YOR188W / MSB1

Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR188W / MSB1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.68|P-value:7.68E-6 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.68|P-value:3.66E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.05|P-value:9.43E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.09|P-value:1.23E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:7.23|P-value:8.43E-12 ID:SGTC_750|Compound:4073-0104|FD-Score:4.40|P-value:2.47E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.37|P-value:5.25E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.47|P-value:7.27E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.94|P-value:1.42E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.79|P-value:2.48E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.89|P-value:1.75E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.14|P-value:6.86E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.53|P-value:1.42E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.87|P-value:8.03E-11 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.05|P-value:9.58E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.86|P-value:1.91E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.19|P-value:5.54E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.57|P-value:5.16E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.61|P-value:4.64E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.41|P-value:8.92E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.06|P-value:1.41E-6 ID:SGTC_1638|Compound:st008370|FD-Score:3.65|P-value:3.95E-4 ID:SGTC_1716|Compound:st033144|FD-Score:11.50|P-value:1.75E-27 ID:SGTC_1718|Compound:roemerine|FD-Score:4.98|P-value:2.02E-6 ID:SGTC_1722|Compound:st034304|FD-Score:7.28|P-value:5.86E-12 ID:SGTC_1808|Compound:st050063|FD-Score:3.61|P-value:4.58E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.60|P-value:4.82E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.53|P-value:5.97E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.51|P-value:6.51E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.92|P-value:1.55E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.18|P-value:5.76E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.71|P-value:3.29E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.95|P-value:1.39E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.80|P-value:2.34E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.27|P-value:7.33E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.86|P-value:9.28E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.84|P-value:9.96E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.61|P-value:4.65E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.05|P-value:9.42E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.84|P-value:9.98E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.35|P-value:3.04E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.74|P-value:2.95E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.70|P-value:3.38E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.75|P-value:2.82E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.89|P-value:1.74E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.59|P-value:1.13E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.86|P-value:1.91E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.13|P-value:6.95E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.99|P-value:1.19E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.30|P-value:6.66E-4 ID:SGTC_3250|Compound:9135583|FD-Score:6.42|P-value:1.22E-9 ID:SGTC_3311|Compound:9131146|FD-Score:7.24|P-value:7.87E-12 ID:SGTC_3325|Compound:9138760|FD-Score:3.93|P-value:1.47E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.68|P-value:7.68E-6 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.68|P-value:3.66E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.05|P-value:9.43E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.09|P-value:1.23E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:7.23|P-value:8.43E-12 ID:SGTC_750|Compound:4073-0104|FD-Score:4.40|P-value:2.47E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.37|P-value:5.25E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.47|P-value:7.27E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.94|P-value:1.42E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.79|P-value:2.48E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.89|P-value:1.75E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.14|P-value:6.86E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.53|P-value:1.42E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.87|P-value:8.03E-11 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.05|P-value:9.58E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.86|P-value:1.91E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.19|P-value:5.54E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.57|P-value:5.16E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.61|P-value:4.64E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.41|P-value:8.92E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.06|P-value:1.41E-6 ID:SGTC_1638|Compound:st008370|FD-Score:3.65|P-value:3.95E-4 ID:SGTC_1716|Compound:st033144|FD-Score:11.50|P-value:1.75E-27 ID:SGTC_1718|Compound:roemerine|FD-Score:4.98|P-value:2.02E-6 ID:SGTC_1722|Compound:st034304|FD-Score:7.28|P-value:5.86E-12 ID:SGTC_1808|Compound:st050063|FD-Score:3.61|P-value:4.58E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.60|P-value:4.82E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.53|P-value:5.97E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.51|P-value:6.51E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.92|P-value:1.55E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.18|P-value:5.76E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.71|P-value:3.29E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.95|P-value:1.39E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.80|P-value:2.34E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.27|P-value:7.33E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.86|P-value:9.28E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.84|P-value:9.96E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.61|P-value:4.65E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.05|P-value:9.42E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.84|P-value:9.98E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.35|P-value:3.04E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.74|P-value:2.95E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.70|P-value:3.38E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.75|P-value:2.82E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.89|P-value:1.74E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.59|P-value:1.13E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.86|P-value:1.91E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.13|P-value:6.95E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.99|P-value:1.19E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.30|P-value:6.66E-4 ID:SGTC_3250|Compound:9135583|FD-Score:6.42|P-value:1.22E-9 ID:SGTC_3311|Compound:9131146|FD-Score:7.24|P-value:7.87E-12 ID:SGTC_3325|Compound:9138760|FD-Score:3.93|P-value:1.47E-4

Top fitness defect scores for YOR188W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1716 st033144 11.50 30.6 µM 1.75E-27 1 4.24E-31
2 SGTC_1722 st034304 7.28 3.6 µM 5.86E-12 mitochondrial processes 2 1.61E-13
3 SGTC_3311 9131146 7.24 2.9 µM 7.87E-12 cell wall 42 2.25E-13
4 SGTC_740 k014-0057 7.23 261.0 µM 8.43E-12 1 2.43E-13
5 SGTC_1229 0139-0193 6.87 12.2 µM 8.03E-11 RSC complex & mRNA processing 1 3.14E-12
6 SGTC_3250 9135583 6.42 49.5 µM 1.22E-9 1 6.89E-11
7 SGTC_546 peri-Naphthalide 5.09 147.0 µM 1.23E-6 DNA damage response 7 1.80E-7
8 SGTC_1625 st003711 5.06 30.1 µM 1.41E-6 calcium & mitochondrial duress 17 2.09E-7
9 SGTC_1718 roemerine 4.98 11.9 µM 2.02E-6 redox potentiating 22 3.15E-7
10 SGTC_49 0717-0965 4.68 32.1 µM 7.68E-6 60S ribosome export 9 1.44E-6
11 SGTC_10 0279-0212 4.60 42.6 µM 1.06E-5 TRP & mitochondrial translation 84 2.08E-6
12 SGTC_3044 9093193 4.59 49.5 µM 1.13E-5 16 2.25E-6
13 SGTC_1228 0124-0032 4.53 52.5 µM 1.42E-5 8 2.90E-6
14 SGTC_750 4073-0104 4.40 132.0 µM 2.47E-5 7 5.46E-6
15 SGTC_2686 alizarin 4.35 95.4 µM 3.04E-5 RPP1 & pyrimidine depletion 23 6.93E-6
16 SGTC_1329 1447-1697 4.19 50.6 µM 5.54E-5 15 1.37E-5
17 SGTC_2044 5102272 4.18 200.0 µM 5.76E-5 5 1.43E-5
18 SGTC_1015 4130-4525 4.14 82.0 µM 6.86E-5 60S ribosome export 18 1.75E-5
19 SGTC_3052 9092717 4.13 49.5 µM 6.95E-5 22 1.78E-5
20 SGTC_2522 biochanin a 4.05 4.9 µM 9.42E-5 RNA pol III & RNase P/MRP 11 2.51E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.24E-17 YPL038W-A_p YPL038W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.132 1.85E-14 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.110 1.57E-10 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.107 4.28E-10 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.103 2.02E-9 YGL177W_d YGL177W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 2.02E-7 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.088 2.88E-7 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.087 4.36E-7 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.087 4.59E-7 YKR006C MRPL13 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.085 8.72E-7 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.084 1.06E-6 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.083 1.48E-6 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.083 1.70E-6 YPR001W CIT3 hom Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
0.081 2.81E-6 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.080 3.81E-6 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth