HIPHOP chemogenomics database

YOR199W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR199W / YOR199W

Click on Significant Values for Screen Details

Top fitness defect scores for YOR199W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2553	4-methylesculetin	6.63	85.1 µM	2.30E-10		3	1.66E-11
2	SGTC_310	1273-0058	5.04	1.1 µM	1.12E-6	mitochondrial stress	181	2.28E-7
3	SGTC_2451	5856223	4.80	45.7 µM	3.41E-6		10	8.00E-7
4	SGTC_867	0518-0118	4.52	155.0 µM	1.16E-5	DNA intercalators	13	3.16E-6
5	SGTC_3132	9126706	4.48	49.5 µM	1.36E-5		11	3.78E-6
6	SGTC_2638	epoxomicin	4.29	18.0 µM	2.96E-5		23	9.02E-6
7	SGTC_68	0986-0284	4.13	82.8 µM	5.51E-5		64	1.82E-5
8	SGTC_3300	9124615	3.83	50.5 µM	1.67E-4		19	6.32E-5
9	SGTC_58	0957-0393	3.76	9.0 µM	2.22E-4	cell wall	393	8.66E-5
10	SGTC_2074	5212007	3.74	75.4 µM	2.32E-4		16	9.10E-5
11	SGTC_2637	3-alpha-acetoxydihydrodeoxygedunin	3.72	100.0 µM	2.53E-4		30	1.00E-4
12	SGTC_601	0986-0029	3.70	62.9 µM	2.70E-4	calcium & mitochondrial duress	44	1.08E-4
13	SGTC_370	0180-0345	3.67	38.7 µM	2.99E-4	DNA intercalators	15	1.21E-4
14	SGTC_2361	9034121	3.67	116.0 µM	3.04E-4	RSC complex & mRNA processing	25	1.24E-4
15	SGTC_820	1582-0060	3.62	59.9 µM	3.59E-4		43	1.49E-4
16	SGTC_1259	0671-0132	3.58	43.0 µM	4.10E-4		36	1.73E-4
17	SGTC_184	1494-0393	3.37	24.7 µM	8.17E-4		89	3.75E-4
18	SGTC_818	4072-2707	3.34	53.5 µM	8.91E-4		30	4.13E-4
19	SGTC_2576	guaiol	3.29	23.1 µM	0.00107		56	5.06E-4
20	SGTC_330	1488-0319	3.21	80.1 µM	0.00136	RPP1 & pyrimidine depletion	35	6.63E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.248	2.89E-48	YPR116W	RRG8	hom	Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.210	1.12E-34	YLR139C	SLS1	hom	Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
0.199	2.12E-31	YER077C_p	YER077C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.180	8.91E-26	YNL284C	MRPL10	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.179	1.50E-25	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.167	1.91E-22	YMR282C	AEP2	hom	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.164	1.16E-21	YDR405W	MRP20	hom	Mitochondrial ribosomal protein of the large subunit
0.163	2.90E-21	YHR011W	DIA4	hom	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
0.159	2.06E-20	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.159	1.86E-20	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.158	2.87E-20	YDL044C	MTF2	hom	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
0.156	1.21E-19	YER122C	GLO3	hom	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.155	1.66E-19	YGR222W	PET54	hom	Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
0.155	2.23E-19	YLL027W	ISA1	hom	Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.155	2.19E-19	YBL038W	MRPL16	hom	Mitochondrial ribosomal protein of the large subunit