YOR200W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR200W / YOR200W

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.40|P-value:1.61E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.23|P-value:2.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.06|P-value:4.62E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.52|P-value:1.11E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.98|P-value:2.38E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:4.77|P-value:4.87E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:4.93|P-value:2.84E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.35|P-value:6.18E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.91|P-value:7.00E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.60|P-value:7.37E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.40|P-value:8.42E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:16.90|P-value:8.11E-44 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.20|P-value:1.66E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:8.11|P-value:1.57E-11 ID:SGTC_365|Compound:0121-0052|FD-Score:4.09|P-value:4.26E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.03|P-value:4.97E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.24|P-value:2.36E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.27|P-value:8.20E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:-3.87|P-value:6.96E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.28|P-value:6.68E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.34|P-value:1.96E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.68|P-value:6.56E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.40|P-value:1.62E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.79|P-value:9.86E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.49|P-value:3.63E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.06|P-value:1.78E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.70|P-value:6.18E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.71|P-value:5.13E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.85|P-value:8.41E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.22|P-value:2.50E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.76|P-value:9.46E-4 ID:SGTC_1761|Compound:st044296|FD-Score:4.90|P-value:3.15E-5 ID:SGTC_1762|Compound:st045503|FD-Score:4.57|P-value:9.41E-5 ID:SGTC_2118|Compound:5526350|FD-Score:-3.80|P-value:8.58E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.02|P-value:5.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.64|P-value:7.39E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.82|P-value:9.07E-4 ID:SGTC_2276|Compound:7947513|FD-Score:6.03|P-value:4.03E-7 ID:SGTC_2350|Compound:9023895|FD-Score:-4.55|P-value:8.84E-5 ID:SGTC_2353|Compound:9059630|FD-Score:4.50|P-value:1.19E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.27|P-value:2.42E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.96|P-value:5.36E-7 ID:SGTC_10|Compound:0279-0212|FD-Score:4.40|P-value:1.61E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.23|P-value:2.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.06|P-value:4.62E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.52|P-value:1.11E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.98|P-value:2.38E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:4.77|P-value:4.87E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:4.93|P-value:2.84E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.35|P-value:6.18E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.91|P-value:7.00E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.60|P-value:7.37E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.40|P-value:8.42E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:16.90|P-value:8.11E-44 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.20|P-value:1.66E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:8.11|P-value:1.57E-11 ID:SGTC_365|Compound:0121-0052|FD-Score:4.09|P-value:4.26E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.03|P-value:4.97E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.24|P-value:2.36E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.27|P-value:8.20E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:-3.87|P-value:6.96E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.28|P-value:6.68E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.34|P-value:1.96E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.68|P-value:6.56E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.40|P-value:1.62E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.79|P-value:9.86E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.49|P-value:3.63E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.06|P-value:1.78E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.70|P-value:6.18E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.71|P-value:5.13E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.85|P-value:8.41E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.22|P-value:2.50E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.76|P-value:9.46E-4 ID:SGTC_1761|Compound:st044296|FD-Score:4.90|P-value:3.15E-5 ID:SGTC_1762|Compound:st045503|FD-Score:4.57|P-value:9.41E-5 ID:SGTC_2118|Compound:5526350|FD-Score:-3.80|P-value:8.58E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.02|P-value:5.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.64|P-value:7.39E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.82|P-value:9.07E-4 ID:SGTC_2276|Compound:7947513|FD-Score:6.03|P-value:4.03E-7 ID:SGTC_2350|Compound:9023895|FD-Score:-4.55|P-value:8.84E-5 ID:SGTC_2353|Compound:9059630|FD-Score:4.50|P-value:1.19E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.27|P-value:2.42E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.96|P-value:5.36E-7

Top fitness defect scores for YOR200W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.90 5.3 µM 8.11E-44 78 3.44E-64
2 SGTC_275 trichlorophene 11.20 5.7 µM 1.66E-20 mitochondrial stress 31 1.29E-29
3 SGTC_310 1273-0058 8.11 1.1 µM 1.57E-11 mitochondrial stress 86 2.51E-16
4 SGTC_173 1273-0061 6.40 2.7 µM 8.42E-8 mitochondrial stress 100 8.01E-11
5 SGTC_2276 7947513 6.03 42.1 µM 4.03E-7 5 8.06E-10
6 SGTC_2762 leflunomide 5.96 42.1 µM 5.36E-7 3 1.23E-9
7 SGTC_1188 1403-0014 5.49 4.6 µM 3.63E-6 mitochondrial stress 20 2.05E-8
8 SGTC_118 0083-0097 5.35 135.3 µM 6.18E-6 translation 44 4.46E-8
9 SGTC_691 1548-0686 5.27 185.0 µM 8.20E-6 9 6.76E-8
10 SGTC_1274 0865-0114 5.06 173.0 µM 1.78E-5 8 2.11E-7
11 SGTC_87 0100-0052 4.98 35.5 µM 2.38E-5 55 3.23E-7
12 SGTC_98 0074-0023 4.93 107.7 µM 2.84E-5 Golgi 21 4.19E-7
13 SGTC_1761 st044296 4.90 37.0 µM 3.15E-5 6 4.88E-7
14 SGTC_91 0417-1751 4.77 58.4 µM 4.87E-5 Golgi 29 9.24E-7
15 SGTC_1539 benzyladenosine 4.70 56.0 µM 6.18E-5 4 1.31E-6
16 SGTC_1065 prochlorperazine maleate 4.68 2.5 µM 6.56E-5 4 1.43E-6
17 SGTC_2250 alverine citrate 4.64 130.0 µM 7.39E-5 112 1.70E-6
18 SGTC_1762 st045503 4.57 25.5 µM 9.41E-5 16 2.42E-6
19 SGTC_70 0141-0289 4.52 43.3 µM 1.11E-4 mitochondrial stress 134 3.09E-6
20 SGTC_2353 9059630 4.50 146.7 µM 1.19E-4 15 3.41E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.512 2.19E-223 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.479 2.09E-192 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.467 2.04E-181 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.467 8.06E-181 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.458 1.44E-173 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.456 7.86E-172 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.448 1.39E-165 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.434 2.47E-154 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.433 4.30E-153 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.426 1.13E-147 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.425 1.31E-147 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.424 1.76E-146 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.411 2.85E-137 YBL080C PET112 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
0.405 1.08E-132 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.404 5.40E-132 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels