YOR183W_p / FYV12

Protein of unknown function, required for survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR183W / FYV12

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.15|P-value:2.98E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:4.66|P-value:3.41E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:3.78|P-value:1.27E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:6.87|P-value:1.92E-11 ID:SGTC_439|Compound:amiodarone|FD-Score:6.58|P-value:1.19E-10 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.40|P-value:6.67E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.41|P-value:6.59E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.21|P-value:9.27E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:5.07|P-value:5.02E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:4.06|P-value:4.38E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:3.61|P-value:2.37E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.20|P-value:9.58E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-4.50|P-value:1.05E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:5.42|P-value:8.62E-8 ID:SGTC_881|Compound:0833-0569|FD-Score:4.53|P-value:6.04E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.97|P-value:8.77E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.51|P-value:3.38E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.42|P-value:4.54E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.28|P-value:1.79E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.30|P-value:6.99E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.21|P-value:9.42E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.19|P-value:2.76E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.27|P-value:7.60E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.49|P-value:5.07E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.20|P-value:9.65E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.85|P-value:1.38E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.57|P-value:2.74E-4 ID:SGTC_1810|Compound:st050138|FD-Score:-3.42|P-value:6.39E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.36|P-value:5.59E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.58|P-value:4.88E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.91|P-value:7.91E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.39|P-value:6.92E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.24|P-value:2.05E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-4.90|P-value:1.76E-6 ID:SGTC_2341|Compound:7987486|FD-Score:3.62|P-value:2.30E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.20|P-value:9.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:7.56E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.79|P-value:1.21E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.84|P-value:1.04E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.87|P-value:1.30E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.21|P-value:9.33E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.65|P-value:2.04E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.97|P-value:9.01E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.89|P-value:8.31E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.49|P-value:3.64E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.44|P-value:5.83E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.36|P-value:5.68E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-4.24|P-value:3.07E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-3.47|P-value:5.34E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.15|P-value:2.98E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:4.66|P-value:3.41E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:3.78|P-value:1.27E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:6.87|P-value:1.92E-11 ID:SGTC_439|Compound:amiodarone|FD-Score:6.58|P-value:1.19E-10 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.40|P-value:6.67E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.41|P-value:6.59E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.21|P-value:9.27E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:5.07|P-value:5.02E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:4.06|P-value:4.38E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:3.61|P-value:2.37E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.20|P-value:9.58E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-4.50|P-value:1.05E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:5.42|P-value:8.62E-8 ID:SGTC_881|Compound:0833-0569|FD-Score:4.53|P-value:6.04E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.97|P-value:8.77E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.51|P-value:3.38E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.42|P-value:4.54E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.28|P-value:1.79E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.30|P-value:6.99E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.21|P-value:9.42E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.19|P-value:2.76E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.27|P-value:7.60E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.49|P-value:5.07E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.20|P-value:9.65E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.85|P-value:1.38E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.57|P-value:2.74E-4 ID:SGTC_1810|Compound:st050138|FD-Score:-3.42|P-value:6.39E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.36|P-value:5.59E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.58|P-value:4.88E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.91|P-value:7.91E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.39|P-value:6.92E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.24|P-value:2.05E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-4.90|P-value:1.76E-6 ID:SGTC_2341|Compound:7987486|FD-Score:3.62|P-value:2.30E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.20|P-value:9.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.92|P-value:7.56E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.79|P-value:1.21E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.84|P-value:1.04E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.87|P-value:1.30E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.21|P-value:9.33E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.65|P-value:2.04E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.97|P-value:9.01E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.89|P-value:8.31E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.49|P-value:3.64E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.44|P-value:5.83E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.36|P-value:5.68E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-4.24|P-value:3.07E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-3.47|P-value:5.34E-4

Top fitness defect scores for YOR183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 6.87 24.7 µM 1.92E-11 14 3.21E-12
2 SGTC_439 amiodarone 6.58 34.4 µM 1.19E-10 NEO1-PIK1 37 2.33E-11
3 SGTC_856 0433-0016 5.42 11.3 µM 8.62E-8 3 2.94E-8
4 SGTC_1506 4226-2149 5.19 212.0 µM 2.76E-7 12 1.03E-7
5 SGTC_651 3253-0966 5.07 34.4 µM 5.02E-7 calcium & mitochondrial duress 14 1.98E-7
6 SGTC_175 3793-3120 4.66 23.7 µM 3.41E-6 6 1.57E-6
7 SGTC_1856 st057054 4.58 55.7 µM 4.88E-6 18 2.31E-6
8 SGTC_881 0833-0569 4.53 170.0 µM 6.04E-6 14 2.92E-6
9 SGTC_1074 carmofur 4.28 3.8 µM 1.79E-5 exosome 14 9.45E-6
10 SGTC_2118 5526350 4.24 200.0 µM 2.05E-5 12 1.09E-5
11 SGTC_118 0083-0097 4.15 135.3 µM 2.98E-5 translation 114 1.64E-5
12 SGTC_652 0437-0092 4.06 114.0 µM 4.38E-5 11 2.48E-5
13 SGTC_2688 kanamycin b 3.92 96.7 µM 7.56E-5 calcium & mitochondrial duress 373 4.46E-5
14 SGTC_1874 staurosporine 3.91 7.6 µM 7.91E-5 cell wall signaling 28 4.69E-5
15 SGTC_3199 9111318 3.89 49.5 µM 8.31E-5 23 4.94E-5
16 SGTC_2862 9027634 3.84 71.4 µM 1.04E-4 ERG2 35 6.27E-5
17 SGTC_2730 imipramine 3.79 71.3 µM 1.21E-4 31 7.39E-5
18 SGTC_179 1273-0063 3.78 6.8 µM 1.27E-4 26 7.77E-5
19 SGTC_1135 dihydrocapsaicin 3.73 536.7 nM 1.53E-4 42 9.52E-5
20 SGTC_3154 9100113 3.65 49.5 µM 2.04E-4 39 1.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.57E-14 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.112 6.53E-11 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.104 1.53E-9 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.103 2.28E-9 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.103 2.55E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.100 5.52E-9 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.098 1.41E-8 YAL042C-A_d YAL042C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene
0.097 1.97E-8 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.097 2.10E-8 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.096 2.88E-8 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.094 4.46E-8 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.092 9.27E-8 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.091 1.12E-7 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.091 1.15E-7 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.091 1.28E-7 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases