YOR187W / TUF1

Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR187W / TUF1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.27|P-value:4.07E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.50|P-value:1.24E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.40|P-value:2.73E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.04|P-value:3.49E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:7.50|P-value:1.20E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:6.03|P-value:8.95E-7 ID:SGTC_186|Compound:3455-3465|FD-Score:4.17|P-value:5.44E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.30|P-value:1.44E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:4.21|P-value:4.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.74|P-value:1.50E-12 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.39|P-value:2.07E-9 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.94|P-value:4.02E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:8.61|P-value:3.10E-12 ID:SGTC_312|Compound:4092-0653|FD-Score:-6.22|P-value:1.23E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.21|P-value:2.08E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.29|P-value:1.64E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.21|P-value:1.92E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-3.69|P-value:9.40E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.82|P-value:2.85E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.63|P-value:5.37E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-4.21|P-value:2.11E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.01|P-value:8.53E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.38|P-value:2.91E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-5.10|P-value:1.08E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:5.27|P-value:1.56E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.68|P-value:9.80E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.91|P-value:5.54E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.31|P-value:1.51E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-4.20|P-value:2.15E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-4.10|P-value:2.93E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-4.12|P-value:2.71E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:-6.27|P-value:9.82E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:-8.40|P-value:2.16E-12 ID:SGTC_1630|Compound:st005209|FD-Score:-4.28|P-value:1.68E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.74|P-value:8.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.75|P-value:3.62E-5 ID:SGTC_1723|Compound:st034307|FD-Score:4.68|P-value:1.17E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.25|P-value:4.24E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.49|P-value:2.09E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.29|P-value:1.49E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.61|P-value:1.42E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.96|P-value:1.74E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.10|P-value:6.59E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.68|P-value:9.78E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.22|P-value:1.86E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.10|P-value:6.60E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.68|P-value:9.62E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-3.94|P-value:4.61E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.76|P-value:8.85E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.34|P-value:4.31E-6 ID:SGTC_2625|Compound:euphol|FD-Score:-4.02|P-value:3.72E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.27|P-value:1.74E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.49|P-value:8.54E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.04|P-value:2.85E-9 ID:SGTC_2914|Compound:7968218|FD-Score:-3.70|P-value:9.14E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.11|P-value:2.79E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.64|P-value:1.29E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.95|P-value:1.79E-5 ID:SGTC_2969|Compound:9091408|FD-Score:5.91|P-value:1.42E-6 ID:SGTC_2974|Compound:9094440|FD-Score:6.87|P-value:2.33E-8 ID:SGTC_3099|Compound:9120367|FD-Score:4.29|P-value:3.86E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-4.33|P-value:1.41E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.80|P-value:6.97E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.78|P-value:7.29E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.37|P-value:2.99E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.27|P-value:4.07E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.50|P-value:1.24E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.40|P-value:2.73E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.04|P-value:3.49E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:7.50|P-value:1.20E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:6.03|P-value:8.95E-7 ID:SGTC_186|Compound:3455-3465|FD-Score:4.17|P-value:5.44E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.30|P-value:1.44E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:4.21|P-value:4.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.74|P-value:1.50E-12 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.39|P-value:2.07E-9 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.94|P-value:4.02E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:8.61|P-value:3.10E-12 ID:SGTC_312|Compound:4092-0653|FD-Score:-6.22|P-value:1.23E-7 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.21|P-value:2.08E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.29|P-value:1.64E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.21|P-value:1.92E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-3.69|P-value:9.40E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.82|P-value:2.85E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.63|P-value:5.37E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-4.21|P-value:2.11E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.01|P-value:8.53E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.38|P-value:2.91E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-5.10|P-value:1.08E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:5.27|P-value:1.56E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.68|P-value:9.80E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.91|P-value:5.54E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.31|P-value:1.51E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-4.20|P-value:2.15E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-4.10|P-value:2.93E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-4.12|P-value:2.71E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:-6.27|P-value:9.82E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:-8.40|P-value:2.16E-12 ID:SGTC_1630|Compound:st005209|FD-Score:-4.28|P-value:1.68E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.74|P-value:8.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.75|P-value:3.62E-5 ID:SGTC_1723|Compound:st034307|FD-Score:4.68|P-value:1.17E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.25|P-value:4.24E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.49|P-value:2.09E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.29|P-value:1.49E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.61|P-value:1.42E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.96|P-value:1.74E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.10|P-value:6.59E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.68|P-value:9.78E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.22|P-value:1.86E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.10|P-value:6.60E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.68|P-value:9.62E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-3.94|P-value:4.61E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.76|P-value:8.85E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.34|P-value:4.31E-6 ID:SGTC_2625|Compound:euphol|FD-Score:-4.02|P-value:3.72E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.27|P-value:1.74E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.49|P-value:8.54E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.04|P-value:2.85E-9 ID:SGTC_2914|Compound:7968218|FD-Score:-3.70|P-value:9.14E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.11|P-value:2.79E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.64|P-value:1.29E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.95|P-value:1.79E-5 ID:SGTC_2969|Compound:9091408|FD-Score:5.91|P-value:1.42E-6 ID:SGTC_2974|Compound:9094440|FD-Score:6.87|P-value:2.33E-8 ID:SGTC_3099|Compound:9120367|FD-Score:4.29|P-value:3.86E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-4.33|P-value:1.41E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.80|P-value:6.97E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.78|P-value:7.29E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.37|P-value:2.99E-4

Top fitness defect scores for YOR187W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.74 5.3 µM 1.50E-12 228 1.16E-18
2 SGTC_310 1273-0058 8.61 1.1 µM 3.10E-12 mitochondrial stress 72 3.52E-18
3 SGTC_168 3970-0862 7.50 530.5 µM 1.20E-9 23 3.28E-14
4 SGTC_275 trichlorophene 7.39 5.7 µM 2.07E-9 mitochondrial stress 88 7.57E-14
5 SGTC_2974 9094440 6.87 9.7 µM 2.33E-8 ergosterol biosynthesis 4 3.10E-12
6 SGTC_70 0141-0289 6.50 43.3 µM 1.24E-7 mitochondrial stress 67 4.04E-11
7 SGTC_173 1273-0061 6.03 2.7 µM 8.95E-7 mitochondrial stress 107 8.35E-10
8 SGTC_2969 9091408 5.91 28.7 µM 1.42E-6 3 1.69E-9
9 SGTC_195 4234-0266 5.30 16.6 µM 1.44E-5 11 5.94E-8
10 SGTC_1883 5-benzylidenerhodanine 5.29 20.0 µM 1.49E-5 TRP & mitochondrial translation 24 6.25E-8
11 SGTC_830 4076-0286 5.27 57.8 µM 1.56E-5 translation 27 6.68E-8
12 SGTC_2276 7947513 5.22 42.1 µM 1.86E-5 8 8.73E-8
13 SGTC_386 1509-0011 5.21 3.1 µM 1.92E-5 101 9.21E-8
14 SGTC_159 3970-0959 5.04 50.0 µM 3.49E-5 41 2.30E-7
15 SGTC_1154 4088-0362 4.91 150.0 µM 5.54E-5 5 4.67E-7
16 SGTC_2528 xanthyletin 4.76 44.8 µM 8.85E-5 12 9.58E-7
17 SGTC_1723 st034307 4.68 2.5 µM 1.17E-4 mitochondrial processes 15 1.47E-6
18 SGTC_2930 9013230 4.64 14.9 µM 1.29E-4 heme biosynthesis & mitochondrial translocase 18 1.71E-6
19 SGTC_1910 st062352 4.61 60.4 µM 1.42E-4 18 1.98E-6
20 SGTC_1881 5652484 4.49 16.0 µM 2.09E-4 TRP & mitochondrial translation 18 3.57E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.376 3.82E-113 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.367 1.47E-107 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.352 2.57E-98 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.350 1.78E-97 YBR251W MRPS5 hom Mitochondrial ribosomal protein of the small subunit
0.347 1.07E-95 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.342 7.09E-93 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.339 6.48E-91 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.339 7.24E-91 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.337 7.15E-90 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.328 1.16E-84 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.327 1.52E-84 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.326 8.46E-84 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.325 3.35E-83 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.319 1.99E-80 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.319 3.06E-80 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein