YOR198C / BFR1

Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR198C / BFR1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.29|P-value:3.64E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:3.75|P-value:2.45E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.49|P-value:6.03E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.64|P-value:3.59E-13 ID:SGTC_117|Compound:lucigenin|FD-Score:4.87|P-value:2.65E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:8.37|P-value:1.82E-15 ID:SGTC_146|Compound:3448-8650|FD-Score:3.37|P-value:8.95E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.82|P-value:1.92E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.86|P-value:2.81E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:6.81|P-value:8.16E-11 ID:SGTC_309|Compound:k408-0051|FD-Score:5.73|P-value:4.06E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.85|P-value:1.46E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.63|P-value:3.67E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.55|P-value:9.99E-8 ID:SGTC_517|Compound:1365-0151|FD-Score:3.71|P-value:2.78E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.85|P-value:1.70E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:5.14|P-value:7.83E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:4.90|P-value:2.33E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:3.65|P-value:3.49E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.35|P-value:9.35E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.34|P-value:2.87E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.78|P-value:2.15E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:7.12|P-value:1.12E-11 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.78|P-value:2.19E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.47|P-value:6.25E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.15|P-value:7.39E-7 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.60|P-value:4.14E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.34|P-value:9.62E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.38|P-value:8.51E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.32|P-value:2.78E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.51|P-value:3.36E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.22|P-value:8.95E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.54|P-value:5.08E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.55|P-value:4.84E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.53|P-value:4.42E-10 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.27|P-value:4.18E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.74|P-value:2.49E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.52|P-value:1.23E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.58|P-value:9.47E-6 ID:SGTC_1750|Compound:st081859|FD-Score:3.91|P-value:1.34E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.36|P-value:9.08E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.70|P-value:5.68E-6 ID:SGTC_1795|Compound:st049545|FD-Score:-4.05|P-value:4.56E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.32|P-value:2.77E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.35|P-value:9.47E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.48|P-value:1.43E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.76|P-value:2.36E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.27|P-value:3.41E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.17|P-value:5.12E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.53|P-value:3.17E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.76|P-value:1.36E-4 ID:SGTC_2172|Compound:5754775|FD-Score:5.00|P-value:1.48E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.83|P-value:2.32E-8 ID:SGTC_2293|Compound:7624732|FD-Score:4.04|P-value:8.44E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.39|P-value:8.36E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.76|P-value:4.29E-6 ID:SGTC_2402|Compound:5553605|FD-Score:3.33|P-value:9.89E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.59|P-value:4.26E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.64|P-value:3.52E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.72|P-value:5.27E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.73|P-value:2.60E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.61|P-value:8.35E-6 ID:SGTC_2811|Compound:7967822|FD-Score:4.17|P-value:4.99E-5 ID:SGTC_2818|Compound:7996756|FD-Score:4.32|P-value:2.84E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-4.94|P-value:9.78E-7 ID:SGTC_2820|Compound:7989630|FD-Score:4.07|P-value:7.52E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.83|P-value:1.07E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.70|P-value:2.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.74|P-value:1.46E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.37|P-value:8.90E-4 ID:SGTC_3020|Compound:9089140|FD-Score:6.20|P-value:3.09E-9 ID:SGTC_3033|Compound:9090887|FD-Score:5.60|P-value:7.77E-8 ID:SGTC_3100|Compound:9120536|FD-Score:-4.65|P-value:3.69E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-5.02|P-value:6.77E-7 ID:SGTC_3216|Compound:9129716|FD-Score:4.60|P-value:8.84E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.83|P-value:1.81E-4 ID:SGTC_3248|Compound:9135562|FD-Score:4.02|P-value:9.21E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.08|P-value:7.09E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:5.29|P-value:3.64E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:3.75|P-value:2.45E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.49|P-value:6.03E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.64|P-value:3.59E-13 ID:SGTC_117|Compound:lucigenin|FD-Score:4.87|P-value:2.65E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:8.37|P-value:1.82E-15 ID:SGTC_146|Compound:3448-8650|FD-Score:3.37|P-value:8.95E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.82|P-value:1.92E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.86|P-value:2.81E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:6.81|P-value:8.16E-11 ID:SGTC_309|Compound:k408-0051|FD-Score:5.73|P-value:4.06E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.85|P-value:1.46E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.63|P-value:3.67E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.55|P-value:9.99E-8 ID:SGTC_517|Compound:1365-0151|FD-Score:3.71|P-value:2.78E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.85|P-value:1.70E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:5.14|P-value:7.83E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:4.90|P-value:2.33E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:3.65|P-value:3.49E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.35|P-value:9.35E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.34|P-value:2.87E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.78|P-value:2.15E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:7.12|P-value:1.12E-11 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.78|P-value:2.19E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.47|P-value:6.25E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.15|P-value:7.39E-7 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.60|P-value:4.14E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.34|P-value:9.62E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.38|P-value:8.51E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.32|P-value:2.78E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.51|P-value:3.36E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.22|P-value:8.95E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.54|P-value:5.08E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.55|P-value:4.84E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.53|P-value:4.42E-10 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.27|P-value:4.18E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.74|P-value:2.49E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.52|P-value:1.23E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.58|P-value:9.47E-6 ID:SGTC_1750|Compound:st081859|FD-Score:3.91|P-value:1.34E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.36|P-value:9.08E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.70|P-value:5.68E-6 ID:SGTC_1795|Compound:st049545|FD-Score:-4.05|P-value:4.56E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.32|P-value:2.77E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.35|P-value:9.47E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.48|P-value:1.43E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.76|P-value:2.36E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.27|P-value:3.41E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.17|P-value:5.12E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.53|P-value:3.17E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.76|P-value:1.36E-4 ID:SGTC_2172|Compound:5754775|FD-Score:5.00|P-value:1.48E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.83|P-value:2.32E-8 ID:SGTC_2293|Compound:7624732|FD-Score:4.04|P-value:8.44E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.39|P-value:8.36E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.76|P-value:4.29E-6 ID:SGTC_2402|Compound:5553605|FD-Score:3.33|P-value:9.89E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.59|P-value:4.26E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.64|P-value:3.52E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.72|P-value:5.27E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.73|P-value:2.60E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.61|P-value:8.35E-6 ID:SGTC_2811|Compound:7967822|FD-Score:4.17|P-value:4.99E-5 ID:SGTC_2818|Compound:7996756|FD-Score:4.32|P-value:2.84E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-4.94|P-value:9.78E-7 ID:SGTC_2820|Compound:7989630|FD-Score:4.07|P-value:7.52E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.83|P-value:1.07E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.70|P-value:2.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.74|P-value:1.46E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.37|P-value:8.90E-4 ID:SGTC_3020|Compound:9089140|FD-Score:6.20|P-value:3.09E-9 ID:SGTC_3033|Compound:9090887|FD-Score:5.60|P-value:7.77E-8 ID:SGTC_3100|Compound:9120536|FD-Score:-4.65|P-value:3.69E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-5.02|P-value:6.77E-7 ID:SGTC_3216|Compound:9129716|FD-Score:4.60|P-value:8.84E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.83|P-value:1.81E-4 ID:SGTC_3248|Compound:9135562|FD-Score:4.02|P-value:9.21E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.08|P-value:7.09E-5

Top fitness defect scores for YOR198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 8.37 40.9 µM 1.82E-15 cell wall 59 3.01E-17
2 SGTC_58 0957-0393 7.64 9.0 µM 3.59E-13 cell wall 137 1.11E-14
3 SGTC_1105 epirubicin 7.12 18.1 µM 1.12E-11 anthracycline transcription coupled DNA repair 1 5.26E-13
4 SGTC_301 4119-0100 6.81 24.5 µM 8.16E-11 NEO1 33 4.84E-12
5 SGTC_1514 1189-1591 6.53 158.0 µM 4.42E-10 9 3.21E-11
6 SGTC_3020 9089140 6.20 49.5 µM 3.09E-9 4 2.84E-10
7 SGTC_2250 alverine citrate 5.83 130.0 µM 2.32E-8 57 2.72E-9
8 SGTC_309 k408-0051 5.73 1.5 µM 4.06E-8 14 5.09E-9
9 SGTC_3033 9090887 5.60 49.5 µM 7.77E-8 fatty acid desaturase (OLE1) 5 1.05E-8
10 SGTC_467 ro 31-8220 5.55 72.8 µM 9.99E-8 calcium & mitochondrial duress 34 1.40E-8
11 SGTC_1013 4112-3890 5.34 241.0 µM 2.87E-7 TSC3-RPN4 12 4.57E-8
12 SGTC_7 0192-1582 5.29 4.2 µM 3.64E-7 32 5.97E-8
13 SGTC_1580 hydrocortisone 21-hemisuccinate 5.27 43.2 µM 4.18E-7 5 6.95E-8
14 SGTC_1267 0828-0272 5.15 9.5 µM 7.39E-7 7 1.32E-7
15 SGTC_579 4491-1009 5.14 110.0 µM 7.83E-7 60S ribosome export 6 1.41E-7
16 SGTC_2172 5754775 5.00 163.9 µM 1.48E-6 7 2.88E-7
17 SGTC_581 0958-0271 4.90 211.0 µM 2.33E-6 27 4.79E-7
18 SGTC_117 lucigenin 4.87 22.1 µM 2.65E-6 redox potentiating 62 5.53E-7
19 SGTC_221 trifluoperazine 4.86 10.3 µM 2.81E-6 NEO1-PIK1 168 5.89E-7
20 SGTC_2391 6285546 4.76 200.0 µM 4.29E-6 5 9.48E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 3.15E-33 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.196 2.63E-30 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.192 2.77E-29 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.192 3.92E-29 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.191 5.79E-29 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.189 1.78E-28 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.186 1.96E-27 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.185 3.00E-27 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.181 4.79E-26 YGR057C LST7 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.179 1.21E-25 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.178 2.43E-25 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.177 5.71E-25 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.175 1.52E-24 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.175 2.05E-24 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.173 5.37E-24 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication