YOR193W / PEX27

Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR193W / PEX27

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.14|P-value:1.12E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.67|P-value:8.81E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.43|P-value:2.22E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.84|P-value:3.62E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:4.99|P-value:1.67E-7 ID:SGTC_522|Compound:1273-0010|FD-Score:3.27|P-value:4.06E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.14|P-value:6.69E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.82|P-value:4.73E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.65|P-value:9.38E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.35|P-value:3.00E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.21|P-value:4.98E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.38|P-value:2.75E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.93|P-value:2.31E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.15|P-value:6.88E-8 ID:SGTC_1540|Compound:guanosine|FD-Score:3.08|P-value:8.24E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.00|P-value:1.53E-7 ID:SGTC_1746|Compound:st038117|FD-Score:-3.17|P-value:5.80E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.59|P-value:1.28E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.29|P-value:3.66E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.35|P-value:3.08E-4 ID:SGTC_1960|Compound:st011366|FD-Score:5.26|P-value:3.58E-8 ID:SGTC_1961|Compound:st076550|FD-Score:3.11|P-value:7.22E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.44|P-value:2.15E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.20|P-value:5.40E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.12|P-value:1.23E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.69|P-value:8.00E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.23|P-value:4.74E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.01|P-value:2.01E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-4.08|P-value:1.45E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.67|P-value:8.79E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.78|P-value:5.24E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.56|P-value:1.50E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.36|P-value:2.81E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.10|P-value:7.40E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.30|P-value:3.66E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.11|P-value:1.26E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.04|P-value:9.43E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.35|P-value:4.08E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.09|P-value:7.84E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.07|P-value:8.09E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.52|P-value:1.55E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.14|P-value:1.12E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.67|P-value:8.81E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.43|P-value:2.22E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.84|P-value:3.62E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:4.99|P-value:1.67E-7 ID:SGTC_522|Compound:1273-0010|FD-Score:3.27|P-value:4.06E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.14|P-value:6.69E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.82|P-value:4.73E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.65|P-value:9.38E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.35|P-value:3.00E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.21|P-value:4.98E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.38|P-value:2.75E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.93|P-value:2.31E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.15|P-value:6.88E-8 ID:SGTC_1540|Compound:guanosine|FD-Score:3.08|P-value:8.24E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.00|P-value:1.53E-7 ID:SGTC_1746|Compound:st038117|FD-Score:-3.17|P-value:5.80E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.59|P-value:1.28E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.29|P-value:3.66E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.35|P-value:3.08E-4 ID:SGTC_1960|Compound:st011366|FD-Score:5.26|P-value:3.58E-8 ID:SGTC_1961|Compound:st076550|FD-Score:3.11|P-value:7.22E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.44|P-value:2.15E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.20|P-value:5.40E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.12|P-value:1.23E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.29|P-value:3.78E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.69|P-value:8.00E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.23|P-value:4.74E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.01|P-value:2.01E-5 ID:SGTC_2313|Compound:7726885|FD-Score:-4.08|P-value:1.45E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.67|P-value:8.79E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.78|P-value:5.24E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.56|P-value:1.50E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.36|P-value:2.81E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.10|P-value:7.40E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.30|P-value:3.66E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.11|P-value:1.26E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.04|P-value:9.43E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.35|P-value:4.08E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.09|P-value:7.84E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.07|P-value:8.09E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.52|P-value:1.55E-4

Top fitness defect scores for YOR193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1960 st011366 5.26 51.8 µM 3.58E-8 1 7.07E-8
2 SGTC_1456 k015-0012 5.15 13.0 µM 6.88E-8 8 1.32E-7
3 SGTC_1727 st034309 5.00 9.9 µM 1.53E-7 16 2.84E-7
4 SGTC_431 k089-0097 4.99 107.0 µM 1.67E-7 iron homeostasis 14 3.08E-7
5 SGTC_1200 1643-0193 4.93 18.4 µM 2.31E-7 7 4.19E-7
6 SGTC_427 1354-0053 4.84 47.3 µM 3.62E-7 6 6.45E-7
7 SGTC_2628 lathosterol 4.56 100.0 µM 1.50E-6 15 2.52E-6
8 SGTC_1998 st075797 4.12 76.8 µM 1.23E-5 mitochondrial response to ROS 12 1.88E-5
9 SGTC_2211 7117706 4.01 200.0 µM 2.01E-5 10 3.00E-5
10 SGTC_741 4582-0002 3.82 126.0 µM 4.73E-5 13 6.80E-5
11 SGTC_2069 5228469 3.69 200.0 µM 8.00E-5 19 1.12E-4
12 SGTC_2393 9031399 3.67 185.9 µM 8.79E-5 RNA processing & uracil transport 36 1.23E-4
13 SGTC_322 k048-0136 3.67 19.3 µM 8.81E-5 RSC & ERG11 19 1.23E-4
14 SGTC_947 3447-0010 3.65 211.0 µM 9.38E-5 20 1.31E-4
15 SGTC_1783 st039459 3.60 87.5 µM 1.14E-4 Golgi 31 1.58E-4
16 SGTC_3337 9144342 3.52 33.5 µM 1.55E-4 38 2.12E-4
17 SGTC_2956 9076196 3.49 2.5 µM 1.81E-4 35 2.45E-4
18 SGTC_2039 Aminomethylbenzodioxan 3.48 200.0 µM 1.84E-4 11 2.49E-4
19 SGTC_1976 st070609 3.44 63.5 µM 2.15E-4 25 2.89E-4
20 SGTC_1099 5-nonyloxytryptamine 3.38 2.9 µM 2.75E-4 39 3.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 1.01E-12 YIR018C-A_p YIR018C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.100 6.56E-9 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.100 7.52E-9 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.098 1.43E-8 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.66E-8 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.096 2.73E-8 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.091 1.23E-7 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.086 5.71E-7 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.084 1.04E-6 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.084 1.02E-6 YOR306C MCH5 hom Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
0.083 1.58E-6 YAL025C MAK16 het Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
0.080 3.82E-6 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.078 5.85E-6 YLL025W PAU17 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene
0.077 8.05E-6 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.077 8.33E-6 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism