HIPHOP chemogenomics database

YOR191W / ULS1

Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR191W / ULS1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR191W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_829	1635-0120	23.50	117.0 µM	4.83E-124	DNA damage response	1	5.97E-122
2	SGTC_73	0327-0325	18.40	16.2 µM	1.45E-77	DNA damage response	1	3.26E-76
3	SGTC_3247	9135149	16.80	49.5 µM	1.25E-64	DNA damage response	1	1.73E-63
4	SGTC_2128	5255449	10.70	168.5 µM	1.25E-27		1	4.17E-27
5	SGTC_1707	st032323	10.40	6.3 µM	4.78E-26	DNA damage response	9	1.50E-25
6	SGTC_1859	st055998	9.85	20.0 µM	1.26E-23		1	3.60E-23
7	SGTC_1930	st074634	9.07	34.3 µM	2.30E-20	RNA pol III & RNase P/MRP	4	5.74E-20
8	SGTC_1079	idarubicin	7.20	2.4 µM	1.62E-13	DNA damage response	4	3.04E-13
9	SGTC_997	3996-0078	6.74	137.0 µM	4.37E-12		1	7.72E-12
10	SGTC_238	5hr heat shock (37°C) + nsc-638432	6.63	8.9 µM	9.47E-12	heat shock/prefoldin	13	1.65E-11
11	SGTC_93	0109-0045	5.83	59.2 µM	1.77E-9	DNA damage response	13	2.78E-9
12	SGTC_1047	2043-3044	5.51	82.0 µM	1.17E-8		11	1.77E-8
13	SGTC_2532	xanthone	5.41	78.9 µM	2.05E-8		13	3.08E-8
14	SGTC_2887	9044784	5.38	58.4 µM	2.45E-8	fatty acid desaturase (OLE1)	9	3.66E-8
15	SGTC_3344	9148862	5.19	3.9 µM	7.06E-8		3	1.03E-7
16	SGTC_1048	3161-0300	5.14	24.5 µM	9.38E-8		7	1.37E-7
17	SGTC_1004	4084-0029	5.00	199.0 µM	1.97E-7		6	2.82E-7
18	SGTC_2928	9011484	4.87	9.8 µM	3.95E-7	heme biosynthesis & mitochondrial translocase	19	5.60E-7
19	SGTC_2048	5246248	4.82	200.0 µM	5.08E-7		2	7.16E-7
20	SGTC_580	1123-0028	4.73	41.0 µM	8.00E-7	DNA damage response	14	1.12E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.420	1.47E-143	YDR004W	RAD57	hom	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.415	4.47E-140	YDR076W	RAD55	hom	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.356	1.35E-100	YDL059C	RAD59	hom	Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.329	1.21E-85	YGL175C	SAE2	hom	Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.326	7.90E-84	YGL163C	RAD54	hom	DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.307	5.52E-74	YOL006C	TOP1	hom	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.247	7.55E-48	YER095W	RAD51	hom	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.237	3.49E-44	YDR225W	HTA1	hom	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.236	1.48E-43	YOR116C	RPO31	het	RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.222	1.09E-38	YER165W	PAB1	het	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.217	3.62E-37	YDR075W	PPH3	hom	Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.202	3.75E-32	YBR154C	RPB5	het	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.189	2.40E-28	YFL002C	SPB4	het	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.170	2.78E-23	YMR048W	CSM3	hom	Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.170	4.27E-23	YBR202W	MCM7	het	Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex