YOR185C / GSP2

GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR185C / GSP2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.41|P-value:5.74E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.86|P-value:8.23E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:-4.24|P-value:1.85E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:5.41|P-value:1.09E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.44|P-value:3.87E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.66|P-value:1.78E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.25|P-value:7.57E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.25|P-value:9.58E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.26|P-value:9.32E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.16|P-value:9.94E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.03|P-value:5.88E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.62|P-value:2.71E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.45|P-value:5.05E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.38|P-value:6.24E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.25|P-value:9.77E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.00|P-value:4.77E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.29|P-value:6.53E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.39|P-value:1.35E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.25|P-value:9.54E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.76|P-value:1.63E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:6.58|P-value:1.34E-10 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.75|P-value:2.70E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.37|P-value:6.46E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.50|P-value:8.40E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.37|P-value:6.62E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:6.17|P-value:1.66E-9 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.50|P-value:4.18E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.52|P-value:3.95E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.68|P-value:2.17E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.07|P-value:4.98E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.61|P-value:2.85E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.35|P-value:5.30E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.15|P-value:3.57E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.25|P-value:2.40E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.37|P-value:6.51E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.72|P-value:1.93E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.89|P-value:7.50E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.54|P-value:7.04E-6 ID:SGTC_1871|Compound:st057448|FD-Score:5.03|P-value:7.19E-7 ID:SGTC_1920|Compound:st075728|FD-Score:3.53|P-value:3.74E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.97|P-value:7.30E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.62|P-value:2.73E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.33|P-value:7.47E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.40|P-value:5.92E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.71|P-value:1.48E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.14|P-value:3.76E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-3.72|P-value:1.40E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.26|P-value:7.34E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.83|P-value:1.90E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.85|P-value:1.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.55|P-value:2.66E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.75|P-value:1.71E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.50|P-value:3.17E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.84|P-value:1.20E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.20|P-value:8.87E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.31|P-value:8.08E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.35|P-value:1.45E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.62|P-value:2.71E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.96|P-value:1.00E-6 ID:SGTC_2835|Compound:9006588|FD-Score:3.41|P-value:5.67E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.53|P-value:3.77E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.36|P-value:5.17E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.98|P-value:5.31E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.37|P-value:6.54E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.16|P-value:3.93E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.41|P-value:5.74E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.86|P-value:8.23E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:-4.24|P-value:1.85E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:5.41|P-value:1.09E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.44|P-value:3.87E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.66|P-value:1.78E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.25|P-value:7.57E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.25|P-value:9.58E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.26|P-value:9.32E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.16|P-value:9.94E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.03|P-value:5.88E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.62|P-value:2.71E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.45|P-value:5.05E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.38|P-value:6.24E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.25|P-value:9.77E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.00|P-value:4.77E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.29|P-value:6.53E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.39|P-value:1.35E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.25|P-value:9.54E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.76|P-value:1.63E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:6.58|P-value:1.34E-10 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.75|P-value:2.70E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.37|P-value:6.46E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.50|P-value:8.40E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.37|P-value:6.62E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:6.17|P-value:1.66E-9 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.50|P-value:4.18E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.52|P-value:3.95E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.68|P-value:2.17E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.07|P-value:4.98E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.61|P-value:2.85E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.35|P-value:5.30E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.15|P-value:3.57E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.25|P-value:2.40E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.37|P-value:6.51E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.72|P-value:1.93E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.89|P-value:7.50E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.54|P-value:7.04E-6 ID:SGTC_1871|Compound:st057448|FD-Score:5.03|P-value:7.19E-7 ID:SGTC_1920|Compound:st075728|FD-Score:3.53|P-value:3.74E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.97|P-value:7.30E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.62|P-value:2.73E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.33|P-value:7.47E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.40|P-value:5.92E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.71|P-value:1.48E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.14|P-value:3.76E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-3.72|P-value:1.40E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.26|P-value:7.34E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.83|P-value:1.90E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.85|P-value:1.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.55|P-value:2.66E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.75|P-value:1.71E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.50|P-value:3.17E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.84|P-value:1.20E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.20|P-value:8.87E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.31|P-value:8.08E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.35|P-value:1.45E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.62|P-value:2.71E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.96|P-value:1.00E-6 ID:SGTC_2835|Compound:9006588|FD-Score:3.41|P-value:5.67E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.53|P-value:3.77E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.36|P-value:5.17E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.98|P-value:5.31E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.37|P-value:6.54E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.16|P-value:3.93E-7

Top fitness defect scores for YOR185C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1007 4101-0031 6.58 70.0 µM 1.34E-10 1 2.32E-11
2 SGTC_1370 2001-0092 6.17 44.6 µM 1.66E-9 7 3.50E-10
3 SGTC_113 0099-0221 5.41 2.5 µM 1.09E-7 7 3.17E-8
4 SGTC_2713 st079149 5.35 53.4 µM 1.45E-7 7 4.32E-8
5 SGTC_3351 9150312 5.16 21.6 µM 3.93E-7 cell wall 16 1.27E-7
6 SGTC_1871 st057448 5.03 67.3 µM 7.19E-7 6 2.43E-7
7 SGTC_2783 7738165 4.96 71.4 µM 1.00E-6 11 3.48E-7
8 SGTC_2450 5739737 4.83 12.9 µM 1.90E-6 8 6.93E-7
9 SGTC_1054 3429-0080 4.75 167.0 µM 2.70E-6 19 1.01E-6
10 SGTC_1788 fluconazole 4.54 20.0 µM 7.04E-6 azole & statin 52 2.84E-6
11 SGTC_1313 1220-0047 4.50 237.0 µM 8.40E-6 24 3.44E-6
12 SGTC_991 3996-0057 4.39 64.7 µM 1.35E-5 13 5.75E-6
13 SGTC_1731 st035964 4.25 63.0 µM 2.40E-5 22 1.07E-5
14 SGTC_1727 st034309 4.15 9.9 µM 3.57E-5 32 1.64E-5
15 SGTC_2293 7624732 4.14 200.0 µM 3.76E-5 22 1.73E-5
16 SGTC_1456 k015-0012 4.07 13.0 µM 4.98E-5 29 2.35E-5
17 SGTC_574 1315-0397 4.03 40.0 µM 5.88E-5 35 2.81E-5
18 SGTC_1929 genistein trimethyl ether 3.97 50.5 µM 7.30E-5 13 3.54E-5
19 SGTC_2452 5863136 3.85 48.4 µM 1.18E-4 28 5.97E-5
20 SGTC_2553 4-methylesculetin 3.84 85.1 µM 1.20E-4 26 6.08E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.14E-7 YLR180W SAM1 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
0.088 3.46E-7 YJL044C GYP6 hom GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
0.083 1.70E-6 YOR325W_d YOR325W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
0.081 2.56E-6 YPL193W RSA1 hom Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
0.080 3.10E-6 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.080 3.77E-6 YMR316C-A_p YMR316C-A_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W
0.077 8.58E-6 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.075 1.21E-5 YML051W GAL80 hom Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
0.074 1.93E-5 YGR031W IMO32 hom Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
0.067 9.67E-5 YCR014C POL4 hom DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
0.067 9.90E-5 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.066 1.29E-4 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.066 1.31E-4 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.065 1.51E-4 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.064 2.15E-4 YBR026C ETR1 hom 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis