YOR195W / SLK19

Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR195W / SLK19

Click on Significant Values for Screen Details ID:SGTC_304|Compound:1310-0298|FD-Score:3.51|P-value:1.98E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.07|P-value:1.59E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.77|P-value:5.85E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.82|P-value:5.20E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.16|P-value:1.08E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.89|P-value:3.00E-12 ID:SGTC_567|Compound:1080-0542|FD-Score:2.80|P-value:4.97E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:2.89|P-value:3.55E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:2.90|P-value:3.34E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:5.36|P-value:1.91E-10 ID:SGTC_607|Compound:4491-0986|FD-Score:4.34|P-value:1.88E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:3.95|P-value:1.92E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.55|P-value:2.16E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.16|P-value:1.04E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.77|P-value:5.63E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.79|P-value:4.48E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.79|P-value:6.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.92|P-value:3.00E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.70|P-value:7.71E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.75|P-value:6.12E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.25|P-value:4.20E-10 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.18|P-value:9.45E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.00|P-value:2.78E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:2.74|P-value:6.37E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.67|P-value:8.61E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:3.11|P-value:1.33E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.08|P-value:1.55E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.15|P-value:1.41E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.86|P-value:4.03E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.29|P-value:3.22E-10 ID:SGTC_1781|Compound:st038725|FD-Score:3.85|P-value:3.36E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-3.40|P-value:4.37E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.62|P-value:3.20E-8 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.32|P-value:6.49E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.18|P-value:9.57E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.14|P-value:1.18E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.12|P-value:1.25E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.94|P-value:2.86E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.38|P-value:4.82E-14 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.99|P-value:1.49E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:4.38|P-value:1.49E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.77|P-value:5.73E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.23|P-value:3.64E-7 ID:SGTC_3125|Compound:9127534|FD-Score:2.70|P-value:7.63E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.32|P-value:5.07E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-2.89|P-value:4.47E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.35|P-value:4.25E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.63|P-value:1.40E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.41|P-value:1.27E-7 ID:SGTC_3321|Compound:9137793|FD-Score:3.68|P-value:8.24E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:3.51|P-value:1.98E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.07|P-value:1.59E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.77|P-value:5.85E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.82|P-value:5.20E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.16|P-value:1.08E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.89|P-value:3.00E-12 ID:SGTC_567|Compound:1080-0542|FD-Score:2.80|P-value:4.97E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:2.89|P-value:3.55E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:2.90|P-value:3.34E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:5.36|P-value:1.91E-10 ID:SGTC_607|Compound:4491-0986|FD-Score:4.34|P-value:1.88E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:3.95|P-value:1.92E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.55|P-value:2.16E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.16|P-value:1.04E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.77|P-value:5.63E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.79|P-value:4.48E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.79|P-value:6.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.92|P-value:3.00E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.70|P-value:7.71E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.75|P-value:6.12E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.25|P-value:4.20E-10 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.18|P-value:9.45E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.00|P-value:2.78E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:2.74|P-value:6.37E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.67|P-value:8.61E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:3.11|P-value:1.33E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.08|P-value:1.55E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.15|P-value:1.41E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.86|P-value:4.03E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.29|P-value:3.22E-10 ID:SGTC_1781|Compound:st038725|FD-Score:3.85|P-value:3.36E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-3.40|P-value:4.37E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.62|P-value:3.20E-8 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.32|P-value:6.49E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.18|P-value:9.57E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.14|P-value:1.18E-4 ID:SGTC_2262|Compound:9014885|FD-Score:3.12|P-value:1.25E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.94|P-value:2.86E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.38|P-value:4.82E-14 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.99|P-value:1.49E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:4.38|P-value:1.49E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.77|P-value:5.73E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.23|P-value:3.64E-7 ID:SGTC_3125|Compound:9127534|FD-Score:2.70|P-value:7.63E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.32|P-value:5.07E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-2.89|P-value:4.47E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.35|P-value:4.25E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.63|P-value:1.40E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.41|P-value:1.27E-7 ID:SGTC_3321|Compound:9137793|FD-Score:3.68|P-value:8.24E-6

Top fitness defect scores for YOR195W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 6.38 48.7 µM 4.82E-14 cell wall 50 8.98E-11
2 SGTC_514 4466-0038 5.89 2.6 nM 3.00E-12 cell wall 76 1.92E-9
3 SGTC_606 k015-0008 5.36 38.6 µM 1.91E-10 1 4.18E-8
4 SGTC_1758 st042942 5.29 75.2 µM 3.22E-10 6 6.17E-8
5 SGTC_1246 0422-0085 5.25 105.0 µM 4.20E-10 9 7.52E-8
6 SGTC_1911 st060208 4.62 74.3 µM 3.20E-8 19 1.88E-6
7 SGTC_3311 9131146 4.41 2.9 µM 1.27E-7 cell wall 102 5.24E-6
8 SGTC_2606 farnesol 4.38 9.8 µM 1.49E-7 14 5.89E-6
9 SGTC_607 4491-0986 4.34 66.8 µM 1.88E-7 heme requiring 19 7.03E-6
10 SGTC_2610 ononetin 4.23 44.2 µM 3.64E-7 33 1.15E-5
11 SGTC_2595 hexamethylquercetagetin 3.99 100.0 µM 1.49E-6 24 3.27E-5
12 SGTC_608 k048-0125 3.95 159.0 µM 1.92E-6 30 3.96E-5
13 SGTC_1781 st038725 3.85 66.3 µM 3.36E-6 NEO1 105 6.01E-5
14 SGTC_916 4466-0038 3.79 42.0 nM 4.48E-6 cell wall 74 7.44E-5
15 SGTC_3321 9137793 3.68 26.8 µM 8.24E-6 cell wall 84 1.17E-4
16 SGTC_1691 st019933 3.67 84.6 µM 8.61E-6 20 1.21E-4
17 SGTC_304 1310-0298 3.51 97.0 µM 1.98E-5 cell wall 82 2.26E-4
18 SGTC_3195 9113082 3.35 49.5 µM 4.25E-5 31 3.99E-4
19 SGTC_3128 9127691 3.32 49.5 µM 5.07E-5 35 4.55E-4
20 SGTC_1263 0774-1208 3.18 64.8 µM 9.45E-5 93 7.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.357 1.57E-101 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.334 2.52E-88 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.323 2.58E-82 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.276 1.83E-59 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.256 2.49E-51 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.219 1.36E-37 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.216 1.09E-36 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.216 1.21E-36 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.215 2.24E-36 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.212 2.32E-35 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.209 2.06E-34 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.208 3.15E-34 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.203 1.48E-32 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.203 1.76E-32 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.198 4.39E-31 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair