YOR192C / THI72

Transporter of thiamine or related compound; shares sequence similarity with Thi7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR192C / THI72

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.16|P-value:9.26E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.39|P-value:4.05E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:5.11|P-value:1.94E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.47|P-value:3.08E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.16|P-value:9.15E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.55|P-value:2.27E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.18|P-value:8.45E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.56|P-value:3.07E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.31|P-value:5.42E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.78|P-value:9.17E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.50|P-value:2.77E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.43|P-value:2.29E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.41|P-value:6.27E-6 ID:SGTC_1602|Compound:st001878|FD-Score:-3.30|P-value:3.77E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.84|P-value:7.21E-5 ID:SGTC_1619|Compound:st003326|FD-Score:-4.60|P-value:1.48E-6 ID:SGTC_1663|Compound:st014140|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.37|P-value:7.41E-6 ID:SGTC_1740|Compound:st038286|FD-Score:4.38|P-value:7.03E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-3.40|P-value:2.61E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.65|P-value:1.98E-6 ID:SGTC_2064|Compound:5220758|FD-Score:-3.22|P-value:4.99E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.37|P-value:4.45E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.86|P-value:4.28E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.69|P-value:8.29E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.86|P-value:6.78E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.78|P-value:9.39E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.91|P-value:5.40E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.53|P-value:2.40E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:5.94E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.49|P-value:2.87E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.93|P-value:5.04E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.38|P-value:2.84E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.46|P-value:5.01E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.22|P-value:7.44E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.83|P-value:7.48E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.24|P-value:7.04E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.07|P-value:2.73E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-3.56|P-value:1.40E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.23|P-value:7.32E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.10|P-value:7.71E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.07|P-value:8.37E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.16|P-value:9.20E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.16|P-value:9.26E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.39|P-value:4.05E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:5.11|P-value:1.94E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.47|P-value:3.08E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.16|P-value:9.15E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.55|P-value:2.27E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.18|P-value:8.45E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.56|P-value:3.07E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.31|P-value:5.42E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.78|P-value:9.17E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.50|P-value:2.77E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.43|P-value:2.29E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.41|P-value:6.27E-6 ID:SGTC_1602|Compound:st001878|FD-Score:-3.30|P-value:3.77E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.84|P-value:7.21E-5 ID:SGTC_1619|Compound:st003326|FD-Score:-4.60|P-value:1.48E-6 ID:SGTC_1663|Compound:st014140|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_1738|Compound:st035555|FD-Score:4.37|P-value:7.41E-6 ID:SGTC_1740|Compound:st038286|FD-Score:4.38|P-value:7.03E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-3.40|P-value:2.61E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.65|P-value:1.98E-6 ID:SGTC_2064|Compound:5220758|FD-Score:-3.22|P-value:4.99E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.37|P-value:4.45E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.86|P-value:4.28E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.69|P-value:8.29E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.86|P-value:6.78E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.78|P-value:9.39E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.91|P-value:5.40E-5 ID:SGTC_2591|Compound:skatole|FD-Score:3.53|P-value:2.40E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:5.94E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.49|P-value:2.87E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.93|P-value:5.04E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.38|P-value:2.84E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.46|P-value:5.01E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.22|P-value:7.44E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.83|P-value:7.48E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.24|P-value:7.04E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.07|P-value:2.73E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-3.56|P-value:1.40E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.23|P-value:7.32E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.10|P-value:7.71E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.07|P-value:8.37E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.16|P-value:9.20E-4

Top fitness defect scores for YOR192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_337 1315-0038 5.11 354.0 µM 1.94E-7 amide catabolism 15 1.60E-7
2 SGTC_1765 st044815 4.65 90.4 µM 1.98E-6 12 1.65E-6
3 SGTC_686 1319-0111 4.56 510.0 µM 3.07E-6 60S ribosome export 16 2.57E-6
4 SGTC_2792 7535235 4.46 81.8 µM 5.01E-6 fatty acid desaturase (OLE1) 24 4.19E-6
5 SGTC_1446 4239-0190 4.41 62.0 µM 6.27E-6 27 5.24E-6
6 SGTC_1740 st038286 4.38 13.2 µM 7.03E-6 18 5.88E-6
7 SGTC_1738 st035555 4.37 74.0 µM 7.41E-6 TSC3-RPN4 22 6.20E-6
8 SGTC_3126 9127922 4.07 49.5 µM 2.73E-5 fatty acid desaturase (OLE1) 31 2.30E-5
9 SGTC_2716 st080858 3.93 38.6 µM 5.04E-5 60S ribosome export 22 4.26E-5
10 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 3.91 13.2 µM 5.40E-5 28 4.57E-5
11 SGTC_2459 5811157 3.86 9.2 µM 6.78E-5 mitochondrial processes 15 5.74E-5
12 SGTC_1606 st000094 3.84 49.2 µM 7.21E-5 60S ribosome export 21 6.10E-5
13 SGTC_2817 7995342 3.83 71.4 µM 7.48E-5 29 6.33E-5
14 SGTC_752 1896-0090 3.78 130.0 µM 9.17E-5 TSC3-RPN4 21 7.78E-5
15 SGTC_2475 5812728 3.78 15.0 µM 9.39E-5 mitochondrial processes 25 7.97E-5
16 SGTC_999 4022-0066 3.76 22.7 µM 1.01E-4 Golgi 54 8.55E-5
17 SGTC_3282 9108498 3.75 15.5 µM 1.05E-4 32 8.91E-5
18 SGTC_1677 st019204 3.75 53.9 µM 1.06E-4 23 8.96E-5
19 SGTC_982 1491-0518 3.72 27.5 µM 1.19E-4 17 1.01E-4
20 SGTC_50 0929-0078 3.57 56.4 µM 2.07E-4 62 1.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.58E-14 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.127 1.41E-13 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.104 1.34E-9 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.102 2.81E-9 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.098 1.27E-8 YOL117W RRI2 hom Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
0.095 4.17E-8 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.094 5.29E-8 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.090 1.92E-7 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.081 2.48E-6 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.078 6.85E-6 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.077 8.71E-6 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.073 2.33E-5 YMR076C PDS5 het Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis
0.072 3.20E-5 YNL290W RFC3 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.070 5.36E-5 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.069 5.83E-5 YOR372C NDD1 het Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes