YOR199W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR199W / YOR199W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.76|P-value:2.22E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.13|P-value:5.51E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:-6.15|P-value:2.46E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.53|P-value:3.67E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.37|P-value:8.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.04|P-value:1.12E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:3.67|P-value:2.99E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.62|P-value:4.34E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:3.70|P-value:2.70E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.34|P-value:8.91E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.62|P-value:3.59E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.07|P-value:5.07E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.52|P-value:1.16E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.58|P-value:4.10E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.39|P-value:5.84E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-4.51|P-value:8.47E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.74|P-value:2.32E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-4.13|P-value:4.04E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-4.32|P-value:1.91E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.39|P-value:5.84E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.67|P-value:3.04E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.80|P-value:3.41E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:6.63|P-value:2.30E-10 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.72|P-value:2.53E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.29|P-value:2.96E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-5.18|P-value:3.95E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.53|P-value:3.75E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.73|P-value:1.86E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.20|P-value:1.85E-9 ID:SGTC_2913|Compound:7966556|FD-Score:-3.43|P-value:5.20E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.40|P-value:5.75E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.64|P-value:2.54E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.48|P-value:1.36E-5 ID:SGTC_3139|Compound:9095020|FD-Score:-3.29|P-value:8.19E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-5.11|P-value:5.58E-7 ID:SGTC_3174|Compound:9107204|FD-Score:-3.56|P-value:3.28E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.83|P-value:1.67E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.76|P-value:2.22E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.13|P-value:5.51E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:-6.15|P-value:2.46E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.53|P-value:3.67E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.37|P-value:8.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.04|P-value:1.12E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:3.67|P-value:2.99E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.62|P-value:4.34E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:3.70|P-value:2.70E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.34|P-value:8.91E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.62|P-value:3.59E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.07|P-value:5.07E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.52|P-value:1.16E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.58|P-value:4.10E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.39|P-value:5.84E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-4.51|P-value:8.47E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.74|P-value:2.32E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-4.13|P-value:4.04E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-4.32|P-value:1.91E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.39|P-value:5.84E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.67|P-value:3.04E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.80|P-value:3.41E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:6.63|P-value:2.30E-10 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.72|P-value:2.53E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.29|P-value:2.96E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-5.18|P-value:3.95E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.53|P-value:3.75E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.73|P-value:1.86E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.20|P-value:1.85E-9 ID:SGTC_2913|Compound:7966556|FD-Score:-3.43|P-value:5.20E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.40|P-value:5.75E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.64|P-value:2.54E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.48|P-value:1.36E-5 ID:SGTC_3139|Compound:9095020|FD-Score:-3.29|P-value:8.19E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-5.11|P-value:5.58E-7 ID:SGTC_3174|Compound:9107204|FD-Score:-3.56|P-value:3.28E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.83|P-value:1.67E-4

Top fitness defect scores for YOR199W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2553 4-methylesculetin 6.63 85.1 µM 2.30E-10 3 1.66E-11
2 SGTC_310 1273-0058 5.04 1.1 µM 1.12E-6 mitochondrial stress 181 2.28E-7
3 SGTC_2451 5856223 4.80 45.7 µM 3.41E-6 10 8.00E-7
4 SGTC_867 0518-0118 4.52 155.0 µM 1.16E-5 DNA intercalators 13 3.16E-6
5 SGTC_3132 9126706 4.48 49.5 µM 1.36E-5 11 3.78E-6
6 SGTC_2638 epoxomicin 4.29 18.0 µM 2.96E-5 23 9.02E-6
7 SGTC_68 0986-0284 4.13 82.8 µM 5.51E-5 64 1.82E-5
8 SGTC_3300 9124615 3.83 50.5 µM 1.67E-4 19 6.32E-5
9 SGTC_58 0957-0393 3.76 9.0 µM 2.22E-4 cell wall 393 8.66E-5
10 SGTC_2074 5212007 3.74 75.4 µM 2.32E-4 16 9.10E-5
11 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.72 100.0 µM 2.53E-4 30 1.00E-4
12 SGTC_601 0986-0029 3.70 62.9 µM 2.70E-4 calcium & mitochondrial duress 44 1.08E-4
13 SGTC_370 0180-0345 3.67 38.7 µM 2.99E-4 DNA intercalators 15 1.21E-4
14 SGTC_2361 9034121 3.67 116.0 µM 3.04E-4 RSC complex & mRNA processing 25 1.24E-4
15 SGTC_820 1582-0060 3.62 59.9 µM 3.59E-4 43 1.49E-4
16 SGTC_1259 0671-0132 3.58 43.0 µM 4.10E-4 36 1.73E-4
17 SGTC_184 1494-0393 3.37 24.7 µM 8.17E-4 89 3.75E-4
18 SGTC_818 4072-2707 3.34 53.5 µM 8.91E-4 30 4.13E-4
19 SGTC_2576 guaiol 3.29 23.1 µM 0.00107 56 5.06E-4
20 SGTC_330 1488-0319 3.21 80.1 µM 0.00136 RPP1 & pyrimidine depletion 35 6.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.89E-48 YPR116W RRG8 hom Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.210 1.12E-34 YLR139C SLS1 hom Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.199 2.12E-31 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.180 8.91E-26 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.179 1.50E-25 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.167 1.91E-22 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.164 1.16E-21 YDR405W MRP20 hom Mitochondrial ribosomal protein of the large subunit
0.163 2.90E-21 YHR011W DIA4 hom Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
0.159 2.06E-20 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.159 1.86E-20 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.158 2.87E-20 YDL044C MTF2 hom Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
0.156 1.21E-19 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.155 1.66E-19 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
0.155 2.23E-19 YLL027W ISA1 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.155 2.19E-19 YBL038W MRPL16 hom Mitochondrial ribosomal protein of the large subunit