YOR181W / LAS17

Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR181W / LAS17

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-3.13|P-value:3.44E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.01|P-value:6.32E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-7.01|P-value:1.72E-14 ID:SGTC_152|Compound:4469-0003|FD-Score:3.12|P-value:4.18E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.30|P-value:1.97E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.94|P-value:8.24E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.45|P-value:9.04E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.27|P-value:1.97E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.49|P-value:9.03E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:4.17|P-value:3.84E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:3.15|P-value:3.60E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.38|P-value:1.21E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.31|P-value:1.93E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:6.94|P-value:4.30E-14 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.98|P-value:8.05E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.87|P-value:9.01E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:2.90|P-value:9.36E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.74|P-value:2.98E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:6.86|P-value:8.26E-14 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.41|P-value:1.30E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.88|P-value:1.30E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.25|P-value:2.42E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.26|P-value:2.00E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.09|P-value:3.97E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.74|P-value:3.01E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.89|P-value:1.50E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.78|P-value:2.06E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.80|P-value:2.17E-10 ID:SGTC_1778|Compound:st046819|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.91|P-value:9.06E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.92|P-value:1.29E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.11|P-value:4.33E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.64|P-value:3.90E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.98|P-value:9.59E-6 ID:SGTC_2108|Compound:5365811|FD-Score:4.26|P-value:2.41E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.72|P-value:2.01E-7 ID:SGTC_2428|Compound:5615643|FD-Score:11.10|P-value:1.67E-33 ID:SGTC_2430|Compound:5571206|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.39|P-value:1.20E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-4.07|P-value:5.26E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.43|P-value:1.01E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.20|P-value:3.06E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.60|P-value:5.61E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.32|P-value:1.78E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-7.18|P-value:4.01E-15 ID:SGTC_2691|Compound:st077356|FD-Score:6.30|P-value:6.42E-12 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.35|P-value:1.65E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-5.14|P-value:1.33E-8 ID:SGTC_2780|Compound:5215298|FD-Score:4.40|P-value:1.13E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.04|P-value:5.65E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.24|P-value:2.53E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-11.30|P-value:1.74E-34 ID:SGTC_2926|Compound:9010726|FD-Score:4.15|P-value:4.21E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-3.80|P-value:1.93E-5 ID:SGTC_2935|Compound:9038016|FD-Score:7.02|P-value:2.23E-14 ID:SGTC_2957|Compound:9076800|FD-Score:-3.16|P-value:3.00E-4 ID:SGTC_2959|Compound:9079155|FD-Score:2.96|P-value:7.58E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-2.93|P-value:7.35E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.56|P-value:6.57E-5 ID:SGTC_3175|Compound:9106517|FD-Score:3.85|P-value:1.78E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.13|P-value:3.44E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.01|P-value:6.32E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-7.01|P-value:1.72E-14 ID:SGTC_152|Compound:4469-0003|FD-Score:3.12|P-value:4.18E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.30|P-value:1.97E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.94|P-value:8.24E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.45|P-value:9.04E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.27|P-value:1.97E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.49|P-value:9.03E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:4.17|P-value:3.84E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:3.15|P-value:3.60E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.38|P-value:1.21E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.31|P-value:1.93E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:6.94|P-value:4.30E-14 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.98|P-value:8.05E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.87|P-value:9.01E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:2.90|P-value:9.36E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.74|P-value:2.98E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:6.86|P-value:8.26E-14 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.41|P-value:1.30E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.88|P-value:1.30E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.25|P-value:2.42E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.26|P-value:2.00E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.09|P-value:3.97E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.74|P-value:3.01E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.89|P-value:1.50E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.78|P-value:2.06E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.80|P-value:2.17E-10 ID:SGTC_1778|Compound:st046819|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.91|P-value:9.06E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.92|P-value:1.29E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.11|P-value:4.33E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.64|P-value:3.90E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.98|P-value:9.59E-6 ID:SGTC_2108|Compound:5365811|FD-Score:4.26|P-value:2.41E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.72|P-value:2.01E-7 ID:SGTC_2428|Compound:5615643|FD-Score:11.10|P-value:1.67E-33 ID:SGTC_2430|Compound:5571206|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.39|P-value:1.20E-6 ID:SGTC_2434|Compound:5670830|FD-Score:-4.07|P-value:5.26E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.43|P-value:1.01E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.20|P-value:3.06E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.60|P-value:5.61E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.32|P-value:1.78E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-7.18|P-value:4.01E-15 ID:SGTC_2691|Compound:st077356|FD-Score:6.30|P-value:6.42E-12 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.35|P-value:1.65E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-5.14|P-value:1.33E-8 ID:SGTC_2780|Compound:5215298|FD-Score:4.40|P-value:1.13E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.04|P-value:5.65E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.24|P-value:2.53E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-11.30|P-value:1.74E-34 ID:SGTC_2926|Compound:9010726|FD-Score:4.15|P-value:4.21E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-3.80|P-value:1.93E-5 ID:SGTC_2935|Compound:9038016|FD-Score:7.02|P-value:2.23E-14 ID:SGTC_2957|Compound:9076800|FD-Score:-3.16|P-value:3.00E-4 ID:SGTC_2959|Compound:9079155|FD-Score:2.96|P-value:7.58E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-2.93|P-value:7.35E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.56|P-value:6.57E-5 ID:SGTC_3175|Compound:9106517|FD-Score:3.85|P-value:1.78E-5

Top fitness defect scores for YOR181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2428 5615643 11.10 7.8 µM 1.67E-33 1 3.62E-29 4.85
2 SGTC_2935 9038016 7.02 30.0 µM 2.23E-14 3 1.15E-12 2.37
3 SGTC_780 0109-0199 6.94 192.0 µM 4.30E-14 1 2.02E-12 2.08
4 SGTC_1216 1165-0504 6.86 9.7 µM 8.26E-14 1 3.55E-12 2.81
5 SGTC_2691 st077356 6.30 60.2 µM 6.42E-12 2 1.53E-10 1.04
6 SGTC_1681 tripelennamine 5.80 100.0 µM 2.17E-10 3 3.22E-9 1.45
7 SGTC_2424 5537928 4.72 59.2 µM 2.01E-7 5 1.19E-6 0.48
8 SGTC_2780 5215298 4.40 71.4 µM 1.13E-6 12 5.34E-6 0.13
9 SGTC_2431 5490079 4.39 200.0 µM 1.20E-6 4 5.63E-6 0.23
10 SGTC_2686 alizarin 4.32 95.4 µM 1.78E-6 RPP1 & pyrimidine depletion 8 7.93E-6 0.61
11 SGTC_2108 5365811 4.26 200.0 µM 2.41E-6 3 1.03E-5 0.26
12 SGTC_694 1315-0438 4.17 43.2 µM 3.84E-6 2 1.54E-5 0.19
13 SGTC_2926 9010726 4.15 65.2 µM 4.21E-6 4 1.67E-5 0.09
14 SGTC_2022 5136654 3.98 200.0 µM 9.59E-6 6 3.42E-5 0.13
15 SGTC_1795 st049545 3.92 62.3 µM 1.29E-5 TSC3-RPN4 1 4.43E-5 0.56
16 SGTC_1672 st016598 3.89 6.5 µM 1.50E-5 endomembrane recycling 20 5.06E-5 0.01
17 SGTC_3175 9106517 3.85 49.5 µM 1.78E-5 iron homeostasis 8 5.86E-5 0.14
18 SGTC_1084 voriconazole 3.74 435.0 nM 2.98E-5 azole & statin 13 9.17E-5 0.04
19 SGTC_1574 spiramycin 3.74 23.7 µM 3.01E-5 7 9.25E-5 0.14
20 SGTC_2678 equilin 3.60 100.0 µM 5.61E-5 2 1.59E-4 0.31

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.11E-14 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.125 3.11E-13 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.118 5.85E-12 YMR128W ECM16 het Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
0.115 2.57E-11 YHR068W DYS1 het Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
0.115 2.69E-11 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.112 7.81E-11 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.108 4.11E-10 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.104 1.35E-9 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.102 3.40E-9 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.100 6.52E-9 YCR073C SSK22 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
0.097 1.57E-8 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.097 2.06E-8 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.095 3.28E-8 YML022W APT1 hom Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication
0.094 4.21E-8 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.094 4.68E-8 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication