YOR189W / IES4

Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR189W / IES4

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.22|P-value:9.17E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.21|P-value:9.60E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.40|P-value:1.10E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.12|P-value:4.56E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.45|P-value:5.47E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.69|P-value:2.37E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.47|P-value:4.97E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.91|P-value:8.25E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.21|P-value:2.45E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.31|P-value:7.00E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.75|P-value:1.46E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.63|P-value:2.85E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.63|P-value:2.31E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.02|P-value:6.92E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-4.03|P-value:6.53E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-3.47|P-value:4.98E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.47|P-value:5.08E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.57|P-value:2.82E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.19|P-value:2.69E-5 ID:SGTC_2112|Compound:5488546|FD-Score:5.00|P-value:7.54E-7 ID:SGTC_2145|Compound:5634607|FD-Score:-3.49|P-value:4.68E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.99|P-value:5.89E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.56|P-value:2.92E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.28|P-value:7.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.07|P-value:5.33E-12 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.63|P-value:2.33E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.71|P-value:1.74E-4 ID:SGTC_2860|Compound:9025725|FD-Score:4.12|P-value:3.52E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.44|P-value:5.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.21|P-value:3.67E-7 ID:SGTC_2907|Compound:7721985|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.37|P-value:5.70E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.00|P-value:5.67E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.22|P-value:9.17E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.21|P-value:9.60E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.40|P-value:1.10E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.12|P-value:4.56E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.45|P-value:5.47E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.69|P-value:2.37E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.47|P-value:4.97E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.65|P-value:2.15E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.91|P-value:8.25E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.21|P-value:2.45E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.31|P-value:7.00E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.75|P-value:1.46E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.63|P-value:2.85E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.63|P-value:2.31E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.02|P-value:6.92E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-4.03|P-value:6.53E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-3.47|P-value:4.98E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.47|P-value:5.08E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.57|P-value:2.82E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.19|P-value:2.69E-5 ID:SGTC_2112|Compound:5488546|FD-Score:5.00|P-value:7.54E-7 ID:SGTC_2145|Compound:5634607|FD-Score:-3.49|P-value:4.68E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.99|P-value:5.89E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.56|P-value:2.92E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.28|P-value:7.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.07|P-value:5.33E-12 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.63|P-value:2.33E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.71|P-value:1.74E-4 ID:SGTC_2860|Compound:9025725|FD-Score:4.12|P-value:3.52E-5 ID:SGTC_2864|Compound:9034755|FD-Score:-3.44|P-value:5.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.21|P-value:3.67E-7 ID:SGTC_2907|Compound:7721985|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.37|P-value:5.70E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.00|P-value:5.67E-5

Top fitness defect scores for YOR189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 7.07 100.0 µM 5.33E-12 redox potentiating 126 7.58E-13
2 SGTC_2112 5488546 5.00 200.0 µM 7.54E-7 TSC3-RPN4 8 2.93E-7
3 SGTC_88 0180-0332 4.40 8.7 µM 1.10E-5 14 5.33E-6
4 SGTC_1022 4477-0945 4.21 21.3 µM 2.45E-5 17 1.27E-5
5 SGTC_1923 st058458 4.19 19.1 µM 2.69E-5 27 1.40E-5
6 SGTC_2860 9025725 4.12 39.0 µM 3.52E-5 RPP1 & pyrimidine depletion 7 1.87E-5
7 SGTC_3081 9117243 4.00 49.5 µM 5.67E-5 fatty acid desaturase (OLE1) 18 3.13E-5
8 SGTC_2431 5490079 3.99 200.0 µM 5.89E-5 33 3.26E-5
9 SGTC_968 1309-0633 3.91 340.0 µM 8.25E-5 13 4.70E-5
10 SGTC_200 k038-0079 3.84 37.5 µM 1.06E-4 ubiquinone biosynthesis & proteasome 59 6.12E-5
11 SGTC_1510 1123-0200 3.84 71.5 µM 1.06E-4 47 6.15E-5
12 SGTC_1511 0906-3109 3.75 28.5 µM 1.46E-4 excess fatty acid 57 8.67E-5
13 SGTC_2805 7950783 3.71 58.4 µM 1.74E-4 39 1.05E-4
14 SGTC_2907 7721985 3.68 69.9 µM 1.91E-4 30 1.16E-4
15 SGTC_961 1252-1571 3.65 372.0 µM 2.15E-4 39 1.32E-4
16 SGTC_1705 st027868 3.63 56.3 µM 2.31E-4 15 1.43E-4
17 SGTC_2628 lathosterol 3.63 100.0 µM 2.33E-4 39 1.44E-4
18 SGTC_2167 5876490 3.61 200.0 µM 2.44E-4 42 1.51E-4
19 SGTC_1908 st060353 3.57 56.5 µM 2.82E-4 RPP1 & pyrimidine depletion 55 1.77E-4
20 SGTC_2475 5812728 3.56 15.0 µM 2.92E-4 mitochondrial processes 32 1.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 8.65E-47 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.196 1.90E-30 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.175 1.30E-24 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.171 2.08E-23 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.166 3.61E-22 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.166 4.63E-22 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.160 1.20E-20 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.158 3.72E-20 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.155 1.53E-19 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.153 4.49E-19 YIL018W RPL2B hom Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures
0.149 3.34E-18 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.143 1.12E-16 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.140 4.32E-16 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.139 6.48E-16 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.138 1.11E-15 YHR001W-A QCR10 hom Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain