YOR186W_p

Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR186W / YOR186W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.24|P-value:5.73E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.23|P-value:5.95E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.20|P-value:5.31E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-4.33|P-value:6.45E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.59|P-value:1.19E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.42|P-value:2.30E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.64|P-value:1.24E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.78|P-value:5.26E-7 ID:SGTC_926|Compound:2268-1401|FD-Score:3.31|P-value:3.55E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.07|P-value:8.32E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.73|P-value:6.93E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.37|P-value:4.11E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.19|P-value:6.76E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.23|P-value:4.65E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.05|P-value:8.83E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-5.50|P-value:1.41E-8 ID:SGTC_1816|Compound:st051957|FD-Score:8.19|P-value:3.87E-17 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:5.49|P-value:1.05E-8 ID:SGTC_2000|Compound:st075254|FD-Score:-3.13|P-value:8.31E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.30|P-value:4.61E-4 ID:SGTC_2051|Compound:5263410|FD-Score:10.00|P-value:9.39E-25 ID:SGTC_2057|Compound:5236571|FD-Score:-7.68|P-value:4.33E-15 ID:SGTC_2268|Compound:7933382|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.67|P-value:8.62E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-3.13|P-value:8.38E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.46|P-value:2.50E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.61|P-value:5.32E-9 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.32|P-value:4.23E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.59|P-value:1.55E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.17|P-value:7.29E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.75|P-value:6.32E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.22|P-value:4.86E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-4.93|P-value:3.41E-7 ID:SGTC_3317|Compound:9138495|FD-Score:3.71|P-value:7.44E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.33|P-value:4.91E-6 ID:SGTC_3332|Compound:9141069|FD-Score:4.71|P-value:7.81E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.24|P-value:5.73E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.23|P-value:5.95E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.20|P-value:5.31E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-4.33|P-value:6.45E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.59|P-value:1.19E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.42|P-value:2.30E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.64|P-value:1.24E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.78|P-value:5.26E-7 ID:SGTC_926|Compound:2268-1401|FD-Score:3.31|P-value:3.55E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.07|P-value:8.32E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.73|P-value:6.93E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.37|P-value:4.11E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.19|P-value:6.76E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.23|P-value:4.65E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.05|P-value:8.83E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-5.50|P-value:1.41E-8 ID:SGTC_1816|Compound:st051957|FD-Score:8.19|P-value:3.87E-17 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:5.49|P-value:1.05E-8 ID:SGTC_2000|Compound:st075254|FD-Score:-3.13|P-value:8.31E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.30|P-value:4.61E-4 ID:SGTC_2051|Compound:5263410|FD-Score:10.00|P-value:9.39E-25 ID:SGTC_2057|Compound:5236571|FD-Score:-7.68|P-value:4.33E-15 ID:SGTC_2268|Compound:7933382|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.67|P-value:8.62E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-3.13|P-value:8.38E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.46|P-value:2.50E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.61|P-value:5.32E-9 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.32|P-value:4.23E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.59|P-value:1.55E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.17|P-value:7.29E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.75|P-value:6.32E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.22|P-value:4.86E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-4.93|P-value:3.41E-7 ID:SGTC_3317|Compound:9138495|FD-Score:3.71|P-value:7.44E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.33|P-value:4.91E-6 ID:SGTC_3332|Compound:9141069|FD-Score:4.71|P-value:7.81E-7

Top fitness defect scores for YOR186W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2051 5263410 10.00 176.0 µM 9.39E-25 1 5.54E-24
2 SGTC_1816 st051957 8.19 91.6 µM 3.87E-17 1 1.33E-16
3 SGTC_2495 cafestol 5.61 54.5 µM 5.32E-9 Golgi 9 1.01E-8
4 SGTC_1823 3-hydroxy-2-naphthoic acid 5.49 106.0 µM 1.05E-8 3 1.96E-8
5 SGTC_878 0828-0289 4.78 13.7 µM 5.26E-7 27 8.64E-7
6 SGTC_3332 9141069 4.71 11.2 µM 7.81E-7 5 1.27E-6
7 SGTC_1002 4049-0206 4.37 172.0 µM 4.11E-6 21 6.32E-6
8 SGTC_3321 9137793 4.33 26.8 µM 4.91E-6 cell wall 66 7.50E-6
9 SGTC_2979 9012552 3.75 45.5 µM 6.32E-5 12 8.86E-5
10 SGTC_935 2996-0153 3.73 430.0 µM 6.93E-5 PDR1 24 9.69E-5
11 SGTC_3317 9138495 3.71 8.8 µM 7.44E-5 37 1.04E-4
12 SGTC_2400 5203494 3.67 178.7 µM 8.62E-5 RSC complex & mRNA processing 31 1.20E-4
13 SGTC_512 prima-1 3.59 270.0 µM 1.19E-4 DNA intercalators 35 1.63E-4
14 SGTC_2268 7933382 3.57 153.8 µM 1.31E-4 49 1.79E-4
15 SGTC_798 1287-0182 3.42 476.0 µM 2.30E-4 39 3.09E-4
16 SGTC_926 2268-1401 3.31 59.4 µM 3.55E-4 TSC3-RPN4 45 4.70E-4
17 SGTC_1335 1486-0900 3.23 202.0 µM 4.65E-4 63 6.10E-4
18 SGTC_3138 9097216 3.22 49.5 µM 4.86E-4 37 6.37E-4
19 SGTC_3320 9137005 3.22 35.1 µM 4.90E-4 endomembrane recycling 39 6.41E-4
20 SGTC_157 1348-1695 3.20 65.8 µM 5.31E-4 iron homeostasis 119 6.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.19E-20 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.126 2.28E-13 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.083 1.51E-6 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.082 2.10E-6 YPL020C ULP1 het Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
0.081 2.55E-6 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.080 3.04E-6 YDL093W PMT5 hom Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
0.079 4.21E-6 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.79E-6 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.077 8.31E-6 YDR379C-A YDR379C-A hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy
0.074 1.98E-5 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.073 2.28E-5 YDR313C PIB1 hom RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
0.073 2.59E-5 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.070 4.96E-5 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.068 7.53E-5 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.068 7.84E-5 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation