YOR196C / LIP5

Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR196C / LIP5

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:4.24|P-value:4.28E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.30|P-value:4.62E-7 ID:SGTC_54|Compound:0159-0055|FD-Score:8.17|P-value:1.91E-14 ID:SGTC_59|Compound:0330-0160|FD-Score:10.50|P-value:1.16E-22 ID:SGTC_64|Compound:000l-0018|FD-Score:6.19|P-value:4.86E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:7.00|P-value:4.44E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:8.25|P-value:1.02E-14 ID:SGTC_134|Compound:0269-0018|FD-Score:4.03|P-value:9.68E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:4.41|P-value:2.27E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:3.62|P-value:4.05E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:7.34|P-value:5.38E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:3.42|P-value:7.68E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.78|P-value:2.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.53|P-value:1.55E-7 ID:SGTC_228|Compound:caffeine|FD-Score:3.41|P-value:8.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.80|P-value:2.34E-43 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.67|P-value:7.69E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:5.42|P-value:2.66E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:3.49|P-value:6.28E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.21|P-value:6.98E-7 ID:SGTC_504|Compound:lovastatin|FD-Score:3.50|P-value:6.04E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.92|P-value:1.42E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.48|P-value:1.72E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.27|P-value:3.82E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.87|P-value:2.74E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:3.90|P-value:1.56E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:6.47|P-value:1.02E-9 ID:SGTC_724|Compound:3910-0327|FD-Score:4.39|P-value:2.40E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.74|P-value:2.69E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.73|P-value:2.65E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:7.12|P-value:2.18E-11 ID:SGTC_994|Compound:3910-0338|FD-Score:3.57|P-value:4.76E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.22|P-value:4.74E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.83|P-value:1.85E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.87|P-value:1.69E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.07|P-value:8.39E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.87|P-value:3.23E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:3.35|P-value:9.71E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.35|P-value:9.82E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-4.32|P-value:2.99E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.89|P-value:1.60E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:6.72|P-value:2.38E-10 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.42|P-value:7.71E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.42|P-value:7.19E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.80|P-value:4.39E-6 ID:SGTC_1633|Compound:st005664|FD-Score:3.36|P-value:9.52E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.34|P-value:2.46E-18 ID:SGTC_1638|Compound:st008370|FD-Score:4.00|P-value:1.08E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.87|P-value:1.70E-4 ID:SGTC_1696|Compound:st025591|FD-Score:6.34|P-value:2.14E-9 ID:SGTC_1720|Compound:st037298|FD-Score:3.94|P-value:1.35E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.85|P-value:1.85E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-3.43|P-value:7.07E-4 ID:SGTC_2029|Compound:5175081|FD-Score:4.17|P-value:5.69E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.70|P-value:3.10E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.34|P-value:9.50E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.46|P-value:6.49E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.37|P-value:8.66E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.37|P-value:9.27E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.35|P-value:2.79E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.36|P-value:9.58E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:7.28|P-value:7.48E-12 ID:SGTC_2703|Compound:st077852|FD-Score:3.98|P-value:1.16E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.28|P-value:5.07E-7 ID:SGTC_2789|Compound:5281112|FD-Score:3.66|P-value:3.53E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.84|P-value:1.93E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.79|P-value:2.30E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.50|P-value:1.73E-7 ID:SGTC_2974|Compound:9094440|FD-Score:3.78|P-value:2.33E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.39|P-value:2.47E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:4.24|P-value:4.28E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:5.30|P-value:4.62E-7 ID:SGTC_54|Compound:0159-0055|FD-Score:8.17|P-value:1.91E-14 ID:SGTC_59|Compound:0330-0160|FD-Score:10.50|P-value:1.16E-22 ID:SGTC_64|Compound:000l-0018|FD-Score:6.19|P-value:4.86E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:7.00|P-value:4.44E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:8.25|P-value:1.02E-14 ID:SGTC_134|Compound:0269-0018|FD-Score:4.03|P-value:9.68E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:4.41|P-value:2.27E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:3.62|P-value:4.05E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:7.34|P-value:5.38E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:3.42|P-value:7.68E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.78|P-value:2.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.53|P-value:1.55E-7 ID:SGTC_228|Compound:caffeine|FD-Score:3.41|P-value:8.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.80|P-value:2.34E-43 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.67|P-value:7.69E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:5.42|P-value:2.66E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:3.49|P-value:6.28E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.21|P-value:6.98E-7 ID:SGTC_504|Compound:lovastatin|FD-Score:3.50|P-value:6.04E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.92|P-value:1.42E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.48|P-value:1.72E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.27|P-value:3.82E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.87|P-value:2.74E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:3.90|P-value:1.56E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:6.47|P-value:1.02E-9 ID:SGTC_724|Compound:3910-0327|FD-Score:4.39|P-value:2.40E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.74|P-value:2.69E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.73|P-value:2.65E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:7.12|P-value:2.18E-11 ID:SGTC_994|Compound:3910-0338|FD-Score:3.57|P-value:4.76E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.22|P-value:4.74E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.83|P-value:1.85E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.87|P-value:1.69E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.07|P-value:8.39E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.87|P-value:3.23E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:3.35|P-value:9.71E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.35|P-value:9.82E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-4.32|P-value:2.99E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.89|P-value:1.60E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:6.72|P-value:2.38E-10 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.42|P-value:7.71E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.42|P-value:7.19E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.80|P-value:4.39E-6 ID:SGTC_1633|Compound:st005664|FD-Score:3.36|P-value:9.52E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.34|P-value:2.46E-18 ID:SGTC_1638|Compound:st008370|FD-Score:4.00|P-value:1.08E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.87|P-value:1.70E-4 ID:SGTC_1696|Compound:st025591|FD-Score:6.34|P-value:2.14E-9 ID:SGTC_1720|Compound:st037298|FD-Score:3.94|P-value:1.35E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.85|P-value:1.85E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-3.43|P-value:7.07E-4 ID:SGTC_2029|Compound:5175081|FD-Score:4.17|P-value:5.69E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.70|P-value:3.10E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.34|P-value:9.50E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.46|P-value:6.49E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.37|P-value:8.66E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.37|P-value:9.27E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.35|P-value:2.79E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.36|P-value:9.58E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:7.28|P-value:7.48E-12 ID:SGTC_2703|Compound:st077852|FD-Score:3.98|P-value:1.16E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.28|P-value:5.07E-7 ID:SGTC_2789|Compound:5281112|FD-Score:3.66|P-value:3.53E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.84|P-value:1.93E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.79|P-value:2.30E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.50|P-value:1.73E-7 ID:SGTC_2974|Compound:9094440|FD-Score:3.78|P-value:2.33E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.39|P-value:2.47E-5

Top fitness defect scores for YOR196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.80 5.3 µM 2.34E-43 102 4.12E-50
2 SGTC_59 0330-0160 10.50 1.3 µM 1.16E-22 8 4.53E-26
3 SGTC_1635 st007035 9.34 42.4 µM 2.46E-18 82 4.81E-21
4 SGTC_116 0155-0182 8.25 31.8 µM 1.02E-14 mitochondrial response to ROS 9 7.63E-17
5 SGTC_54 0159-0055 8.17 9.0 µM 1.91E-14 ERG2 13 1.58E-16
6 SGTC_142 0335-0849 7.34 62.7 µM 5.38E-12 ubiquinone biosynthesis & proteasome 46 1.10E-13
7 SGTC_2588 indole-3-carbinol 7.28 100.0 µM 7.48E-12 7 1.61E-13
8 SGTC_902 1120-0002 7.12 2.1 µM 2.18E-11 azole & statin 12 5.59E-13
9 SGTC_86 0417-1630 7.00 471.9 µM 4.44E-11 ubiquinone biosynthesis & proteasome 71 1.27E-12
10 SGTC_1381 2324-0066 6.72 62.1 µM 2.38E-10 5 8.92E-12
11 SGTC_708 3448-5400 6.47 146.0 µM 1.02E-9 8 4.80E-11
12 SGTC_1696 st025591 6.34 34.8 µM 2.14E-9 SWF1 & branched chain AA biosynthesis 10 1.14E-10
13 SGTC_64 000l-0018 6.19 272.1 µM 4.86E-9 ubiquinone biosynthesis & proteasome 76 2.95E-10
14 SGTC_691 1548-0686 5.87 185.0 µM 2.74E-8 5 2.19E-9
15 SGTC_173 1273-0061 5.53 2.7 µM 1.55E-7 mitochondrial stress 122 1.64E-8
16 SGTC_2966 9084041 5.50 48.0 µM 1.73E-7 10 1.85E-8
17 SGTC_279 1273-0055 5.42 2.9 µM 2.66E-7 azole & statin 19 3.05E-8
18 SGTC_36 0335-0881 5.30 14.2 µM 4.62E-7 ubiquinone biosynthesis & proteasome 78 5.79E-8
19 SGTC_2765 myclobutanil 5.28 7.7 µM 5.07E-7 azole & statin 20 6.44E-8
20 SGTC_386 1509-0011 5.21 3.1 µM 6.98E-7 102 9.34E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.451 1.43E-167 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.435 2.88E-155 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.415 5.09E-140 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.409 1.10E-135 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.393 4.14E-124 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.389 1.06E-121 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.383 1.47E-117 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.381 1.19E-116 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.372 1.40E-110 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.371 3.45E-110 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.370 1.59E-109 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.370 2.28E-109 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.365 2.03E-106 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.364 1.07E-105 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.361 6.57E-104 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex