YOR203W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR203W / YOR203W

Click on Significant Values for Screen Details ID:SGTC_200|Compound:k038-0079|FD-Score:3.10|P-value:9.00E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.61|P-value:1.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.32|P-value:4.17E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.33|P-value:3.92E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.29|P-value:7.90E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.10|P-value:2.08E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.52|P-value:1.98E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.75|P-value:7.88E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:6.09|P-value:4.73E-10 ID:SGTC_647|Compound:0140-0236|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.86|P-value:5.75E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.72|P-value:8.94E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.21|P-value:6.79E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.22|P-value:5.96E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.21|P-value:6.21E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.25|P-value:5.91E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.70|P-value:1.11E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.57|P-value:1.64E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.38|P-value:5.29E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-3.36|P-value:3.93E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.25|P-value:5.91E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.82|P-value:5.96E-5 ID:SGTC_1753|Compound:st043925|FD-Score:4.02|P-value:2.60E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.03|P-value:2.46E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.16|P-value:8.05E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.12|P-value:1.95E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.74|P-value:8.23E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-4.87|P-value:5.57E-7 ID:SGTC_2055|Compound:5235184|FD-Score:4.06|P-value:2.22E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.27|P-value:4.92E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.64|P-value:1.24E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.40|P-value:4.77E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.03|P-value:2.50E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.02|P-value:2.58E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-4.20|P-value:1.38E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.34|P-value:4.21E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:-3.33|P-value:4.37E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.55|P-value:1.98E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.16|P-value:1.04E-7 ID:SGTC_2812|Compound:7970281|FD-Score:4.01|P-value:2.77E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-3.20|P-value:7.04E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.70|P-value:1.09E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.57|P-value:1.59E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-4.25|P-value:1.07E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.66|P-value:1.30E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.17|P-value:7.90E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.10|P-value:9.00E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.61|P-value:1.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.32|P-value:4.17E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.33|P-value:3.92E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.29|P-value:7.90E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.10|P-value:2.08E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.52|P-value:1.98E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.75|P-value:7.88E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:6.09|P-value:4.73E-10 ID:SGTC_647|Compound:0140-0236|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.86|P-value:5.75E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.72|P-value:8.94E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.21|P-value:6.79E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.22|P-value:5.96E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.21|P-value:6.21E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.25|P-value:5.91E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.70|P-value:1.11E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.57|P-value:1.64E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.38|P-value:5.29E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-3.36|P-value:3.93E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.25|P-value:5.91E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.82|P-value:5.96E-5 ID:SGTC_1753|Compound:st043925|FD-Score:4.02|P-value:2.60E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.03|P-value:2.46E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.33|P-value:3.91E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.16|P-value:8.05E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.12|P-value:1.95E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.74|P-value:8.23E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-4.87|P-value:5.57E-7 ID:SGTC_2055|Compound:5235184|FD-Score:4.06|P-value:2.22E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.27|P-value:4.92E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.64|P-value:1.24E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.40|P-value:4.77E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.03|P-value:2.50E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.02|P-value:2.58E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-4.20|P-value:1.38E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.34|P-value:4.21E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:-3.33|P-value:4.37E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.55|P-value:1.98E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.16|P-value:1.04E-7 ID:SGTC_2812|Compound:7970281|FD-Score:4.01|P-value:2.77E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-3.20|P-value:7.04E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.70|P-value:1.09E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.57|P-value:1.59E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-4.25|P-value:1.07E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.66|P-value:1.30E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.17|P-value:7.90E-4

Top fitness defect scores for YOR203W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_514 4466-0038 6.09 2.6 nM 4.73E-10 cell wall 16 5.79E-10 0.07
2 SGTC_2778 tioconazole 5.16 65.1 nM 1.04E-7 ergosterol depletion effects on membrane 17 1.22E-7 0.11
3 SGTC_2338 7999974 4.40 200.0 µM 4.77E-6 4 5.42E-6 0.09
4 SGTC_1362 1611-0397 4.38 101.0 µM 5.29E-6 2 6.01E-6 0.57
5 SGTC_313 3474-0040 4.29 5.0 µM 7.90E-6 NEO1-PIK1 4 8.94E-6 0.06
6 SGTC_2055 5235184 4.06 200.0 µM 2.22E-5 ERG2 5 2.49E-5 0.57
7 SGTC_1829 berberine 4.03 14.4 µM 2.46E-5 60S ribosome export 13 2.75E-5 0.36
8 SGTC_2411 st077133 4.03 39.9 µM 2.50E-5 RNA pol III & RNase P/MRP 18 2.80E-5 0.10
9 SGTC_2415 st077333 4.02 57.7 µM 2.58E-5 15 2.88E-5 0.02
10 SGTC_1753 st043925 4.02 64.0 µM 2.60E-5 2 2.91E-5 0.01
11 SGTC_2812 7970281 4.01 58.4 µM 2.77E-5 8 3.10E-5 0.12
12 SGTC_1743 st037606 3.82 46.4 µM 5.96E-5 7 6.62E-5 0.00
13 SGTC_394 menadione 3.75 8.3 µM 7.88E-5 superoxide 7 8.73E-5 0.02
14 SGTC_2012 4023501 3.74 200.0 µM 8.23E-5 14 9.12E-5 0.09
15 SGTC_674 0498-0004 3.72 451.0 µM 8.94E-5 heme requiring 26 9.90E-5 0.06
16 SGTC_346 4513-0042 3.66 7.2 µM 1.16E-4 azole & statin 8 1.28E-4 0.05
17 SGTC_2058 5236698 3.64 133.0 µM 1.24E-4 6 1.37E-4 0.05
18 SGTC_201 4262-0159 3.61 12.8 µM 1.37E-4 ergosterol depletion effects on membrane 13 1.51E-4 0.07
19 SGTC_1348 1493-0373 3.61 93.8 µM 1.41E-4 7 1.55E-4 0.01
20 SGTC_647 0140-0236 3.58 81.0 µM 1.58E-4 7 1.74E-4 0.43

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.68E-14 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.125 3.13E-13 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.123 1.00E-12 YDL084W SUB2 het Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.121 1.65E-12 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.118 8.19E-12 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.114 3.91E-11 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.111 1.05E-10 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.102 3.82E-9 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.101 5.38E-9 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.095 3.54E-8 YNL053W MSG5 hom Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p
0.094 5.11E-8 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.092 9.68E-8 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.091 1.12E-7 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.091 1.40E-7 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.090 2.01E-7 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress