P-value:3.77E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.35|P-value:2.01E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.64|P-value:3.07E-4 ID:SGTC_1740|Compound:st038286|FD-Score:6.72|P-value:9.16E-11 ID:SGTC_1747|Compound:st037496|FD-Score:4.70|P-value:4.42E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.47|P-value:1.24E-5 ID:SGTC_1959|Compound:st077091|FD-Score:5.48|P-value:1.04E-7 ID:SGTC_2007|Compound:4011539|FD-Score:4.41|P-value:1.54E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.87|P-value:1.32E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.36|P-value:8.08E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.78|P-value:1.84E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.52|P-value:4.63E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.61|P-value:3.47E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.44|P-value:6.16E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.86|P-value:1.37E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:4.60|P-value:6.99E-6 ID:SGTC_2707|Compound:st078556|FD-Score:-3.47|P-value:3.51E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.49|P-value:3.29E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.41|P-value:1.55E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.60|P-value:3.53E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.69|P-value:2.61E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.28|P-value:6.81E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_3077|Compound:9117319|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.19|P-value:8.90E-4

Top fitness defect scores for YOR180C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1740 st038286 6.72 13.2 µM 9.16E-11 1 9.14E-12
2 SGTC_89 0302-0250 6.07 142.1 µM 4.47E-9 4 6.52E-10
3 SGTC_345 1362-0200 5.60 395.0 µM 5.72E-8 5 1.07E-8
4 SGTC_1959 st077091 5.48 55.8 µM 1.04E-7 RPP1 & pyrimidine depletion 14 2.08E-8
5 SGTC_2754 granisetron 5.41 64.0 µM 1.55E-7 14 3.21E-8
6 SGTC_815 1582-0027 5.09 36.9 µM 7.41E-7 7 1.79E-7
7 SGTC_918 glabranin 5.04 770.7 nM 9.63E-7 9 2.39E-7
8 SGTC_1747 st037496 4.70 66.6 µM 4.42E-6 9 1.28E-6
9 SGTC_2676 harmalol 4.60 100.0 µM 6.99E-6 mitochondrial processes 3 2.11E-6
10 SGTC_1750 st081859 4.47 2.4 µM 1.24E-5 endomembrane recycling 154 3.96E-6
11 SGTC_2007 4011539 4.41 71.8 µM 1.54E-5 cell wall signaling 43 5.05E-6
12 SGTC_1629 st005085 4.35 44.9 µM 2.01E-5 RPP1 & pyrimidine depletion 24 6.76E-6
13 SGTC_474 dl-dihydrosphingosine 4.31 5.0 µM 2.41E-5 19 8.26E-6
14 SGTC_1511 0906-3109 4.20 28.5 µM 3.77E-5 excess fatty acid 38 1.35E-5
15 SGTC_234 nsc-17383 4.12 10.7 µM 5.14E-5 ERG2 22 1.90E-5
16 SGTC_287 k060-0039 4.03 29.6 µM 7.22E-5 11 2.76E-5
17 SGTC_1272 0839-0021 3.95 27.0 µM 9.99E-5 17 3.94E-5
18 SGTC_3077 9117319 3.92 49.5 µM 1.10E-4 19 4.38E-5
19 SGTC_232 clozapine 3.89 119.0 µM 1.26E-4 NEO1 67 5.08E-5
20 SGTC_2085 5307070 3.87 144.1 µM 1.32E-4 superoxide 30 5.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.46E-12 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.114 3.04E-11 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.108 3.82E-10 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.105 9.03E-10 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.105 1.09E-9 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.097 1.81E-8 YPR153W YPR153W hom Putative protein of unknown function
0.096 2.39E-8 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.096 2.76E-8 YDL220C CDC13 het Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.094 5.01E-8 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.085 8.80E-7 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.01E-6 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
0.081 2.53E-6 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.079 4.12E-6 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.077 7.48E-6 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.074 1.98E-5 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31